Výsledky vyhledávání - "Linnet Akinyi"

Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats

Autor: Monika W. Oli, Kevin K.W. Wang, Ronald L. Hayes, Linnet Akinyi, Wenrong Zheng, Frank C. Tortella, Jitendra R. Dave, Uwe Müller, Xi-Chun Lu, Danica Scharf, Firas Kobeissy, Linda Papa, Ming Cheng Liu, Jixiang Mo, Stephen F. Larner

Publikováno v: European Journal of Neuroscience. 31:722-732

Ubiquitin C-terminal hydrolase-L1 (UCH-L1), also called neuronal-specific protein gene product 9.5, is a highly abundant protein in the neuronal cell body and has been identified as a possible biomarker on the basis of a recent proteomic study. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120de0eff3c16fc8c69736ff420b9d30
https://doi.org/10.1111/j.1460-9568.2010.07097.x

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Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury*

Autor: Monika W. Oli, Linnet Akinyi, Shelley C. Heaton, Ming Cheng Liu, Joseph J. Tepas, Claudia S. Robertson, Linda Papa, Joe Layon, Andrea Gabrielli, Wenrong Zheng, Jose A. Pineda, H. Julia Hannay, Steven A. Robicsek, Ronald L. Hayes, Kevin K.W. Wang, Gillian Robinson, Gretchen M. Brophy, Jason A. Demery

Publikováno v: Critical Care Medicine. 38:138-144

Ubiquitin C-terminal hydrolase (UCH-L1), also called neuronal-specific protein gene product (PGP 9.3), is highly abundant in neurons. To assess the reliability of UCH-L1 as a potential biomarker for traumatic brain injury (TBI) this study compared ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac01d00d556235bd7d7d0464201ac054
https://doi.org/10.1097/ccm.0b013e3181b788ab

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Biochemical, Structural, and Biomarker Evidence for Calpain-Mediated Cytoskeletal Change After Diffuse Brain Injury Uncomplicated by Contusion

Autor: John T. Povlishock, Monika W. Oli, Linnet Akinyi, Ronald L. Hayes, Kevin K.W. Wang, Melissa J. McGinn, Ming Cheng Liu, Brian J. Kelley

Publikováno v: Journal of Neuropathology & Experimental Neurology. 68:241-249

Calpain-mediated degradation of the cytoskeletal protein alpha-II-spectrin has been implicated in the pathobiology of experimental and human traumatic brain injury (TBI). Spectrin proteolysis after diffuse/widespread TBI uncomplicated by either subtl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c765ddacff84745ccb39a75909f452f7
https://doi.org/10.1097/nen.0b013e3181996bfe

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Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention

Autor: Linnet Akinyi, Kara Schmid, Ronald L. Hayes, Philip Giordano, Jason A. Demery, Ming Cheng Liu, Salvatore Silvestri, Kevin K.W. Wang, Claudia S. Robertson, Lawrence M. Lewis, Jay L. Falk, Gretchen M. Brophy, Frank C. Tortella, Linda Papa, Stefania Mondello, Jixiang Mo

Publikováno v: The journal of trauma and acute care surgery. 72(5)

This study compared early serum levels of ubiquitin C-terminal hydrolase (UCH-L1) from patients with mild and moderate traumatic brain injury (TBI) with uninjured and injured controls and examined their association with traumatic intracranial lesions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef601aad2290ebd23385189f267f871
https://pubmed.ncbi.nlm.nih.gov/22673263

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Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention

Autor: Linnet Akinyi, Kara Schmid, Ming Cheng Liu, Frank C. Tortella, Jay L. Falk, Neha K. Dixit, Ronald L. Hayes, Philip Giordano, Zhiqun Zhang, Jason A. Demery, Salvatore Silvestri, Claudia S. Robertson, Stefania Mondello, Gretchen M. Brophy, Ian Ferguson, Jixiang Mo, Kevin K.W. Wang, Lawrence M. Lewis, Linda Papa

Publikováno v: Annals of emergency medicine. 59(6)

Study objective This study examines whether serum levels of glial fibrillary acidic protein breakdown products (GFAP-BDP) are elevated in patients with mild and moderate traumatic brain injury compared with controls and whether they are associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9e193c9bc3a255f59154615e8674ab
https://pubmed.ncbi.nlm.nih.gov/22071014

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αII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients

Autor: Andrea Gabrielli, Uwe Müller, Steven A. Robicsek, Claudia S. Robertson, Gretchen M. Brophy, Joseph J. Tepas, Andras Buki, Stefania Mondello, Linda Papa, Linnet Akinyi, Kevin K.W. Wang, Dancia Scharf, Ronald L. Hayes, Mo Jixiang

Publikováno v: Journal of neurotrauma. 27(7)

In this study we assessed the clinical utility of quantitative assessments of alphaII-spectrin breakdown products (SBDP145 produced by calpain, and SBDP120 produced by caspase-3) in cerebrospinal fluid (CSF) as markers of brain damage and outcome aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eabab916be5340fb6cee00e6a88c98f
https://pubmed.ncbi.nlm.nih.gov/20408766

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αII-Spectrin Breakdown Products (SBDPs): Diagnosis and Outcome in Severe Traumatic Brain Injury Patients.

Autor: Stefania Mondello, Steven A. Robicsek, Andrea Gabrielli, Gretchen M. Brophy, Linda Papa, Joseph Tepas, Claudia Robertson, Andras Buki, Dancia Scharf, Mo Jixiang, Linnet Akinyi, Uwe Muller, Kevin K.W. Wang, Ronald L. Hayes

Publikováno v: Journal of Neurotrauma; Jul2010, Vol. 27 Issue 7, p1203-1213, 11p

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