Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Linnéa Bergenholm"'
Autor:
Jane Knöchel, Linnéa Bergenholm, Eman Ibrahim, Stergios Kechagias, Sara Hansson, Mathias Liljeblad, Patrik Nasr, Björn Carlsson, Mattias Ekstedt, Sebastian Ueckert
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 2038-2049 (2023)
Abstract Disease progression in nonalcoholic steatohepatitis (NASH) is highly heterogenous and remains poorly understood. Fibrosis stage is currently the best predictor for development of end‐stage liver disease and mortality. Better understanding
Externí odkaz:
https://doaj.org/article/bf1703e2ce564bf6916f27c82905c8b3
Autor:
Elke Ericson, Linnéa Bergenholm, Anne‐Christine Andréasson, Carly I. Dix, Jane Knöchel, Sara F. Hansson, Richard Lee, Jennifer Schumi, Madeleine Antonsson, Ola Fjellström, Patrik Nasr, Mathias Liljeblad, Björn Carlsson, Stergios Kechagias, Daniel Lindén, Mattias Ekstedt
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2689-2701 (2022)
Abstract In nonalcoholic fatty liver disease (NAFLD) the patatin‐like phospholipase domain‐containing 3 (PNPLA3) rs738409 variant is a contributor. In mice, the Pnpla3 148M variant accumulates on lipid droplets and probably leads to sequestration
Externí odkaz:
https://doaj.org/article/09395c29b57e4f08a41e517a3c5a8290
Autor:
Elsbet J. Pieterman, Hans M. G. Princen, Annica Jarke, Ralf Nilsson, Anders Cavallin, Linnéa Bergenholm, Marcus Henricsson, V. Sashi Gopaul, Rahul Agrawal, Steven E. Nissen, Eva Hurt-Camejo
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
We investigated the effects of chronic oral administration of mineral oil, versus corn oil as control, on intestinal permeability, inflammatory markers, and plasma lipids in APOE*3-Leiden.CETP mice. Mice received mineral oil or corn oil 15 or 30 μL/
Externí odkaz:
https://doaj.org/article/355e56a08a754992859517641f71b9b7
Autor:
Linnéa Bergenholm, David Lars Ivan Janzen, Mats Jirstrand, Joanna Parkinson, James Yates, Neil D Evans, Michael John Chappell
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Issues of parameter identifiability of routinely used pharmacodynamics models are considered in this paper. The structural identifiability of 16 commonly applied pharmacodynamic model structures was analysed analytically, using the input-output appro
Externí odkaz:
https://doaj.org/article/c0650cc4323f4c7f9ab294f0f3d3caa6
Autor:
Marcus Henricsson, Ralf Nilsson, Anders Cavallin, V. Sashi Gopaul, Eva Hurt-Camejo, Hans M.G. Princen, Linnéa Bergenholm, Steven E. Nissen, Rahul Agrawal, Annica Jarke, Elsbet J. Pieterman
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
We investigated the effects of chronic oral administration of mineral oil, versus corn oil as control, on intestinal permeability, inflammatory markers, and plasma lipids in APOE*3-Leiden.CETP mice. Mice received mineral oil or corn oil 15 or 30 μL/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874ca7b4d65c7f6b4f21c44bc734c5d2
http://europepmc.org/articles/PMC8415260
http://europepmc.org/articles/PMC8415260
Autor:
Hans M.G. Princen, Linnéa Bergenholm, Jonathan Bright, Maria Hammarberg, Eva Lundborg, Elsbet J. Pieterman, Rahul Agrawal, Glen Hawthorne, Annica Jarke, Anders Cavallin, Eva Hurt-Camejo, Bertil Abrahamsson, Rasmus Jansson-Löfmark, V. Sashi Gopaul, Magnus Johansson, Anders Björkbom, Lena Svensson, Xue-Qing Li
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 161
We investigated the effects of mineral oil on statin pharmacokinetics and inflammatory markers in animal models. A new synthesis strategy produced regioisomers that facilitated the characterization of the main metabolite (M1) of atorvastatin, a lipop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f737b1c0be3d6cf693275c5ad53007e
https://pubmed.ncbi.nlm.nih.gov/33667667
https://pubmed.ncbi.nlm.nih.gov/33667667
Autor:
Å. M. Kragh, T. Vik, Teresa Collins, Chris Pollard, Joanna Parkinson, Cecilia Arfvidsson, Corina Dota, S. Y. A. Cheung, Bengt Hamrén, Helen Tomkinson, U. Wählby-Hamrén, Linnéa Bergenholm
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 45:365-381
Drugs can affect the cardiovascular (CV) system either as an intended treatment or as an unwanted side effect. In both cases, drug-induced cardiotoxicities such as arrhythmia and unfavourable hemodynamic effects can occur, and be described using math
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb40832bc8b7e43d8199420559b24bc5
https://doi.org/10.1007/s10928-018-9589-6
https://doi.org/10.1007/s10928-018-9589-6
Autor:
Teresa Collins, Michael J. Chappell, Jay Mettetal, Neil D. Evans, Joanna Parkinson, Linnéa Bergenholm
Publikováno v:
British Journal of Pharmacology. 174:3268-3283
Background and Purpose Risk of cardiac conduction slowing (QRS/PR prolongations) is assessed prior to clinical trials using in vitro and in vivo studies. Understanding the quantitative translation of these studies to the clinical situation enables im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2df0110401b8f827f0893a04057ed5d8
https://doi.org/10.1111/bph.13940
https://doi.org/10.1111/bph.13940
Autor:
Michael J. Chappell, James W.T. Yates, Joanna Parkinson, David Janzén, Neil D. Evans, Linnéa Bergenholm, Mats Jirstrand
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Frontiers in Physiology
Frontiers in Physiology
Issues of parameter identifiability of routinely used pharmacodynamics models are considered in this paper. The structural identifiability of 16 commonly applied pharmacodynamic model structures was analyzed analytically, using the input-output appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e1b99da81bee3c2307aaead8a3dc63
http://wrap.warwick.ac.uk/83592/7/WRAP-parameter-fundamental-models-Janzen-2017.pdf
http://wrap.warwick.ac.uk/83592/7/WRAP-parameter-fundamental-models-Janzen-2017.pdf
Autor:
Elin Nyman, Linnéa Bergenholm, Eva-Maria Ekstrand, Gunnar Cedersund, Siri Fagerholm, Cecilia Brännmark, Peter Strålfors
Publikováno v:
Journal of Biological Chemistry. 288:9867-9880
Type 2 diabetes originates in an expanding adipose tissue that for unknown reasons becomes insulin resistant. Insulin resistance reflects impairments in insulin signaling, but mechanisms involved are unclear because current research is fragmented. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeb0ab9bb6ba3bd7fb9544ee9914748c
https://doi.org/10.1074/jbc.m112.432062
https://doi.org/10.1074/jbc.m112.432062