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Akademický článek

Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway

Autor: Haohao Liu, Xin Zeng, Ya Ma, Xinghai Chen, Michael D. Losiewicz, Xingde Du, Zhihui Tian, Shiyu Zhang, Linjia Shi, Huizhen Zhang, Fei Yang

Publikováno v: Ecotoxicology and Environmental Safety, Vol 236, Iss , Pp 113454- (2022)

Microcystin-leucine arginine (MC-LR), an emerging water pollutant, produced by cyanobacteria, has an acute testicular toxicity. However, little is known about the chronic toxic effects of MC-LR exposure on the testis at environmental concentrations a

Externí odkaz: https://doaj.org/article/cc2641dcab2146f8978d26e694aeecaf

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Akademický článek

The activated ATM/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells

Autor: Zhihui Tian, Haohao Liu, Xinghai Chen, Michael D. Losiewicz, Rui Wang, Xingde Du, Bingqian Wang, Ya Ma, Shiyu Zhang, Linjia Shi, Xing Guo, Yongshui Wang, Bingyu Zhang, Shumeng Yuan, Xin Zeng, Huizhen Zhang

Publikováno v: Ecotoxicology and Environmental Safety, Vol 227, Iss , Pp 112919- (2021)

Microcystin-LR (MC-LR) is an intracellular toxin with multi-organ toxicity and the testis is one of its important target organs. Although there is increasing research on MC-LR in male reproductive toxicity, the association between DNA damage and auto

Externí odkaz: https://doaj.org/article/2bde358b27514e6ca45bc28180cfbc4c

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Akademický článek

Advances in the toxicology research of microcystins based on Omics approaches

Autor: Ya Ma, Haohao Liu, Xingde Du, Ziang Shi, Xiaohui Liu, Rui Wang, Shiyu Zhang, Zhihui Tian, Linjia Shi, Hongxiang Guo, Huizhen Zhang

Publikováno v: Environment International, Vol 154, Iss , Pp 106661- (2021)

Microcystins (MCs) are the most widely distributed cyanotoxins, which can be ingested by animals and human body in multiple ways, resulting in a threat to human health and the biodiversity of wildlife. Therefore, the study on toxic effects and mechan

Externí odkaz: https://doaj.org/article/34ef37b39d8a4dd0ba22478836231be5

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Akademický článek

Microcystin-LR induces ovarian injury and apoptosis in mice via activating apoptosis signal-regulating kinase 1-mediated P38/JNK pathway

Autor: Xingde Du, Haohao Liu, Xiaohui Liu, Xinghai Chen, Le Yuan, Ya Ma, Hui Huang, Yueqin Wang, Rui Wang, Shiyu Zhang, Zhihui Tian, Linjia Shi, Huizhen Zhang

Publikováno v: Ecotoxicology and Environmental Safety, Vol 213, Iss , Pp 112066- (2021)

As an emerging pollutant in the aquatic environment, microcystin-LR (MC-LR) can enter the body through multiple pathways, and then induce apoptosis and gonadal damage, affecting reproductive function. Previous studies focused on male reproductive tox

Externí odkaz: https://doaj.org/article/9227ae26d98d49f69a81e32eab83ccc6

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PI3K/AKT/mTOR pathway mediated-cell cycle dysregulation contribute to malignant proliferation of mouse spermatogonia induced by microcystin-leucine arginine

Autor: Xingde Du, Haohao Liu, Zhihui Tian, Shiyu Zhang, Linjia Shi, Yongshui Wang, Xing Guo, Bingyu Zhang, Shumeng Yuan, Xin Zeng, Huizhen Zhang

Publikováno v: Environmental toxicologyREFERENCES.

Environmental cyanotoxin exposure may be a trigger of testicular cancer. Activation of PI3K/AKT/mTOR signaling pathway is the critical molecular event in testicular carcinogenesis. As a widespread cyanotoxin, microcystin-leucine arginine (MC-LR) is k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375ecced18d861f1fa977bf3bd58442d
https://pubmed.ncbi.nlm.nih.gov/36288207

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MicroRNA-122 overexpression promotes apoptosis and tumor suppressor gene expression induced by microcystin-leucine arginine in mouse liver

Autor: Shiyu Zhang, Rui Wang, Linjia Shi, Xingde Du, Ya Ma, Huizhen Zhang, Zhihui Tian, Hongxiang Guo, Haohao Liu

Publikováno v: International Journal of Environmental Health Research. 32:2123-2134

Microcystin-leucine arginine (MC-LR), an important hepatoxin, has the effect of promoting hepatocarcinogenesis. MicroRNA-122 (miR-122), an important tumor suppressor in liver, plays an important role in promoting cell apoptosis. Previous studies foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc3ad2426dea3e9ffe4da5774cfe1e3
https://doi.org/10.1080/09603123.2021.1946489

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A new identity of microcystins: Environmental endocrine disruptors? An evidence-based review

Autor: Shiyu Zhang, Haohao Liu, Xingde Du, Xinghai Chen, Pavankumar Petlulu, Zhihui Tian, Linjia Shi, Bingyu Zhang, Shumeng Yuan, Xing Guo, Yongshui Wang, Hongxiang Guo, Huizhen Zhang

Publikováno v: The Science of the total environment. 851(Pt 2)

Microcystins (MCs) are widely distributed cyanobacterial toxins in eutrophic waters. At present, the endocrine-disrupting effects of MCs have been extensively studied, but whether MCs can be classified as environmental endocrine disruptors (EDCs) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c740e2e03bcdbd16c6084a5865f43d9
https://pubmed.ncbi.nlm.nih.gov/36029820

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