Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Lingzhi Qu"'
Autor:
Qianmeng Lin, Shuyan Dai, Lingzhi Qu, Hang Lin, Ming Guo, Hudie Wei, Yongheng Chen, Xiaojuan Chen
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Acquired drug resistance poses a challenge for single-target FGFR inhibitors, leading to the development of dual- or multi-target FGFR inhibitors. Sulfatinib is a multi-target kinase inhibitor for treating neuroendocrine tumors, selectively
Externí odkaz:
https://doaj.org/article/dcafca7f8809436ea954478d3121cab2
Autor:
Hudie Wei, Haolan Wang, Genxin Wang, Lingzhi Qu, Longying Jiang, Shuyan Dai, Xiaojuan Chen, Ye Zhang, Zhuchu Chen, Youjun Li, Ming Guo, Yongheng Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53 triggers transcription-independent apoptosis through direct interactions with BCL-2 fa
Externí odkaz:
https://doaj.org/article/db48de5db5fe4d37941c8b75ef220bd1
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-15 (2023)
Abstract Background Necroptosis has been reported to play a critical role in occurrence and progression of cancer. The dysregulation of long non-coding RNAs (lncRNAs) is associated with the progression and metastasis of clear cell renal cell carcinom
Externí odkaz:
https://doaj.org/article/d75e33f03c0b4cac9bc152686d00e988
Autor:
Lingzhi Qu, Hang Lin, Shuyan Dai, Ming Guo, Xiaojuan Chen, Longying Jiang, Huajun Zhang, Maoyu Li, Xunjun Liang, Zhuchu Chen, Hudie Wei, Yongheng Chen
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5712-5718 (2023)
c-Met has been an attractive target of prognostic and therapeutic studies in various cancers. TPX-0022 is a macrocyclic inhibitor of c-Met, c-Src and CSF1R kinases and is currently in phase I/II clinical trials in patients with advanced solid tumors
Externí odkaz:
https://doaj.org/article/ce007b844e0342e383a6ce6b5925beef
Autor:
Shuyan Dai, Lingzhi Qu, Jun Li, Ye Zhang, Longying Jiang, Hudie Wei, Ming Guo, Xiaojuan Chen, Yongheng Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The aryl hydrocarbon receptor (AHR) plays important roles in regulating xenobiotic metabolism, cellular differentiation, and immunity. Here, the authors present multiple crystal structures of the Drosophila AHR PAS-B domain, providing insights into t
Externí odkaz:
https://doaj.org/article/d6d72f2036974b189ce82388bd9cf661
Autor:
Qianmeng Lin, Xiaojuan Chen, Lingzhi Qu, Ming Guo, Hudie Wei, Shuyan Dai, Longying Jiang, Yongheng Chen
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-7 (2022)
Pemigatinib is an FDA-approved drug for the treatment of cholangiocarcinoma, but while it is known to target fibroblast growth factor receptors, its mechanism of action is still not fully understood. Here, biochemical and structural analyses reveal t
Externí odkaz:
https://doaj.org/article/1e50b41b7d064d1c99cb346371dc4f80
Autor:
Xiaojuan Chen, Huiliang Li, Qianmeng Lin, Shuyan Dai, Sitong Yue, Lingzhi Qu, Maoyu Li, Ming Guo, Hudie Wei, Jun Li, Longying Jiang, Guangyu Xu, Yongheng Chen
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-7 (2022)
Fibroblast growth factor receptor 4 (FGFR4) is a promising target for the treatment of hepatocellular carcinoma, but current FGFR4 covalent inhibitors target only one of the two cysteine residues (Cys477 or Cys552) that provide FGFR4-specificity. Her
Externí odkaz:
https://doaj.org/article/8f8500b212114b63a4dc6a6db03f200d
Autor:
Lingzhi Qu, Xiaojuan Chen, Hudie Wei, Ming Guo, Shuyan Dai, Longying Jiang, Jun Li, Sitong Yue, Zhuchu Chen, Yongheng Chen
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-9 (2022)
The human fibroblast growth factor receptors (FGFRs) are attractive targets for cancer therapy, but the structural basis for kinase targeting and gatekeeper mutations of covalent FGFR inhibitors are not fully understood. Here the authors report and d
Externí odkaz:
https://doaj.org/article/1de327615f9347d2b61e482722b6126b
Publikováno v:
Applied Sciences, Vol 13, Iss 15, p 8850 (2023)
This study investigates the feasibility of identifying the axial position of circumferential defects in laminated pipeline structures based on damage indices. Wavelet packet decomposition is combined with damage indices, and the effects of dual defec
Externí odkaz:
https://doaj.org/article/d832d21caa364f00aec043b683c7a893
Autor:
Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang, Yongheng Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The structure of human tumor suppressor p53 in complex with the antiapoptotic protein BCL-xL reveals the basis of the p53–BCL-xL interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.
Externí odkaz:
https://doaj.org/article/eee86fb8caf449e7a93cc5a90e776ac6