Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Linsey Porter"'
Autor:
Marta Vilà-González, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L. Hart, Frank McCaughan, Alessandra Granata, David N. Sheppard, R. Andres Floto, Emma L. Rawlins, Pietro Cicuta, Ludovic Vallier
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Pulmonary ionocytes have been identified in the airway epithelium as a small population of ion transporting cells expressing high levels of CFTR (cystic fibrosis transmembrane conductance regulator), the gene mutated in cystic fib
Externí odkaz:
https://doaj.org/article/6ef9e41560be48c89f72cdcceb53767c
Autor:
Ricardo C. Ferreira, Daniel B. Rainbow, Arcadio Rubio García, Marcin L. Pekalski, Linsey Porter, João J. Oliveira, Frank Waldron-Lynch, Linda S. Wicker, John A. Todd
Publikováno v:
Data in Brief, Vol 12, Iss C, Pp 676-691 (2017)
We provide in this paper a detailed characterization of the human peripheral CD4+ CD127lowCD25+ regulatory T cell (Treg) compartment, with a particular emphasis in defining the population expressing higher levels of the IL-6 receptor (IL-6R). We prov
Externí odkaz:
https://doaj.org/article/118550356a274a4582df91b80dc090ad
Autor:
Linsey Porter, Nicole Toepfner, Kathleen R. Bashant, Jochen Guck, Margaret Ashcroft, Neda Farahi, Edwin R. Chilvers
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Immune cells face constant changes in their microenvironment, which requires rapid metabolic adaptation. In contrast to neutrophils, which are known to rely near exclusively on glycolysis, the metabolic profile of human eosinophils has not been chara
Externí odkaz:
https://doaj.org/article/13a146fdd4774462913bc490d0cf037e
Autor:
John A Todd, Marina Evangelou, Antony J Cutler, Marcin L Pekalski, Neil M Walker, Helen E Stevens, Linsey Porter, Deborah J Smyth, Daniel B Rainbow, Ricardo C Ferreira, Laura Esposito, Kara M D Hunter, Kevin Loudon, Kathryn Irons, Jennie H Yang, Charles J M Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I Tree, Mark Evans, Adrian P Mander, Simon Bond, Linda S Wicker, Frank Waldron-Lynch
Publikováno v:
PLoS Medicine, Vol 13, Iss 10, p e1002139 (2016)
BackgroundInterleukin-2 (IL-2) has an essential role in the expansion and function of CD4+ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and regulate autoreactive CD4+ effector T cells (Tef
Externí odkaz:
https://doaj.org/article/ce713b3d60664d62831f35693cfd7b82
Autor:
Linsey Porter, Wenrui Guo, Thomas Crozier, Edward Greenwood, Brian Morris Ortmann, Daniel Kottmann, James Nathan, Ravindra Mahadeva, Paul Lehner, Frank McCaughan
Publikováno v:
SSRN Electronic Journal.
Autor:
Edward J. D. Greenwood, Brian Ortmann, Paul J. Lehner, James A. Nathan, Frank McCaughan, Daniel Kottmann, Ravindra Mahadeva, Wenrui Guo, Linsey Porter, Thomas W M Crozier
Cigarette smoking has multiple serious negative health consequences. However, the epidemiological relationship between cigarette smoking and SARS-CoV-2 infection is controversial; and the interaction between cigarette smoking, airway expression of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5f816399bcd216e9969ce18445f8342
https://doi.org/10.1101/2021.09.08.459428
https://doi.org/10.1101/2021.09.08.459428
Autor:
Paul J. Lehner, Akhilesh Jha, James A. Nathan, Thomas Wm Crozier, Guo W, Frank McCaughan, Edward J. D. Greenwood, Coates M, Linsey Porter, McKie M
BackgroundThere are limited effective prophylactic treatments for SARS-CoV-2 infection, and limited early treatment options. Viral cell entry requires spike protein binding to the ACE2 receptor and spike cleavage by TMPRSS2, a cell surface serine pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfb75a075fc84d42b6342b8417c70a6e
https://doi.org/10.1101/2021.04.23.440619
https://doi.org/10.1101/2021.04.23.440619
Autor:
Edwin R. Chilvers, John Deighton, Alison M. Condliffe, Linsey Porter, Neda Farahi, Stuart N. Farrow, Andrew S. Cowburn, Christine A Fiddler, Jatinder K. Juss
Publikováno v:
Clinical & Experimental Allergy. 47:770-784
Background Inflamed environments are typically hypercellular, rich in pro-inflammatory cytokines, and profoundly hypoxic. While the effects of hypoxia on neutrophil longevity and function have been widely studied, little is known about the consequenc
Autor:
Eleonora Seelig, Emma L Arbon, Marcin L. Pekalski, James Howlett, Linda S. Wicker, Adrian Mander, Neil Walker, Mark L. Evans, Linsey Porter, James Heywood, Simon Bond, Ravinder Atkar, Ed Rytina, John A. Todd, Katerina Anselmiova, Lucy Truman, Jane Kennet, Frank Waldron-Lynch
BACKGROUND. Type 1 diabetes (T1D) results from loss of immune regulation, leading to the development of autoimmunity to pancreatic β cells, involving autoreactive T effector cells (Teffs). Tregs, which prevent autoimmunity, require IL-2 for maintena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660273a0ea5d1eeb85c57d85161b7002
https://www.repository.cam.ac.uk/handle/1810/285685
https://www.repository.cam.ac.uk/handle/1810/285685
Autor:
Ravinder Atkar, Katerina Anselmiova, Mark L. Evans, Emma L Arbon, Simon Bond, Adrian Mander, Eleonora Seelig, Jane Kennet, Marcin L. Pekalski, John A. Todd, Lucy Truman, Linda S. Wicker, Linsey Porter, Neil Walker, Ed Rytina, James Heywood, Frank Waldron-Lynch, James Howlett
SummaryBackgroundType 1 diabetes (T1D) results from loss of immune regulation leading to the development of autoimmunity to pancreatic beta-cells, involving autoreactive T effector cells (Teffs). Regulatory T cells (Tregs), that prevent autoimmunity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a9ea698d9a75a0cad2c04e6ce56210