Zobrazeno 1 - 10
of 626
pro vyhledávání: '"Lining Zhang"'
Autor:
Baihui Cao, Xiaotong Chen, Yubin Li, Tian Zhou, Nuo Chen, Yaxin Guo, Ming Zhao, Chun Guo, Yongyu Shi, Qun Wang, Xuexiang Du, Lining Zhang, Yan Li
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract TFE3 and TFEB, as the master regulators of lysosome biogenesis and autophagy, are well characterized to enhance the synaptic protein α-synuclein degradation in protecting against Parkinson’s disease (PD) and their levels are significantly
Externí odkaz:
https://doaj.org/article/d34e10598fa84854b4b290b010860c15
Autor:
Nuo Chen, Xiaoyu Wang, Yaxin Guo, Ming Zhao, Baihui Cao, Bing Zhan, Yubin Li, Tian Zhou, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Lining Zhang, Yan Li
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Tuberous sclerosis complex 2 (TSC2) crucially suppresses Rheb activity to prevent mTORC1 activation. However, mutations in TSC genes lead to mTORC1 overactivation, thereby causing various developmental disorders and cancer. Therefore, the di
Externí odkaz:
https://doaj.org/article/642c79be80334573bdcf7898b8170d4e
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract The dysregulation of pro- and anti-inflammatory processes in the brain has been linked to the pathogenesis of major depressive disorder (MDD), although the precise mechanisms remain unclear. In this study, we discovered that microglial condi
Externí odkaz:
https://doaj.org/article/d5ad93d748ad41fc8b1959e31c25eff1
Autor:
Hongxia Yang, Qingning Chen, Chao Sun, Qiwen Jin, Lining Zhang, Qingyan Liu, Qinglin Peng, Guochun Wang, Xin Lu
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Objective To investigate the association of serum anti-Jo-1 antibody levels with the disease activity and prognosis in anti-Jo-1-positive patients with antisynthetase syndrome (ASS). Methods This study included 115 anti-Jo-1-positive patient
Externí odkaz:
https://doaj.org/article/adeaccf4610b42bf84c315365ad4b8f5
Autor:
Yaxin Guo, Nuo Chen, Ming Zhao, Baihui Cao, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Yan Li, Lining Zhang
Publikováno v:
Pharmacological Research, Vol 202, Iss , Pp 107136- (2024)
CREB-regulated transcription coactivator 1 (CRTC1), a pivotal synaptonuclear messenger, regulates synaptic plasticity and transmission to prevent depression. Despite exhaustive investigations into CRTC1 mRNA reductions in the depressed mice, the regu
Externí odkaz:
https://doaj.org/article/9683cdaf52804edab520d7e8c21e83d2
Autor:
Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, WanJun Chen, Yan Li, Lining Zhang
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The potentiation of synaptic plasticity and serotonin generation by brain-derived neurotrophic factor (BDNF) and tryptophan hydroxylase 2 (TPH2) is well characterized to facilitate rapid and long-lasting antidepressant actions. Therefore, th
Externí odkaz:
https://doaj.org/article/c2a2f8e282624ca98581fb66783e7f9c
Publikováno v:
Shipin gongye ke-ji, Vol 44, Iss 22, Pp 275-284 (2023)
Sargassum fusiforme is rich in a variety of nutrients and active substances, and is one of the important economic seaweeds in China. Its quality could be easily affected by environmental factors such as marine areas. To figure out the differences in
Externí odkaz:
https://doaj.org/article/cba2b5137ff440a69330c78d15c1a617
Publikováno v:
Materials, Vol 17, Iss 12, p 2945 (2024)
Polypropylene fiber reinforcement is an effective method to enhance the durability of concrete structures. With the increasing public interest in the widespread use of polypropylene fiber reinforced concrete (PFRC), the necessity of evaluating the me
Externí odkaz:
https://doaj.org/article/b7ec6566cdc84b4babf23c681df139c4
Autor:
Yaxin Guo, Yi Zhang, Yetong Guan, Nuo Chen, Ming Zhao, Yubin Li, Tian Zhou, Xinyue Zhang, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Lining Zhang, Yan Li
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113787- (2024)
Summary: The spontaneous migration of bone marrow neutrophils (BMNs) is typically induced by distant tumor cells during the early stage of the tumor and critically controls tumor progression and metastases. Therefore, identifying the key molecule tha
Externí odkaz:
https://doaj.org/article/70d6be4091e8435582592580e82c0577
Autor:
Nuo Chen, Xinyi Xu, Yaxin Guo, Ming Zhao, Yubin Li, Tian Zhou, Xinyue Zhang, Jie Gao, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Wenxian Wu, Lining Zhang, Yan Li
Publikováno v:
Research, Vol 7 (2024)
Short-chain fatty acids (SCFAs) have been increasingly evidenced to be important bioactive metabolites of the gut microbiota and transducers in controlling diverse psychiatric or neurological disorders via the microbiota–gut–brain axis. However,
Externí odkaz:
https://doaj.org/article/63de0d8c5e1543669096016db62b428c