Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Lining Arnold Ju"'
Autor:
Haoqing Jerry Wang, Yao Wang, Seyed Sajad Mirjavadi, Tomas Andersen, Laura Moldovan, Parham Vatankhah, Blake Russell, Jasmine Jin, Zijing Zhou, Qing Li, Charles D. Cox, Qian Peter Su, Lining Arnold Ju
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The microgeometry of the cellular microenvironment profoundly impacts cellular behaviors, yet the link between it and the ubiquitously expressed mechanosensitive ion channel PIEZO1 remains unclear. Herein, we describe a fluorescent micropipe
Externí odkaz:
https://doaj.org/article/832d8eaab86449c8bbae7b7e5b509f79
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Fluorescence nanoscopy, also known as super-resolution microscopy, has transcended the conventional resolution barriers and enabled visualization of biological samples at nanometric resolutions. A series of super-resolution techniques have b
Externí odkaz:
https://doaj.org/article/20e685981f4a4798839b6b501625f9b8
Autor:
Tiffany Goh, Lingzi Gao, Jasneil Singh, Richard Totaro, Ruaidhri Carey, Kevin Yang, Bruce Cartwright, Mark Dennis, Lining Arnold Ju, Anna Waterhouse
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract Use of extracorporeal membrane oxygenation (ECMO) for cardiorespiratory failure remains complicated by blood clot formation (thrombosis), triggered by biomaterial surfaces and flow conditions. Thrombosis may result in ECMO circuit changes, c
Externí odkaz:
https://doaj.org/article/cb6ad2d6e74a48f39889ab15ea5a2828
Autor:
Yunduo Charles Zhao, Yingqi Zhang, Arian Nasser, Tianbo Hong, Zihao Wang, Allan Sun, Laura Moldovan, Leon S Edwards, Freda Passam, Ken S Butcher, Timothy Ang, Lining Arnold Ju
Publikováno v:
Aggregate, Vol 4, Iss 6, Pp n/a-n/a (2023)
Abstract Cerebral venous sinus thrombosis (CVST) is a type of stroke associated with COVID‐19 vaccine‐induced immune thrombotic thrombocytopenia. The precise etiology of CVST often remains elusive due to the highly heterogeneous nature of its gov
Externí odkaz:
https://doaj.org/article/1420338956634ed49e84ecb7d5fb17bb
Autor:
Yingqi Zhang, San‐Seint‐Seint Aye, Vivian Cheng, Arian Nasser, Tianbo Hong, Parham Vatankhah, Fengtao Jiang, Yunduo Charles Zhao, Laura Moldovan, Allan Sun, Alexander Dupuy, Yao Wang, Zhiyong Li, Timothy Ang, Freda Passam, Ken‐Tye Yong, Lining Arnold Ju
Publikováno v:
Advanced Materials Interfaces, Vol 10, Iss 29, Pp n/a-n/a (2023)
Abstract Stenosis, characterized by partial vessel narrowing, alters blood hemodynamics and can lead to unpredictable thrombosis. Existing models struggle to accurately represent the complex vascular geometries and hemodynamics involved in such condi
Externí odkaz:
https://doaj.org/article/5370e1d166cd42109c4115e3a18b3132
Autor:
Laura Moldovan, Caroline Haoran Song, Yiyao Catherine Chen, Haoqing Jerry Wang, Lining Arnold Ju
Publikováno v:
Exploration, Vol 3, Iss 4, Pp n/a-n/a (2023)
Abstract Mechanical forces play a vital role in biological processes at molecular and cellular levels, significantly impacting various diseases such as cancer, cardiovascular disease, and COVID‐19. Recent advancements in dynamic force spectroscopy
Externí odkaz:
https://doaj.org/article/07bf3ddc99b5453dbc1ec6c9f6e4375f
Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
Autor:
Jinyuan Vero Li, Chai-Ann Ng, Delfine Cheng, Zijing Zhou, Mingxi Yao, Yang Guo, Ze-Yan Yu, Yogambha Ramaswamy, Lining Arnold Ju, Philip W. Kuchel, Michael P. Feneley, Diane Fatkin, Charles D. Cox
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Li et al. investigates the role of N-linked glycosylation for the function of mechanosensitive ion channel Piezo1. They show that disease-linked loss of function mutations in Piezo1 that are trafficking defective lack N-linked glycosylation.
Externí odkaz:
https://doaj.org/article/838c42e3bd25417ab25bf8adfdc60922
Autor:
Yunduo Charles Zhao, Parham Vatankhah, Tiffany Goh, Rhys Michelis, Kiarash Kyanian, Yingqi Zhang, Zhiyong Li, Lining Arnold Ju
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Disturbed blood flow has been increasingly recognized for its critical role in platelet aggregation and thrombosis. Microfluidics with hump shaped contractions have been developed to mimic microvascular stenosis and recapitulate the prothrom
Externí odkaz:
https://doaj.org/article/144cd1e9419546d2a28ebc8a1d1c5e99
Publikováno v:
Frontiers in Physics, Vol 10 (2022)
Cells sense and respond to mechanical stimuli for activation, proliferation, migration, and differentiation. The associated mechanosensing and biomechanical properties of cells and tissues are significantly implicated in the context of cancer, fibros
Externí odkaz:
https://doaj.org/article/7e15459c485c48f0a7101dcf7d7e4e2b
Publikováno v:
Biosensors, Vol 13, Iss 1, p 95 (2023)
Cancer cells interacting with the extracellular matrix (ECM) in the tumor microenvironment is pivotal for tumorigenesis, invasion, and metastasis. Cell–ECM adhesion has been intensively studied in cancer biology in the past decades to understand th
Externí odkaz:
https://doaj.org/article/d4afce5204ca4428b619ef1befa5a5a6