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Akademický článek

Linifanib induces apoptosis in human ovarian cancer cells via activation of FOXO3 and reactive oxygen species

Autor: Chang Min Lee, Jongsung Lee, Mi-Ae Kang, Hee Taek Kim, Jongbok Lee, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang, See-Hyoung Park

Publikováno v: Arabian Journal of Chemistry, Vol 15, Iss 12, Pp 104321- (2022)

Linifanib is known as an inhibitor of receptor tyrosine kinase. Even though it has been widely recognized as efficient inhibitor of receptor tyrosine kinases, anti-carcinogenic effect has not been investigated enough in ovarian cancer. In this study,

Externí odkaz: https://doaj.org/article/03ba689a544848a89722ac0934b1337c

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Akademický článek

Charge-Transfer Complex of Linifanib with 2,3-dichloro-3,5-dicyano-1,4-benzoquinone: Synthesis, Spectroscopic Characterization, Computational Molecular Modelling and Application in the Development of Novel 96-microwell Spectrophotometric Assay

Autor: Darwish IA, Khalil NY, Alsaif NA, Herqash RN, Sayed AYA, Abdel-Rahman HM

Publikováno v: Drug Design, Development and Therapy, Vol Volume 15, Pp 1167-1180 (2021)

Ibrahim A Darwish,1 Nasr Y Khalil,1 Nawaf A Alsaif,1 Rashed N Herqash,2 Ahmed YA Sayed,1 Hamdy M Abdel-Rahman3,4 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia; 2Medicinal Aromatic and

Externí odkaz: https://doaj.org/article/577ebb7fd8c94524918a0524089ee4a0

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Akademický článek

Proliferation mechanism of acute myeloid leukemia cell line GDM-1 with CSF1R-Y571D mutation

Autor: CAO Qiong, XU Ning-xin, LI Xiao-wen, WU Hao, HAO Jian-qing, QIN Yan-hong, LI Li

Publikováno v: Jichu yixue yu linchuang, Vol 41, Iss 1, Pp 44-49 (2021)

Objective To explore the proliferation mechanism of acute myeloid leukemia cell line GDM-1 by the method of protein kinase inhibition. Methods GDM-1 cells were divided into experimental group and control group according to different treatment. Experi

Externí odkaz: https://doaj.org/article/18a75898448b477babab45259d949d11

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Akademický článek

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Selection of first-line systemic therapies for advanced hepatocellular carcinoma: A network meta-analysis of randomized controlled trials

Autor: Wei-Hua Zhi, Yue Han, Xiao-Qian Huang, Jianfeng Luo, Fei Xu, Chen-Bo Zhang

Publikováno v: World Journal of Gastroenterology

Background The majority of clinical trials of first-line systemic treatments for hepatocellular carcinoma (HCC) used placebo or sorafenib as comparators, and there are limited data providing a cross comparison of treatments in this setting, especiall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46ca0702ab51d7dcd434fc2d9467b46
https://doi.org/10.3748/wjg.v27.i19.2415

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Profile of lenvatinib in the treatment of hepatocellular carcinoma: design, development, potential place in therapy and network meta-analysis of hepatitis B and hepatitis C in all Phase III trials

Autor: Emiliano Tamburini, Fabio Conti, Mario Scartozzi, Andrea Casadei Gardini, Marco Puzzoni, Francesco Giuseppe Foschi, Leonardo Solaini, Stefano Cascinu, Giorgia Marisi, Giorgio Ercolani, Francesco Montagnani, Alessandro Cucchetti

Publikováno v: OncoTargets and therapy

Andrea Casadei Gardini,1* Marco Puzzoni,2* Francesco Montagnani,3* Giorgia Marisi,4* Emiliano Tamburini,5 Alessandro Cucchetti,6,7 Leonardo Solaini,6,7 Francesco Giuseppe Foschi,8 Fabio Conti,8 Giorgio Ercolani,6,7 Stefano Cascinu,1 Mario Scartozzi21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11392e592ce955bb2053647d06c3bf29
https://doi.org/10.2147/ott.s192572

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Development of 96-microwell Plate Assay with Fluorescence Reader and HPLC Method with Fluorescence Detection for High-throughput Analysis of Linifanib in its Bulk and Dosage Forms

Autor: Ibrahim A. Darwish, Mamdouh Alanazi, Mohammed A. Hamidaddin, Nasr Y. Khalil

Publikováno v: Current Pharmaceutical Analysis. 17:285-292

Background: Linifanib (LFB) is a tyrosine kinase inhibitor with antineoplastic activity. The existing methods for the analysis of LFB in bulk and dosage forms do not meet the requirements of quality control (QC) analysis. Objective: The present study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69a52d9dd558153bdafae889ff625dbb
https://doi.org/10.2174/1573412917999200925204910

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Current progress, challenges and future prospects of indazoles as protein kinase inhibitors for the treatment of cancer

Autor: Nitin Tandon, Vijay Luxami, Kamaldeep Paul, Divya Kant, Runjhun Tandon

Publikováno v: RSC Advances. 11:25228-25257

The indazole core is an interesting pharmacophore due to its applications in medicinal chemistry. In the past few years, this moiety has been used for the synthesis of kinase inhibitors. Many researchers have demonstrated the use of indazole derivati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb50ebc04a2b9fadbe772f765e6242bf
https://doi.org/10.1039/d1ra03979b

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