Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lino C Gonzalez"'
Autor:
Jillian L Astarita, Shilpa Keerthivasan, Bushra Husain, Yasin Şenbabaoğlu, Erik Verschueren, Sarah Gierke, Victoria C Pham, Sean M Peterson, Cecile Chalouni, Andrew A Pierce, Jennie R Lill, Lino C Gonzalez, Nadia Martinez-Martin, Shannon J Turley
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0260800 (2021)
The cancer-associated fibroblast (CAF) marker podoplanin (PDPN) is generally correlated with poor clinical outcomes in cancer patients and thus represents a promising therapeutic target. Despite its biomedical relevance, basic aspects of PDPN biology
Externí odkaz:
https://doaj.org/article/8316f5321a80472a90ee5255614182c9
Autor:
Patrick C G Haddick, Irene Tom, Elizabeth Luis, Gabriel Quiñones, Bernd J Wranik, Sree R Ramani, Jean-Philippe Stephan, Marc Tessier-Lavigne, Lino C Gonzalez
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84823 (2014)
The growth and guidance of many axons in the developing nervous system require Netrin-mediated activation of Deleted in Colorectal Cancer (DCC) and other still unknown signaling cues. Commissural axon guidance defects are more severe in DCC mutant mi
Externí odkaz:
https://doaj.org/article/82008ca3e8ff4fe3a9ce17ecd4ee7c6a
Autor:
Steven E Kauder, Lydia Santell, Elaine Mai, Lilyan Y Wright, Elizabeth Luis, Elsa N N'Diaye, Jeff Lutman, Navneet Ratti, Susan M Sa, Henry R Maun, Eric Stefanich, Lino C Gonzalez, Robert R Graham, Lauri Diehl, William A Faubion, Mary E Keir, Judy Young, Amitabha Chaudhuri, Robert A Lazarus, Jackson G Egen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83958 (2013)
Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON). A non-synonymous coding variant in MSP (689C) has been associated with genetic susceptibility t
Externí odkaz:
https://doaj.org/article/6b29382e11a343b58a0d4a762432fc8a
Autor:
Isabelle Lehoux, Shannon J. Turley, Jane L. Grogan, Pamela Chan, Athena W. Wong, Bushra Husain, Jennie R. Lill, Sree R. Ramani, Tia A. Arena, Eugene Chiang, Yvonne Franke, Lino C. Gonzalez, Sairupa Paduchuri, Blair Wilson, Ashka Patel, Nadia Martinez-Martin
Publikováno v:
Mol Cell Proteomics
Receptors expressed on the plasma membrane and their interacting partners critically regulate cellular communication during homeostasis and disease, and as such represent main therapeutic targets. Despite its importance for drug development, receptor
Autor:
Erik Verschueren, Yasin Senbabaoglu, Pamela Chan, Steve Lianoglou, Sanjeev Mariathasan, Tia A. Arena, Yvonne Franke, Isabelle Lehoux, Athena W. Wong, Lino C. Gonzalez, Bushra Husain, Sairupa Paduchuri, Yi Sun, Shannon J. Turley, Nadia Martinez-Martin, Corey E. Bakalarski, Kobe C. Yuen, Blair Wilson, Jennie R. Lill
Publikováno v:
Cell. 182(2)
Cell surface receptors and their interactions play a central role in physiological and pathological signaling. Despite its clinical relevance, the immunoglobulin superfamily (IgSF) remains uncharacterized and underrepresented in databases. Here, we p
Autor:
Chin Chun Ooi, Lino C. Gonzalez, Jung Rok Lee, Daniel J.B. Bechstein, Shan X. Wang, Richard S. Gaster, Ashka Patel, Elaine Ng
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature Communications
Nature Communications
Substantial efforts have been made to understand the interactions between immune checkpoint receptors and their ligands targeted in immunotherapies against cancer. To carefully characterize the complete network of interactions involved and the bindin
Publikováno v:
Neuron. 91:328-340
Summary Genetic variants of TREM2, a protein expressed selectively by microglia in the brain, are associated with Alzheimer's disease (AD). Starting from an unbiased protein microarray screen, we identified a set of lipoprotein particles (including L
Autor:
Alexander Jaworski, Marc Tessier-Lavigne, Lino C. Gonzalez, Holly K. Gildea, Alexander W. Koch, Raymond K. Tong, Irene Tom
Publikováno v:
Science. 350:961-965
Axon pathfinding is orchestrated by numerous guidance cues, including Slits and their Robo receptors, but it remains unclear how information from multiple cues is integrated or filtered. Robo3, a Robo family member, allows commissural axons to reach
Autor:
Bernd Wranik, Hilary Clark, Jason A. Hackney, Philip E. Hass, Kentaro Takeda, Maciej Paluch, Sree R. Ramani, Michelle Chan, Johnny Wu, Lino C. Gonzalez, Nadia Martinez-Martin, Irene Tom
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-3 (2017)
Nature Communications
Nature Communications
Viruses encode secreted and cell-surface expressed proteins essential to modulate host immune defenses and establish productive infections. However, to date there has been no systematic study of the extracellular interactome of any human virus. Here
Autor:
Sree R. Ramani, Homer Pantua, Arthur Wuster, Sharookh B. Kapadia, Yonglian Sun, Ali A. Zarrin, Timothy W. Behrens, Manav Kapoor, Lino C. Gonzalez, Jian Payandeh, Robert R. Graham, Tushar Bhangale, Nisha Rathore, David V. Hansen, Alison Goate
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 11, p e1007427 (2018)
PLoS Genetics, Vol 14, Iss 11, p e1007427 (2018)
Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA) is a cell surface inhibitory receptor that recognizes specific O-glycosylated proteins and is expressed on various innate immune cell types including microglia. We show here that a common misse