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Akademický článek

A herpes simplex virus 2 (HSV-2) glycoprotein D-expressing nonreplicating dominant-negative HSV-2 virus vaccine is superior to a gD2 subunit vaccine against HSV-2 genital infection in guinea pigs.

Autor: Pengwei Zhang, Lining Xie, John W Balliet, Danilo R Casimiro, Feng Yao

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e101373 (2014)

We recently constructed a novel non-replicating dominant-negative HSV-2 recombinant viral vaccine (CJ2-gD2) capable of expressing various HSV-2 antigens that are dominant targets of HSV-2-specific CD8 T-cell response. Importantly, CJ2-gD2 expresses g

Externí odkaz: https://doaj.org/article/d58c00fe094848339728088feb4a8a7a

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Expression of CD10 predicts tumor progression and unfavorable prognosis in malignant melanoma

Autor: Masakazu Takahara, Shogo Miyazaki, Sayaka Hayashida, Takeshi Nakahara, Yoichi Moroi, Akihito Hagihara, Lining Xie, Makiko Kido, Hiroshi Uchi, Takeru Abe, Masutaka Furue, Junna Oba

Publikováno v: Journal of the American Academy of Dermatology. 65:1152-1160

CD10 expression in malignant melanoma (MM) has been reported to increase according to tumor progression and metastasis; however, its association with patient outcome has not been clarified.We examined the immunohistochemical expression of CD10 in MM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e5ff768a5a3a0a9546ea8e8edf3d7d
https://doi.org/10.1016/j.jaad.2010.10.019

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Hematopoietic Progenitor Kinase 1, Mitogen-Activated Protein/Extracellular Signal-Related Protein Kinase Kinase Kinase 1, and phosphoMitogen-Activated Protein Kinase Kinase 4 are Overexpressed in Extramammary Paget Disease

Autor: Yue Qian, Satoshi Takeuchi, Masutaka Furue, Takeshi Nakahara, Ya Ting Tu, Masakazu Takahara, Lining Xie, Long Dugu, Yoichi Moroi, Gaku Tsuji

Publikováno v: The American Journal of Dermatopathology. 33:681-686

The c-Jun amino-terminal kinase (JNK) pathway seems to play important roles in the pathogenesis of several tumors, but its significance in extramammary Paget disease (EMPD) has not been investigated yet. The purpose of the study was to investigate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ceeb7b1eada1f239681a9913ef0923e
https://doi.org/10.1097/dad.0b013e318215c3fb

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Loss of Wnt-5α is associated with an invasive phenotype of extramammary Paget's disease

Autor: Sayaka Hayashida, Masutaka Furue, Lining Xie

Publikováno v: Journal of Cutaneous Pathology. 38:576-580

Background: The Wnt (wingless-type MMTV integration site) gene family encodes secretory signaling molecules that play a diverse biological role in the regulation of normal and pathological processes, including cell growth, differentiation and oncogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1624d3d553b6f9ad0ea8aedc7a8ff109
https://doi.org/10.1111/j.1600-0560.2011.01689.x

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Stromal expression of cathepsin K in squamous cell carcinoma

Autor: Xiaofeng Yan, Satoshi Takeuchi, T. Nakahara, Masutaka Furue, Lining Xie, Masakazu Takahara, Yating Tu, Yoshinao Oda, Yoichi Moroi, Hiroshi Uchi

Publikováno v: Journal of the European Academy of Dermatology and Venereology. 25:362-365

Background Cathepsin K (CTSK), a cysteine protease with strong collagenolytic and elastolytic properties involved in extracellular matrix turnover, may be produced by neoplastic cells as well as stromal macrophages and fibroblasts. Its expression is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::641e6237dbe55237c933fd35f9663702
https://doi.org/10.1111/j.1468-3083.2010.03743.x

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Cathepsin K-upregulation in fibroblasts promotes matrigel invasive ability of squamous cell carcinoma cells via tumor-derived IL-1α

Autor: Hiroshi Uchi, Masutaka Furue, Satoshi Takeuchi, Takeshi Nakahara, Masakazu Takahara, Sayaka Hayashida, Lining Xie, Baoen Shan, Yoichi Moroi, Gaku Tsuji

Publikováno v: Journal of Dermatological Science. 61(1):45-50

Background Cathepsin K (CTSK), a cysteine protease with strong collagenolytic properties, is involved in extracellular matrix turnover. In the previous studies, CTSK expression was detected in peritumoral fibroblasts (Fbs) around squamous cell carcin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492b56cba0200711b3f49eae0868236d
http://hdl.handle.net/2324/25443

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Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects

Autor: Wenguo Zhao, Weiping Gao, Jin Hu, Lining Xie, Xinyu Liu, Mengmeng Sun

Publikováno v: Chemical communications (Cambridge, England). 51(57)

Tumor-homing and pH-responsive polypeptide-drug nanoparticles for targeted cancer therapy are precisely designed by site-specific drug conjugation to a bioactive and well-defined elastin-like polypeptide through an acid-labile linker. In a murine can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a39b38ce77e1d9b835d4b70fb4b38e
https://pubmed.ncbi.nlm.nih.gov/26086450

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