Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Linping Xu"'
Publikováno v:
Chinese Medical Journal, Vol 137, Iss 11, Pp 1285-1302 (2024)
Abstract. The advent of chimeric antigen receptor (CAR)-T cell immunotherapies has led to breakthroughs in the treatment of hematological malignancies. However, their success in treating solid tumors has been limited. CAR-natural killer (NK) cells ha
Externí odkaz:
https://doaj.org/article/abee27cb29594a5f9a025fa68686c444
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Inositol 1,4,5-Trisphosphate Receptor-Interacting Protein-Like 1 (ITPRIPL1), a single-pass type I membrane protein located in the membrane, functions as an inhibitory ligand of CD3ε. Recent studies have shown that its expression suppresses T cells a
Externí odkaz:
https://doaj.org/article/9ef9b9d3902447c5a1e31e85145f991d
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101150- (2024)
The advent of tyrosine kinase inhibitors (TKI) targeting BCR-ABL has drastically changed the treatment approach of chronic myeloid leukemia (CML), greatly prolonged the life of CML patients, and improved their prognosis. However, TKI resistance is st
Externí odkaz:
https://doaj.org/article/7cfec49cead04316911cebf15dc34f7c
Autor:
Wei Li, Binglei Zhang, Weijie Cao, Wenli Zhang, Tiandong Li, Lina Liu, LinPing Xu, Fengcai Gao, Yanmei Wang, Fang Wang, Haizhou Xing, Zhongxing Jiang, Jianxiang Shi, Zhilei Bian, Yongping Song
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-19 (2023)
Abstract Background BCMA CAR-T is highly effective for relapsed/refractory multiple myeloma(R/R-MM) and significantly improves the survival of patients. However, the short remission time and high relapse rate of MM patients treated with BCMA CAR-T re
Externí odkaz:
https://doaj.org/article/c65dba6263854701a81e1cfc1117a3dc
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-28 (2022)
Abstract In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most abundant immune cells, which act as a key regulator in tumorigenesis and progression. Increasing evidence have demonstrated that the TME alters the nature
Externí odkaz:
https://doaj.org/article/6fe9cdf45eb04d93ab4724c45e0eefb6
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background The phagocytosis checkpoints of CD47/SIRPα, PD1/PDL1, CD24/SIGLEC10, and MHC/LILRB1 have shown inhibited phagocytosis of macrophages in distinct tumors. However, phagocytosis checkpoints and their therapeutic significance remain
Externí odkaz:
https://doaj.org/article/4e35a7c262e049a0b507897023830fe4
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundIt has been shown that tumor-associated immune cells, particularly macrophages, play a fundamental role in the development and treatment response of intrahepatic cholangiocarcinoma (ICC). However, little is known about macrophages at the si
Externí odkaz:
https://doaj.org/article/3c3f872d4e304c88b1a69b120880018b
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-13 (2021)
Abstract Long noncoding RNAs (lncRNAs) play crucial roles in regulating a variety of biological processes in lung adenocarcinoma (LUAD). In our study, we mainly explored the functional roles of a novel lncRNA long intergenic non-protein coding RNA 14
Externí odkaz:
https://doaj.org/article/6c104579df394324ad6aeaf7e00e4735
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-13 (2021)
Abstract Programmed death-ligand 1 (PD-L1) on cancer cells engages with programmed cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple cancer types, the PD-1/PD-L1 axis is the major speed-limiting step of the anti-
Externí odkaz:
https://doaj.org/article/70a362369cc8470f9056ad1a9cf7cdcb
Autor:
Qiaoyun Guo, Linping Xu, Rui Peng, Yan Ma, Yanli Wang, Feifei Chong, Mengmeng Song, Liping Dai, Chunhua Song
Publikováno v:
Cancer Medicine, Vol 9, Iss 6, Pp 2252-2268 (2020)
Abstract Background The aim was to evaluate the association between the LINC00520 genetic polymorphisms and breast cancer (BC) susceptibility. Methods Nine single‐nucleotide polymorphisms (SNPs) on LINC00520 genotyping were performed in 504 BC pati
Externí odkaz:
https://doaj.org/article/50aef6d82bf4451cb5ab71f2d28be56b