Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Linhai Zhong"'
Autor:
Liyuan Mao, Yan-yan Zhan, Bin Wu, Qiang Yu, Liang Xu, Xiaoting Hong, Linhai Zhong, Panying Mi, Li Xiao, Xinquan Wang, Hanwei Cao, Wenqing Zhang, Binbin Chen, Jingzhou Xiang, Kunrong Mei, Ravi Radhakrishnan, Wei Guo, Tianhui Hu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Elevated expression of ULK1 is known to be inversely correlated with breast cancer metastasis. Here, the authors report Exo70 as a substrate of ULK1 that suppresses cancer metastasis, and show that ERK1/2 mediated phosphorylation of Exo70 leads to op
Externí odkaz:
https://doaj.org/article/7a8d91e583c5427ba8f9a268e2cf0b5b
Autor:
Xiaoting Hong, Linhai Zhong, Yurou Xie, Kaifeng Zheng, Jinglong Pang, Yesen Li, Yifan Yang, Xiaolin Xu, Panying Mi, Hanwei Cao, Wenqing Zhang, Tianhui Hu, Gang Song, Daxuan Wang, Yan-yan Zhan
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The Warburg effect is a peculiar feature of cancer’s metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue. Matrine is an alkaloid extracted from the herb root of a traditional Chinese medicine
Externí odkaz:
https://doaj.org/article/ece995cda1a645419194407b80d39d78
Autor:
Yujie Zhao, Xiaoting Hong, Xiong Chen, Chun Hu, Weihong Lu, Baoying Xie, Linhai Zhong, Wenqing Zhang, Hanwei Cao, Binbin Chen, Qian Liu, Yanyan Zhan, Li Xiao, Tianhui Hu
Publikováno v:
Cancers, Vol 13, Iss 14, p 3467 (2021)
Whilst researches elucidating a diversity of intracellular mechanisms, platinum-resistant epithelial ovarian cancer (EOC) remains a major challenge in the treatment of ovarian cancer. Here we report that Exo70, a key subunit of the exocyst complex, c
Externí odkaz:
https://doaj.org/article/ccd3f92dd7144a36b3733934e4da2463
Autor:
Jinying Shen, Yujie Zhao, Linhai Zhong, Tianhui Hu, Xiong Chen, Xiaolin Xu, Daxuan Wang, Yan-yan Zhan, Xiaoting Hong, Hanwei Cao, Yitong Zhou, Jianben Wu, Ying Lin, Wenqing Zhang, Jihuan Hou
Publikováno v:
Cancer Research. 81:5904-5918
Invasive mucinous lung adenocarcinoma (IMA) is a subtype of lung adenocarcinoma with a strong invasive ability. IMA frequently carries "undruggable" KRAS mutations, highlighting the need for new molecular targets and therapies. Nuclear receptor HNF4
Autor:
Tianhui Hu, Yandong Zhang, Beibei Xu, Hanwei Cao, Wenqing Zhang, Yan-yan Zhan, Hao Zhang, Yuan Tian, Xunjin Jiang, Ning Xu, Xiaoting Hong, Jing Xiong, Jun Lan, Xinquan Wang, Linhai Zhong
Publikováno v:
Journal of Medicinal Chemistry. 63:5841-5855
We reported recently that berberine (Ber), a traditional oriental medicine to treat gastroenteritis, binds and activates retinoid X receptor α (RXRα) for suppressing the growth of colon cancer cells. Here, we extended our studies based on the bindi
Autor:
Linhai Zhong, Baoying Xie, Tianhui Hu, Xiaoting Hong, Wenqing Zhang, Binbin Chen, Yan-yan Zhan, Weihong Lu, Xiong Chen, Yujie Zhao, Hanwei Cao, Chun Hu, Li Xiao, Qian Liu
Publikováno v:
Cancers, Vol 13, Iss 3467, p 3467 (2021)
Cancers
Volume 13
Issue 14
Cancers
Volume 13
Issue 14
Simple Summary Innate and acquired platinum resistance are the leading causes of epithelial ovarian cancer (EOC) mortality. However, the mechanisms remain elusive. Here we found that Exo70, a key subunit of the exocyst, is upregulated in EOC and prom
Autor:
Ke Gong, Qingqi Hong, Huiwen Wu, Fen Wang, Linhai Zhong, Lingjia Shen, Piao Xu, Wenqing Zhang, Hanwei Cao, Yan-yan Zhan, Tianhui Hu, Xiaoting Hong
Publikováno v:
Cancer letters. 531
In vivo tumor growth is characterized by a necrotic core generated by oxygen and nutrients gradients, which is replicated by in vitro three-dimensional (3D) tumor spheroids but not traditional two-dimensional cell monolayers. Gap junctions provide di
Autor:
Beibei, Xu, Xunjin, Jiang, Jing, Xiong, Jun, Lan, Yuan, Tian, Linhai, Zhong, Xinquan, Wang, Ning, Xu, Hanwei, Cao, Wenqing, Zhang, Hao, Zhang, Xiaoting, Hong, Yan-Yan, Zhan, Yandong, Zhang, Tianhui, Hu
Publikováno v:
Journal of medicinal chemistry. 63(11)
We reported recently that
Autor:
Xinquan Wang, Wei Guo, Xiaoting Hong, Bin Wu, Li Xiao, Ravi Radhakrishnan, Kunrong Mei, Qiang Yu, Linhai Zhong, Jingzhou Xiang, Yan-yan Zhan, Panying Mi, Liang Xu, Cao Hanwei, Binbin Chen, Wenqing Zhang, Liyuan Mao, Tianhui Hu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through di