Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Linh Mach"'
Autor:
Navid Madani, Amy M. Princiotto, Linh Mach, Shilei Ding, Jérémie Prevost, Jonathan Richard, Bhavna Hora, Laura Sutherland, Connie A. Zhao, Brandon P. Conn, Todd Bradley, M. Anthony Moody, Bruno Melillo, Andrés Finzi, Barton F. Haynes, Amos B. Smith III, Sampa Santra, Joseph Sodroski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human
Externí odkaz:
https://doaj.org/article/ac213354426e4f05910a41474b6a0b00
Autor:
Andrés Finzi, Amos B. Smith, Linh Mach, Brandon P. Conn, Jonathan Richard, Laura L. Sutherland, Navid Madani, Bruno Melillo, Jérémie Prévost, M. Anthony Moody, Amy M. Princiotto, Todd Bradley, Sampa Santra, Bhavna Hora, Barton F. Haynes, Connie Zhao, Shilei Ding, Joseph Sodroski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The envelope glycoprotein (Env) trimer ((gp120/gp41)3) mediates human immunodeficiency virus (HIV-1) entry into cells. The “closed,” antibody-resistant Env trimer is driven to more open conformations by binding the host receptor, CD4. Broadly neu
Autor:
Linh Mach, Bette T. Korber, Robert Parks, Hua-Xin Liao, Steven G. Reed, Barton F. Haynes, Amanda Eaton, Georgia D. Tomaras, Richard M. Scearce, Nelson L. Michael, Xiaoying Shen, James F. Theis, Galit Alter, M. Anthony Moody, Kristina K. Peachman, Srivamshi Pittala, Shiu Lok Hu, Guido Ferrari, David C. Montefiori, Harikrishnan Balachandran, Mangala Rao, Sanjay Phogat, Derrick Goodman, Thomas B. Kepler, Laura L. Sutherland, Margaret E. Ackerman, Todd Bradley, Joshua A. Weiner, Kevin O. Saunders, Justin Pollara, Sampa Santra, Jim Tartaglia, Nathan Vandergrift, Abraham Pinter, Todd J. Suscovich, Chris Bailey-Kellogg
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
The RV144 Thai trial HIV-1 vaccine of recombinant poxvirus (ALVAC) and recombinant HIV-1 gp120 subtype B/subtype E (B/E) proteins demonstrated 31% vaccine efficacy. Here we design an ALVAC/Pentavalent B/E/E/E/E vaccine to increase the diversity of gp
Autor:
Hua-Xin Liao, Guido Ferrari, Punnee Pitisuttithum, Thomas N. Denny, Justin Pollara, Nicole L. Yates, Georgia D. Tomaras, Florian Hladik, George M. Shaw, Barton F. Haynes, M. Juliana McElrath, Georgeanna Morton, Katharine Westerberg, Tiffany Hensley-McBain, Shi-Mao Xia, Linh Mach, Sampa Santra, Benjamin Mildenberg, Gregory J. Mize, Ranjit Warrier, Rena D. Astronomo, Jaranit Kaewkungwal, Christina Ochsenbauer, Sorachai Nitayapan, Supachai Rerks-Ngarm, Lamar Ballweber-Fleming, Laura L. Sutherland, David C. Montefiori
Publikováno v:
EBioMedicine
HIV-1 infection occurs primarily through mucosal transmission. Application of biologically relevant mucosal models can advance understanding of the functional properties of antibodies that mediate HIV protection, thereby guiding antibody-based vaccin
Autor:
Barton F. Haynes, Giuseppe Pantaleo, Harikrishnan Balachandran, Hua-Xin Liao, Barbara K. Felber, David C. Montefiori, Mariano Esteban, Michael S. Seaman, Sampa Santra, Carmen E. Gómez, Margherita Rosati, Nathan Vandergrift, Kevin O. Saunders, Jim Tartaglia, Michelle A. Lifton, Sanjay Phogat, Beatriz Perdiguero, Robert Parks, George N. Pavlakis, Richard M. Scearce, Elena E. Giorgi, Karen V. Kibler, Krissey E. Lloyd, S. Munir Alam, Bertram L. Jacobs, Linh Mach, Bette T. Korber, Sandrine L. Hulot, Norman L. Letvin, Laura L. Sutherland
Publikováno v:
Journal of Virology. 89:6462-6480
An effective human immunodeficiency virus type 1 (HIV-1) vaccine must induce protective antibody responses, as well as CD4 + and CD8 + T cell responses, that can be effective despite extraordinary diversity of HIV-1. The consensus and mosaic immunoge
Autor:
Hanne Anderson, Matthias Pauthner, Khoa Le, Beatrice H. Hahn, Ranajit Pal, Christie Brinkley, Mark G. Lewis, Joseph Sodroski, Devin Sok, Sampa Santra, Barton F. Haynes, Christy L. Lavine, Burton, Seaman, Mohammed Asmal, Linh Mach, Corinne Luedemann, George M. Shaw, Harikrishnan Balachandran, Thomas N. Denny, Norman L. Letvin
Publikováno v:
Virology. 478:149-152
Autor:
Christy L. Lavine, Sampa Santra, Hanne Anderson, George M. Shaw, Matthias Pauthner, Christie Brinkley, Barton F. Haynes, Khoa Le, Michael S. Seaman, Dennis R. Burton, Thomas N. Denny, Linh Mach, Norman L. Letvin, Joseph Sodroski, Mark G. Lewis, Beatrice H. Hahn, Ranajit Pal, Mohammed Asmal, Harikrishnan Balachandran, Corinne Luedemann, Devin Sok
Publikováno v:
Virology. 475:37-45
Simian-human immunodeficiency viruses (SHIVs) that mirror natural transmitted/founder (T/F) viruses in man are needed for evaluation of HIV-1 vaccine candidates in nonhuman primates. Currently available SHIVs contain HIV-1 env genes from chronically-
Autor:
S. Munir Alam, Guido Ferrari, Thomas N. Denny, Stephen D. Schmidt, Mark K. Louder, Brandy M. Ward, Norman L. Letvin, Hugh C. Welles, Rosemarie D. Mason, Ling Shen, Celia C. LaBranche, Raphael Gottardo, Kathryn E. Foulds, Kelly E. Seaton, Martha Nason, Robert T. Bailer, Robert A. Seder, Will Fischer, Linh Mach, Mario Roederer, John R. Mascola, Georgia D. Tomaras, Bette T. Korber, Srinivas S. Rao, John Paul Todd, Brandon F. Keele, Adam P. Buzby, Gary J. Nabel, Richard A. Koup, Zhi-Yong Yang, David C. Montefiori, Wenjuan Gu
Publikováno v:
Nature
A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a nonhuman primate challenge model with simian immunodeficiency virus (SIV). We sho
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Autor:
Eric J. Arts, Srinivas S. Rao, Brennan S. Dirk, Colin Venner, Yong Gao, Mohammed Asmal, Linh Mach, Gabrielle Nickel, Meijuan Tian, Corinne Luedemann, Adam P. Buzby, Jimmy D. Dikeakos, Harikrishnan Balachandran, Norman L. Letvin, Sophie Lane
Publikováno v:
Virology. 499
For studies on vaccines and therapies for HIV disease, SIV-HIV chimeric viruses harboring the HIV-1 env gene (SHIVenv) remain the best virus in non-human primate models. However, there are still very few SHIVenv viruses that can cause AIDS in non-CD8