Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lining Lu"'
Publikováno v:
mLife, Vol 3, Iss 1, Pp 87-100 (2024)
Abstract Insertion sequences (ISs) exist widely in bacterial genomes, but their roles in the evolution of bacterial antiphage defense remain to be clarified. Here, we report that, under the pressure of phage infection, the IS1096 transposition of Myc
Externí odkaz:
https://doaj.org/article/3b18250b98c848c492b81f208d123191
Autor:
Lining Lu, Xiaoguo Zhai, Xiaolong Li, Shuansuo Wang, Lijun Zhang, Luyang Wang, Xi Jin, Lujun Liang, Zhiheng Deng, Zichen Li, Yanfeng Wang, Xiangdong Fu, Honggang Hu, Jiawei Wang, Ziqing Mei, Zhengguo He, Feng Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Deubiquitinases (DUBs) targeting Met1-linked ubiquitin chains have important functions in mammals but are barely studied in plants. Here, the authors identify rice OTUB1 as a Met1-targeting DUB, characterize the structural determinants of this activi
Externí odkaz:
https://doaj.org/article/e514a51f661245e3ac65fb1d14ad214b
Autor:
Wen-Hao Zhang, Jia-Bin Li, Sanling Liu, Qian Qu, Changlin Tian, Shuai Gao, Huan Lan, Lei Liu, Qingyun Zheng, Lining Lu, Jiawei Wang, Yulei Li, Yi-Ming Li, Yuanyuan Yu, Tian Wang, Ming Wu, Demeng Sun, Man Pan, Honggang Hu
Publikováno v:
CCS Chemistry. 1:476-489
Mutations in genes encoding PINK1 (PTEN-induced kinase 1) and Parkin (E3 ubiquitin ligase) are identified in familial Parkinson’s disease. However, it remains unclear whether the phosphorylated Ub ...
Publikováno v:
Science China Chemistry. 63:237-243
MINDY-1 is a recently discovered new family of deubiquitinating enzymes (DUB), but one of its yeast homologs, YGL082W, does not show any DUB activity in vitro. Sequence alignment shows that YGL082W possesses the correct catalytic triad, and yet did n
Publikováno v:
Journal of Molecular Biology. 434:167634
Ubiquitination, an important posttranslational modification, participates in virtually all aspects of cellular functions and is reversed by deubiquitinating enzymes (DUBs). Ubiquitin-specific protease 34 (USP34) plays an essential role in cancer, neu
Met1 type ubiquitination and deubiquitination are involved in the regulation of many fundamental processes such as inflammation and innate immunity, and their interference by pathogens can suppress immune responses in human cells. However, no plant-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebc9e00e45f515df1498edc6a8d137b2
https://doi.org/10.21203/rs.3.rs-199392/v1
https://doi.org/10.21203/rs.3.rs-199392/v1
Autor:
Lining Lu, Xiaoguo Zhai, Xiaolong Li, Shuansuo Wang, Lijun Zhang, Luyang Wang, Xi Jin, Lujun Liang, Zhiheng Deng, Zichen Li, Yanfeng Wang, Xiangdong Fu, Honggang Hu, Jiawei Wang, Ziqing Mei, Zhengguo He, Feng Wang
Publikováno v:
Nature communications. 13(1)
Linear (Met1-linked) ubiquitination is involved inflammatory and innate immune signaling. Previous studies have characterized enzymes regulating the addition and removal of this modification in mammalian systems. However, only a few plant-derived deu
Autor:
Zongwei Yue, Olivia Stovicek, Yi Qin Gao, Chengqi Yi, Shuai Zong, Chenxu Zhu, Lining Lu, Jun Zhang, Menghao Liu, Jinghui Song
Publikováno v:
Proceedings of the National Academy of Sciences. 113:7792-7797
NEIL1 (Nei-like 1) is a DNA repair glycosylase guarding the mammalian genome against oxidized DNA bases. As the first enzymes in the base-excision repair pathway, glycosylases must recognize the cognate substrates and catalyze their excision. Here we
Autor:
Xiaodan Tan, Shuai Gao, Lei Liu, Jiawei Wang, Huan Lan, Qingyun Zheng, Tian Wang, Yi-Chao Huang, Man Pan, Yong Zheng, Xiang-Long Tan, Lining Lu, Demeng Sun
Publikováno v:
Journal of the American Chemical Society. 138:7429-7435
Quasi-racemic crystallography has been used to determine the X-ray structures of K27-linked ubiquitin (Ub) chains prepared through total chemical synthesis. Crystal structures of K27-linked di- and tri-ubiquitins reveal that the isopeptide linkages a
Autor:
Shuai Gao, Man Pan, Yong Zheng, Yichao Huang, Qingyun Zheng, Demeng Sun, Lining Lu, Xiaodan Tan, Xianglong Tan, Huan Lan, Jiaxing Wang, Tian Wang, Jiawei Wang, Lei Liu
Publikováno v:
Journal of the American Chemical Society. 138(43)
Racemic or quasi-racemic crystallography recently emerges as a useful technology for solution of the crystal structures of biomacromolecules. It remains unclear to what extent the biomacromolecules of opposite handedness can differ from each other in