Suppression of aminoglycoside-induced premature termination codon readthrough by the TRP channel inhibitor AC1903

Autor: Isabelle B. Pickles, Sara Hosseini-Farahabadi, Claudia C. Bauer, Michel Roberge, Aruna D. Balgi, Robin S. Bon, David J. Beech, Kunho Choi, Alireza Baradaran-Heravi, Linley Dm

Nonsense mutations, which occur in ~11% of patients with genetic disorders, introduce premature termination codons (PTCs) that lead to truncated proteins and promote nonsense-mediated mRNA decay. Aminoglycosides such as gentamicin and G418 permit PTC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9eeb5b7b6aba1d3f9c296848304f6e6
https://doi.org/10.1101/2021.04.07.438788

Acoustic trauma slows AMPA receptor-mediated EPSCs in the auditory brainstem, reducing GluA4 subunit expression as a mechanism to rescue binaural function.

Autor: Pilati N; Autifony Srl Laboratories, Medicines Research Centre, 37135, Verona, Italy.; MRC Toxicology Unit, Hodgkin Bldg, University of Leicester, Leicester, LE1 9HN, UK., Linley DM; Department of Neuroscience, Psychology & Behaviour, University of Leicester, Leicester, LE1 9HN, UK., Selvaskandan H; Department of Neuroscience, Psychology & Behaviour, University of Leicester, Leicester, LE1 9HN, UK., Uchitel O; Instituto de Fisiología y Biología Molecular y Neurociencias, Universidad de Buenos Aires-CONICET, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, C1428-Buenos Aires, Argentina., Hennig MH; Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh, Edinburgh, EH8 9AB, UK.; SynthSys, C. H. Waddington Building, The Kings Buildings Campus, Edinburgh, UK., Kopp-Scheinpflug C; MRC Toxicology Unit, Hodgkin Bldg, University of Leicester, Leicester, LE1 9HN, UK.; Department of Biology II, Ludwig-Maximilians-Universität München, Planegg-Martinsried, D-82152, Munich, Germany., Forsythe ID; MRC Toxicology Unit, Hodgkin Bldg, University of Leicester, Leicester, LE1 9HN, UK.; Department of Neuroscience, Psychology & Behaviour, University of Leicester, Leicester, LE1 9HN, UK.

Publikováno v: The Journal of physiology [J Physiol] 2016 Jul 01; Vol. 594 (13), pp. 3683-703. Date of Electronic Publication: 2016 Jun 09.