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pro vyhledávání: '"Linnea E. Mead"'
Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1
Autor:
Mallory P. Franklin, Mark J. Graham, Linnea E. Mead, Timothy D. Heden, Kenneth K. Karanja, Bruce A. Witthuhn, Laurie L. Parker, Charles P. Najt, Douglas G. Mashek, Lisa S. Chow, Minervo Perez, Mara T. Mashek, Jason L. Heier, Salmaan A. Khan, David A. Bernlohr
Publikováno v:
Mol Cell
Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and oxidative metabolism via a SIRT1/PGC-1α/PPARα-dependent pa