Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Linnea Sandin"'
Publikováno v:
Biology Open, Vol 5, Iss 8, Pp 1030-1039 (2016)
The aggregation of the amyloid-β (Aβ) peptide into fibrillar deposits has long been considered the key neuropathological hallmark of Alzheimer's disease (AD). Aβ peptides are generated from proteolytic processing of the transmembrane Aβ precursor
Externí odkaz:
https://doaj.org/article/6e6d0c39db7c48f882a83f55af029754
Autor:
Linda Helmfors, Andrea Boman, Livia Civitelli, Sangeeta Nath, Linnea Sandin, Camilla Janefjord, Heather McCann, Henrik Zetterberg, Kaj Blennow, Glenda Halliday, Ann-Christin Brorsson, Katarina Kågedal
Publikováno v:
Neurobiology of Disease, Vol 83, Iss , Pp 122-133 (2015)
The hallmarks of Alzheimer disease are amyloid-β plaques and neurofibrillary tangles accompanied by signs of neuroinflammation. Lysozyme is a major player in the innate immune system and has recently been shown to prevent the aggregation of amyloid-
Externí odkaz:
https://doaj.org/article/3a95a0d4fd9045cd865fd14e511c17df
Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.
Autor:
Hanna Appelqvist, Linnea Sandin, Karin Björnström, Paul Saftig, Brett Garner, Karin Ollinger, Katarina Kågedal
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50262 (2012)
Alterations in lipid homeostasis are implicated in several neurodegenerative diseases, although the mechanisms responsible are poorly understood. We evaluated the impact of cholesterol accumulation, induced by U18666A, quinacrine or mutations in the
Externí odkaz:
https://doaj.org/article/b1b5bf883b464126b654b8227ca05d6b
Publikováno v:
Biochemistry. 60(37)
The prevailing opinion is that prefibrillar beta-amyloid (A beta) species, rather than end-stage amyloid fibrils, cause neuronal dysfunction in Alzheimers disease, although the mechanisms behind A beta neurotoxicity remain to be elucidated. Luminesce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe202a44a212469d0776c0a2f708a06
https://pubmed.ncbi.nlm.nih.gov/34469142
https://pubmed.ncbi.nlm.nih.gov/34469142
Autor:
Hongyun Li, Katarina Kågedal, Kaj Blennow, Linnea Sandin, Ann-Christin Brorsson, Sangeeta Nath, Claudia S. Kielkopf, Henrik Zetterberg, Brett Garner, Camilla Janefjord, Linda Helmfors, Liza Bergkvist, Camilla Nilsberth
Publikováno v:
The Febs Journal
The FEBS Journal
The FEBS Journal
Genetic polymorphisms of immune genes that associate with higher risk to develop Alzheimer’s disease (AD) have led to an increased research interest on the involvement of the immune system in AD pathogenesis. A link between amyloid pathology and im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95e046c1feb2717b085ce9d1b94d0f3
http://europepmc.org/articles/PMC5132093
http://europepmc.org/articles/PMC5132093
Publikováno v:
Biology Open
Biology Open, Vol 5, Iss 8, Pp 1030-1039 (2016)
Biology Open, Vol 5, Iss 8, Pp 1030-1039 (2016)
The aggregation of the amyloid-β (Aβ) peptide into fibrillar deposits has long been considered the key neuropathological hallmark of Alzheimer's disease (AD). Aβ peptides are generated from proteolytic processing of the transmembrane Aβ precursor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c274e6fdcb0f73a9bbf7f4164fcdde6
http://europepmc.org/articles/PMC5004604
http://europepmc.org/articles/PMC5004604
Autor:
Heather McCann, Linnea Sandin, Henrik Zetterberg, Livia Civitelli, Camilla Janefjord, Kaj Blennow, Glenda M. Halliday, Sangeeta Nath, Katarina Kågedal, Ann-Christin Brorsson, Linda Helmfors, Andrea Boman
Publikováno v:
Neurobiology of Disease, Vol 83, Iss, Pp 122-133 (2015)
The hallmarks of Alzheimer disease are amyloid-β plaques and neurofibrillary tangles accompanied by signs of neuroinflammation. Lysozyme is a major player in the innate immune system and has recently been shown to prevent the aggregation of amyloid-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5cc21a0a2055c1cbfbcef93e2577c9
http://www.sciencedirect.com/science/article/pii/S0969996115300449
http://www.sciencedirect.com/science/article/pii/S0969996115300449
The influence of lysozyme and oligothiophenes on amyloid-β toxicity in models of Alzheimer’s disease
Autor:
Linnea Sandin
Alzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia worldwide. Apart from dominantly inherited mutations, age is the major risk factor and as life expectancy increases the prevalence for AD escalates dramat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22475d0371e744eb5f9c85814ddc0bba
https://doi.org/10.3384/diss.diva-131797
https://doi.org/10.3384/diss.diva-131797
Autor:
Erin Nelson, Sikander Iqbal Khattak, Livia Civitelli, Katarina Kågedal, Ann-Christin Brorsson, Linnea Sandin
Publikováno v:
The Journal of Biological Chemistry
Aggregation of the amyloid-(beta) peptide (A beta) in the brain leads to the formation of extracellular amyloid plaques, which is one of the pathological hallmarks of Alzheimer disease (AD). It is a general hypothesis that soluble prefibrillar assemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4173abb2da19e2a310914e6f98af3a
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128747
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128747
Autor:
Heather McCann, Andrea Armstrong, Sangeeta Nath, Katarina Kågedal, Henrik Zetterberg, Glenda M. Halliday, Ann-Christine Brorsson, Linnea Sandin, Camilla Janefjord, Kaj Blennow
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f9bdeafa95a9c871113a2c227dc437c
https://doi.org/10.1016/j.jalz.2015.06.531
https://doi.org/10.1016/j.jalz.2015.06.531