Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Linnea Hases"'
Autor:
Christian Sommerauer, Carlos J Gallardo-Dodd, Christina Savva, Linnea Hases, Madeleine Birgersson, Rajitha Indukuri, Joanne X Shen, Pablo Carravilla, Keyi Geng, Jonas Nørskov Søndergaard, Clàudia Ferrer-Aumatell, Grégoire Mercier, Erdinc Sezgin, Marion Korach-André, Carl Petersson, Hannes Hagström, Volker M Lauschke, Amena Archer, Cecilia Williams, Claudia Kutter
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 4, Pp 374-402 (2024)
Abstract Sex-based differences in obesity-related hepatic malignancies suggest the protective roles of estrogen. Using a preclinical model, we dissected estrogen receptor (ER) isoform-driven molecular responses in high-fat diet (HFD)-induced liver di
Externí odkaz:
https://doaj.org/article/ee239cfd60044f218b6abfe27eac0000
Autor:
Linnea Hases, Lina Stepanauskaite, Madeleine Birgersson, Nele Brusselaers, Ina Schuppe-Koistinen, Amena Archer, Lars Engstrand, Cecilia Williams
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
A metagenomic analysis reveals that male and female mice exhibit sex-dependent responses to a high-fat diet (HFD), and that estrogenic ligands can attenuate certain aspects of HFDinduced dysbiosis.
Externí odkaz:
https://doaj.org/article/3a1403a1393f4fdbaf958e75f5ebbdec
Autor:
Fahmi Mesmar, Bingbing Dai, Ahmed Ibrahim, Linnea Hases, Mohammed Hakim Jafferali, Jithesh Jose Augustine, Sebastian DiLorenzo, Ya'an Kang, Yang Zhao, Jing Wang, Michael Kim, Chin‐Yo Lin, Anders Berkenstam, Jason Fleming, Cecilia Williams
Publikováno v:
Cancer Medicine, Vol 8, Iss 18, Pp 7705-7719 (2019)
Abstract Despite advances in cancer therapeutics, pancreatic cancer remains difficult to treat and often develops resistance to chemotherapies. We have evaluated a bioavailable genistein analogue, AXP107‐11 which has completed phase Ib clinical tri
Externí odkaz:
https://doaj.org/article/900afa4941d14028b0d39be55bc5e75d
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Inflammation is a primary component of both initiation and promotion of colorectal cancer (CRC). Cytokines secreted by macrophages, including tumor necrosis factor alpha (TNFα), activates the pro-survival transcription factor complex NFκB. The prec
Externí odkaz:
https://doaj.org/article/f6d5919d601c402bb804aa80e389c609
Autor:
Caroline Schagerholm, Stephanie Robertson, Barbro Holm, Karolina Lindberg, Emmanouil Sifakis, Linnea Hases, Cecilia Williams, Johan Hartman
Publikováno v:
Cancer Research. 82:P1-07
Background:. Up to 75% of breast cancer patients have tumors expressing the predictive biomarker estrogen receptor alpha (ER) and are consequently offered endocrine therapy. Approximately one third eventually relapse in their disease with the majorit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a94480dabd6725722dda9ec2cf198408
https://doi.org/10.1158/1538-7445.sabcs21-p1-07-07
https://doi.org/10.1158/1538-7445.sabcs21-p1-07-07
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10408
There are significant sex differences in colorectal cancer (CRC), including in incidence, onset, and molecular characteristics. Further, while inflammatory bowel disease (IBD) is a risk factor for CRC in both sexes, men with IBD have a 60% higher ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c22eb0a95d4c6bc2f6bf2e7aee8c3f
Autor:
Huan He, Cecilia Williams, Dandan Song, Lars Arne Haldosén, Feifei Yan, Amena Archer, Indranil Sinha, Chunyan Zhao, Linnea Hases
Publikováno v:
Cancer Letters. 506:23-34
The AP-1 member Fra-1 is overexpressed in TNBC and plays crucial roles in tumor progression and treatment resistance. In a previous large-scale screen, we identified PARP1 to be among 118 proteins that interact with endogenous chromatin-bound Fra-1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c99325431306d84bc4d301b5566fcb
https://doi.org/10.1016/j.canlet.2021.02.018
https://doi.org/10.1016/j.canlet.2021.02.018
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783031118357
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::829cfb8016d12f28d42c648646729093
https://doi.org/10.1007/978-3-031-11836-4_12
https://doi.org/10.1007/978-3-031-11836-4_12
Autor:
Mohammed Hakim Jafferali, Anastasios E. Damdimopoulos, Amena Archer, Dandan Song, Cecilia Williams, Linnea Hases, Rajitha Indukuri, Chunyan Zhao
Colorectal cancer (CRC) is the third leading cause of cancer death in the western world. In women, menopausal hormone therapy has been shown to reduce CRC incidence by 20%. Studies demonstrate that estrogen activating estrogen receptor beta (ERβ) pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f93ef6e9c1269586766b4178bd98a8
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-293857
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-293857
Autor:
Linnea Hases, Rajitha Indukuri, Cecilia Williams, Birgersson M, Christina Savva, Marion Korach-André, Amena Archer
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
There is a strong association between obesity and colorectal cancer (CRC), especially in men, whereas estrogen protects against both the metabolic syndrome and CRC. Colon is the first organ to respond to high-fat diet (HFD), and estrogen receptor bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0bb19c8a7dd9e0a5c006d020f5ac1a
https://pubmed.ncbi.nlm.nih.gov/32999402
https://pubmed.ncbi.nlm.nih.gov/32999402