7-Aryl-7-deazapurine 3'-deoxyribonucleoside derivative as a novel lead for Chagas' disease therapy: in vitro and in vivo pharmacology.

Autor: Cardoso-Santos C; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC/FIOCRUZ), 21040-360 Rio de Janeiro, RJ, Brazil.; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Antwerp, Belgium., Ferreira de Almeida Fiuza L; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC/FIOCRUZ), 21040-360 Rio de Janeiro, RJ, Brazil., França da Silva C; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC/FIOCRUZ), 21040-360 Rio de Janeiro, RJ, Brazil., Mazzeti AL; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC/FIOCRUZ), 21040-360 Rio de Janeiro, RJ, Brazil., Donola Girão R; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC/FIOCRUZ), 21040-360 Rio de Janeiro, RJ, Brazil., Melo de Oliveira G; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC/FIOCRUZ), 21040-360 Rio de Janeiro, RJ, Brazil., da Gama Jaen Batista D; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC/FIOCRUZ), 21040-360 Rio de Janeiro, RJ, Brazil., Cruz Moreira O; Real Time PCR Platform RPT09A, Laboratory of Molecular Biology and Endemic Diseases, Oswaldo Cruz Institute (IOC/FIOCRUZ), Rio de Janeiro, RJ, Brazil., Lins da Silva Gomes N; Real Time PCR Platform RPT09A, Laboratory of Molecular Biology and Endemic Diseases, Oswaldo Cruz Institute (IOC/FIOCRUZ), Rio de Janeiro, RJ, Brazil., Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Antwerp, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, 2610 Wilrijk, Antwerp, Belgium., Hulpia F; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, 9000 Gent, Belgium., Calenbergh SV; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, 9000 Gent, Belgium., Correia Soeiro MN; Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC/FIOCRUZ), 21040-360 Rio de Janeiro, RJ, Brazil.

Publikováno v: JAC-antimicrobial resistance [JAC Antimicrob Resist] 2021 Nov 17; Vol. 3 (4), pp. dlab168. Date of Electronic Publication: 2021 Nov 17 (Print Publication: 2021).

Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches.

Autor: Fiuza, Ludmila F. de A.¹ (AUTHOR), Batista, Denise G. J.¹ (AUTHOR), Girão, Roberson D.¹ (AUTHOR), Hulpia, Fabian² (AUTHOR), Finamore-Araújo, Paula³ (AUTHOR), Aldfer, Mustafa M.⁴ (AUTHOR), Elmahallawy, Ehab Kotb^4,5 (AUTHOR), De Koning, Harry P.⁴ (AUTHOR), Moreira, Otacílio³ (AUTHOR), Van Calenbergh, Serge² (AUTHOR), Soeiro, Maria de Nazaré C.¹ (AUTHOR) soeiro@ioc.fiocruz.br

Publikováno v: Molecules. Nov2022, Vol. 27 Issue 22, p8087. 17p.