Ziftomenib in relapsed or refractory acute myeloid leukaemia (KOMET-001): a multicentre, open-label, multi-cohort, phase 1 trial.

Autor: Wang ES; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Electronic address: eunice.wang@roswellpark.org., Issa GC; MD Anderson Cancer Center, Houston, TX, USA., Erba HP; Duke Cancer Institute, Durham, NC, USA., Altman JK; Northwestern University-Robert H Lurie Comprehensive Cancer Center, Chicago, IL, USA., Montesinos P; Hospital Universitari i Politècnic La Fe, Valencia, Spain., DeBotton S; Institut Gustave Roussy Service d'Hématologie Clinique, Paris, France., Walter RB; Fred Hutchinson Cancer Center, Seattle, WA, USA., Pettit K; University of Michigan, Ann Arbor, MI, USA., Savona MR; Vanderbilt-Ingram Cancer Center, Nashville, TN, USA., Shah MV; Mayo Clinic, Rochester, MN, USA., Kremyanskaya M; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Baer MR; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA., Foran JM; Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA., Schiller G; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Adès L; Hôpital Saint-Louis (AP-HP) and Université Paris Cité and Centre d'Investigations Cliniques-Inserm CIC-1427, Paris, France., Heiblig M; Centre Hospitalier Lyon Sud, Lyon, France., Berthon C; Centre Hospitalo-Universitaire Lille, Lille, France., Peterlin P; CHU de Nantes-Hôtel-Dieu, Nantes, France., Rodríguez-Arbolí E; Department of Hematology, Hospital Universitario Virgen del Rocío, Seville Biomedicine Institute (IBiS/CSIC), University of Seville, Seville, Spain., Salamero O; Servei d'Hematologia de l'Hospital Vall d'Hebron i Unitat d'Hematología Experimental del Vall d'Hebron Institut d'Oncología, Facultat de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain., Patnaik MM; Mayo Clinic, Rochester, MN, USA., Papayannidis C; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Bologna, Italy., Grembecka J; University of Michigan, Ann Arbor, MI, USA., Cierpicki T; University of Michigan, Ann Arbor, MI, USA., Clegg B; University of Michigan, Ann Arbor, MI, USA., Ray J; University of Michigan, Ann Arbor, MI, USA., Linhares BM; University of Michigan, Ann Arbor, MI, USA., Nie K; Kura Oncology, Inc, San Diego, CA, USA., Mitra A; Kura Oncology, Inc, San Diego, CA, USA., Ahsan JM; Kura Oncology, Inc, San Diego, CA, USA., Tabachri M; Kura Oncology, Inc, San Diego, CA, USA., Soifer HS; Kura Oncology, Inc, San Diego, CA, USA., Corum D; Kura Oncology, Inc, San Diego, CA, USA., Leoni M; Kura Oncology, Inc, San Diego, CA, USA., Dale S; Kura Oncology, Inc, San Diego, CA, USA., Fathi AT; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Publikováno v: The Lancet. Oncology [Lancet Oncol] 2024 Oct; Vol. 25 (10), pp. 1310-1324.

Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury.

Autor: Chase DH; Department of Chemistry, Yale University, New Haven, CT-06511., Bebenek AM; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT-06511., Nie P; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT-06511., Jaime-Figueroa S; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT-06511., Butrin A; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT-06511., Castro DA; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT-06511., Hines J; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT-06511., Linhares BM; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT-06511., Crews CM; Department of Chemistry, Yale University, New Haven, CT-06511.; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT-06511.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Apr 02; Vol. 63 (14), pp. e202316496. Date of Electronic Publication: 2024 Feb 28.

Development of potent dimeric inhibitors of GAS41 YEATS domain.

Autor: Listunov D; Department of Pathology, University of Michigan, 1150 West Medical Center Dr, MSRB I, Room 4510D, Ann Arbor, MI 48108, USA., Linhares BM; Department of Pathology, University of Michigan, 1150 West Medical Center Dr, MSRB I, Room 4510D, Ann Arbor, MI 48108, USA., Kim E; Department of Pathology, University of Michigan, 1150 West Medical Center Dr, MSRB I, Room 4510D, Ann Arbor, MI 48108, USA., Winkler A; Department of Pathology, University of Michigan, 1150 West Medical Center Dr, MSRB I, Room 4510D, Ann Arbor, MI 48108, USA., Simes ML; Department of Pathology, University of Michigan, 1150 West Medical Center Dr, MSRB I, Room 4510D, Ann Arbor, MI 48108, USA., Weaver S; Department of Pathology, University of Michigan, 1150 West Medical Center Dr, MSRB I, Room 4510D, Ann Arbor, MI 48108, USA., Cho HJ; Department of Pathology, University of Michigan, 1150 West Medical Center Dr, MSRB I, Room 4510D, Ann Arbor, MI 48108, USA., Rizo A; Department of Pathology, University of Michigan, 1150 West Medical Center Dr, MSRB I, Room 4510D, Ann Arbor, MI 48108, USA., Zolov S; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2670, USA., Keshamouni VG; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2670, USA., Grembecka J; Department of Pathology, University of Michigan, 1150 West Medical Center Dr, MSRB I, Room 4510D, Ann Arbor, MI 48108, USA. Electronic address: jolantag@umich.edu., Cierpicki T; Department of Pathology, University of Michigan, 1150 West Medical Center Dr, MSRB I, Room 4510D, Ann Arbor, MI 48108, USA. Electronic address: tomaszc@umich.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2021 Dec 16; Vol. 28 (12), pp. 1716-1727.e6. Date of Electronic Publication: 2021 Jul 21.

Unexpected specificity within dynamic transcriptional protein-protein complexes.

Autor: Henley MJ; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109., Linhares BM; Department of Biophysics, University of Michigan, Ann Arbor, MI 48109., Morgan BS; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109., Cierpicki T; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109.; Department of Biophysics, University of Michigan, Ann Arbor, MI 48109.; Department of Pathology, University of Michigan, Ann Arbor, MI 48109., Fierke CA; Department of Chemistry, Texas A&M University, College Station, TX 77843., Mapp AK; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109; amapp@umich.edu.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 03; Vol. 117 (44), pp. 27346-27353. Date of Electronic Publication: 2020 Oct 19.

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.

Autor: Klossowski S; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Miao H; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Kempinska K; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Wu T; Wellspring Biosciences, Inc., San Diego, California, USA., Purohit T; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Kim E; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Linhares BM; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Chen D; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Jih G; Life Sciences Institute and., Perkey E; Life Sciences Institute and., Huang H; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., He M; College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA., Wen B; College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA., Wang Y; Wellspring Biosciences, Inc., San Diego, California, USA., Yu K; Wellspring Biosciences, Inc., San Diego, California, USA., Lee SC; Memorial Sloan Kettering Cancer Center, New York, New York, USA., Danet-Desnoyers G; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Trotman W; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Kandarpa M; Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Cotton A; Saint Jude Children's Hospital, Memphis, Tennessee, USA., Abdel-Wahab O; Memorial Sloan Kettering Cancer Center, New York, New York, USA., Lei H; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Dou Y; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Guzman M; Weill Cornell Medicine, New York, New York, USA., Peterson L; Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Gruber T; Saint Jude Children's Hospital, Memphis, Tennessee, USA., Choi S; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Sun D; College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA., Ren P; Wellspring Biosciences, Inc., San Diego, California, USA.; Kura Oncology, Inc., San Diego, California, USA., Li LS; Wellspring Biosciences, Inc., San Diego, California, USA., Liu Y; Wellspring Biosciences, Inc., San Diego, California, USA., Burrows F; Kura Oncology, Inc., San Diego, California, USA., Maillard I; Life Sciences Institute and.; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Cierpicki T; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Grembecka J; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2020 Feb 03; Vol. 130 (2), pp. 981-997.