Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Linh Vong"'
Autor:
Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V Khera, John Danesh, Philippe Frossard, Danish Saleheen
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010093 (2022)
Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. Previous stu
Externí odkaz:
https://doaj.org/article/9c0268137d414840bbba8d1073dcccdf
Autor:
Martina Krenzer, Christelle Anaclet, Ramalingam Vetrivelan, Nishang Wang, Linh Vong, Bradford B Lowell, Patrick M Fuller, Jun Lu
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e24998 (2011)
Previous work has suggested, but not demonstrated directly, a critical role for both glutamatergic and GABAergic neurons of the pontine tegmentum in the regulation of rapid eye movement (REM) sleep.To determine the in vivo roles of these fast-acting
Externí odkaz:
https://doaj.org/article/ece727d1073f445d929082b6cbbdc20e
Autor:
Syed Zahed Rasheed, Sean Richards, Asif Rasheed, Nabi Shah, Anastasia Gurinovich, Treeve Currie, Shahid Abbas, Shari L. Caplan, Subhan Saeed, Shareef Khalid, Amit Khera, John Dominy, Linh Vong, Allan Gurtan, Sekar Kathiresan, Daniel Denning, Fazal-ur-Rehman Memon, Lindsey Lamarche, Philippe M. Frossard, Anjum Jalal, John Danesh, Raffat Sultana, Shahid Hameed, M. Ishaq, Danish Saleheen, Imran Saleem, Diana Shpektor
Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. Previous stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3b5cdeab427812b92c0c210a03d9b26
https://doi.org/10.1101/2021.10.21.21264378
https://doi.org/10.1101/2021.10.21.21264378
Autor:
Iain M. Wallace, Hyun-Hee Cho, Pramod Pandey, Soo-Hee Park, Allison Fedolak, Dechristopher Brian Addison, Christopher Hogan, Olga Rozhitskaya, Derek Bamford, Liansheng Su, Toshiyuki Honda, Rohit Duvadie, Linh Vong, Elizabeth Tomlinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:991-994
The relaxin family peptide receptors have been implicated in numerous physiological processes including energy homeostasis, cardiac function, wound healing, and reproductive function. Two family members, RXFP3 and RXFP4, are class A GPCRs with endoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418b6fe5324da9d6735f1f588262d09c
https://doi.org/10.1016/j.bmcl.2019.02.013
https://doi.org/10.1016/j.bmcl.2019.02.013
Autor:
Xiangyu Ren, Yun Wang, Yangyang Chen, Yan Zhang, Tianwen Huang, Olivier Britz, Qiufu Ma, Linh Vong, Bo Duan, Martyn Goulding, Lidia Garcia-Campmany, Longzhen Cheng, Bradford B. Lowell
Publikováno v:
Nature neuroscience
Mechanical hypersensitivity is a debilitating symptom associated with millions of chronic pain patients. It exists in distinct forms, including brush-evoked dynamic and filament-evoked punctate. Here we report that dynamic mechanical hypersensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4874ca4a3fcfccd6228017cfaad68629
http://europepmc.org/articles/PMC5470641
http://europepmc.org/articles/PMC5470641
Akademický článek
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Autor:
David P. Olson, Bhavik P. Shah, Chianping Ye, Joel K. Elmquist, Zongfang Yang, Michael J. Krashes, Patrick M. Fuller, Shuichi Koda, Linh Vong, Bradford B. Lowell
Publikováno v:
Proceedings of the National Academy of Sciences. 111:13193-13198
Activation of melanocortin-4 receptors (MC4Rs) restrains feeding and prevents obesity; however, the identity, location, and axonal projections of the neurons bearing MC4Rs that control feeding remain unknown. Reexpression of MC4Rs on single-minded 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634f608e909ce9d842c686a33253ad69
https://doi.org/10.1073/pnas.1407843111
https://doi.org/10.1073/pnas.1407843111
Autor:
Linh Vong, Bhavik P. Shah, David P. Olson, Joseph C. Madara, Stephen D. Liberles, David E. Strochlic, Bradford B. Lowell, Hongjuan Pei, Michael J. Krashes, Naoshige Uchida, Mitsuko Watabe-Uchida, Alastair S. Garfield
Publikováno v:
Nature
Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the control of hunger. They are activated by caloric defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede93c04f28832e4ef986ea43467921a
http://europepmc.org/articles/PMC3955843
http://europepmc.org/articles/PMC3955843
Publikováno v:
The Journal of Neuroscience. 33:870-882
VGLUT3-expressing unmyelinated low-threshold mechanoreceptors (C-LTMRs) are proposed to mediate pleasant touch and/or pain, but the molecular programs controlling C-LTMR development are unknown. Here, we performed genetic fate mapping, showing that V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11472aeac763bef218a7be0eb5171b5
https://doi.org/10.1523/jneurosci.3942-12.2013
https://doi.org/10.1523/jneurosci.3942-12.2013
Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons
Autor:
Eric D. Berglund, Louise E. Harris, Nina Balthasar, Linh Vong, Bradford B. Lowell, Kevin W. Williams, Joel K. Elmquist, Jong Woo Sohn, Tiemin Liu
Publikováno v:
Sohn, J-W, Harris, L E, Berglund, E D, Liu, T, Vong, L, Lowell, B B, Balthasar, N, Williams, K W & Elmquist, J K 2013, ' Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons ', Cell, vol. 152, no. 3, pp. 612-619 . https://doi.org/10.1016/j.cell.2012.12.022
SummaryMelanocortin 4 receptors (MC4Rs) in the central nervous system are key regulators of energy and glucose homeostasis. Notably, obese patients with MC4R mutations are hyperinsulinemic and resistant to obesity-induced hypertension. Although these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69556417853c050ff21814eb70dcdef
https://doi.org/10.1016/j.cell.2012.12.022
https://doi.org/10.1016/j.cell.2012.12.022