Zobrazeno 1 - 10
of 375
pro vyhledávání: '"Linopirdine"'
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 429 (2022)
Pulmonary hypertension is treated with drugs that stimulate cGMP or cAMP signalling. Both nucleotides can activate Kv7 channels, leading to smooth muscle hyperpolarisation, reduced Ca2+ influx and relaxation. Kv7 activation by cGMP contributes to the
Externí odkaz:
https://doaj.org/article/0102e1aa4e37426d983729882b147f7e
Autor:
Matthias Majetschak, Favin S. Babu
Publikováno v:
Physiol Res
Previously, we demonstrated that supplementation of resuscitation fluids with the Kv7 voltage-activated potassium channel inhibitor linopirdine reduces fluid resuscitation requirements and stabilizes hemodynamics in various rat models of hemorrhagic
Autor:
Morten B. Thomsen, Thomas A. Jepps, Geoffrey W. Abbott, Rían W. Manville, Jennifer van der Horst, Katie Hayes
Publikováno v:
Van Der Horst, J, Manville, R W, Hayes, K, Thomsen, M B, Abbott, G W & Jepps, T A 2020, ' Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 40, no. 5, pp. 1207-1219 . https://doi.org/10.1161/ATVBAHA.120.313997
Arterioscler Thromb Vasc Biol
Arterioscler Thromb Vasc Biol
Objective: Intravenous acetaminophen/paracetamol (APAP) is well documented to cause hypotension. Since the patients receiving intravenous APAP are usually critically ill, any severe hemodynamic changes, as with those associated with APAP, can be life
Autor:
Il-Whan Choi, Hongzoo Park, Won-Kyo Jung, Hee Seok Jung, Geehyun Song, Won Sun Park, Jin Ryeol An, Mi Seon Seo, Minji Kang, Ryeon Heo
Publikováno v:
Pharmacological Reports. 73:1724-1733
Background Olanzapine, an FDA-approved atypical antipsychotic, is widely used to treat schizophrenia and bipolar disorder. In this study, the inhibitory effect of olanzapine on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth mus
Publikováno v:
Neurobiology of Disease, Vol 56, Iss , Pp 14-24 (2013)
In models of temporal lobe epilepsy, in-vitro exposure of the entorhinal cortex (EC) to low concentrations of acetylcholine (ACh) induces muscarinic-dependent seizure-like events. Potassium channels from the KCNQ/Kv7 family, which close upon activati
Externí odkaz:
https://doaj.org/article/e1e82fc79d494a81988eab630401ba8c
Inhibition of voltage‐dependent K + channels by iloperidone in coronary arterial smooth muscle cells
Autor:
Hee Seok Jung, Mi Seon Seo, Jin Ryeol An, Won Sun Park, Eun-Taek Han, Se-Ran Yang, Young Min Bae, Minji Kang, Ryeon Heo
Publikováno v:
Journal of Applied Toxicology. 40:1297-1305
Iloperidone, a second-generation atypical antipsychotic drug, is widely used in the treatment of schizophrenia. However, the side-effects of iloperidone on vascular K+ channels remain to be determined. Therefore, we explored the effect of iloperidone
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Publikováno v:
Journal of Exercise Nutrition & Biochemistry
[Purpose] Previous studies have indicated that Kv7 channels have an important role in the regulation of blood vessel reactivity, including in the coronary, renal, and cerebral arteries. The present studies examined whether Kv7 channels regulated vasc
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in Physiology
The pre-Bötzinger complex (preBötC) of the ventral medulla generates the mammalian inspiratory breathing rhythm. When isolated in explants and deprived of synaptic inhibition, the preBötC continues to generate inspiratory-related rhythm. Mechanism
Autor:
Wei Ting Chang, Sheng Nan Wu
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 388, p 388 (2021)
Volume 14
Issue 5
Pharmaceuticals, Vol 14, Iss 388, p 388 (2021)
Volume 14
Issue 5
QO-40 (5-(chloromethyl)-3-(naphthalene-1-yl)-2-(trifluoromethyl) pyrazolo[1,5-a]pyrimidin-7(4H)-one) is a novel and selective activator of KCNQ2/KCNQ3 K+ channels. However, it remains largely unknown whether this compound can modify any other type of