Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lingyun Rui"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/74a59eff2bcf46339d1914d51aeab207
Autor:
Yelena Kovtun, Gregory E. Jones, Sharlene Adams, Lauren Harvey, Charlene A. Audette, Alan Wilhelm, Chen Bai, Lingyun Rui, Rassol Laleau, Fenghua Liu, Olga Ab, Yulius Setiady, Nicholas C. Yoder, Victor S. Goldmacher, Ravi V.J. Chari, Jan Pinkas, Thomas Chittenden
Publikováno v:
Blood Advances, Vol 2, Iss 8, Pp 848-858 (2018)
Abstract: The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated with unacceptable toxicities, including severe infections due to profound myelosuppr
Externí odkaz:
https://doaj.org/article/221c467857af4029b2863119ee489741
Autor:
Lingyun Rui, Jing Xu, Yao-Te Hsieh, Li Yue-Sheng, Jonathan Carnino, Sreerupa Challa, Andrea Umana
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundHigh-dose Interleukin-2 is the earliest FDA-approved immunotherapy for metastatic melanoma and renal cell carcinoma. Unfortunately, its application is limited due to its short half-life and severe toxicity at the therapeutic dose. To limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f02049e5b38741b19cf5f872374327d
https://doi.org/10.1136/jitc-2021-sitc2021.858
https://doi.org/10.1136/jitc-2021-sitc2021.858
Publikováno v:
Applied and Environmental Microbiology. 71:3995-4003
DNA shuffling and saturation mutagenesis of positions F108, L190, I219, D235, and C248 were used to generate variants of the epoxide hydrolase of Agrobacterium radiobacter AD1 (EchA) with enhanced enantioselectivity and activity for styrene oxide and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5f156b60f593576dc28f819f3653f3
https://doi.org/10.1128/aem.71.7.3995-4003.2005
https://doi.org/10.1128/aem.71.7.3995-4003.2005
Publikováno v:
Journal of Biological Chemistry. 280:506-514
A primary goal of protein engineering is to control catalytic activity. Here we show that through mutagenesis of three active site residues, the catalytic activity of a multicomponent monooxygenase is altered so that it hydroxylates all three positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7ab0c893f3883b102b9f8840b7c70b
https://doi.org/10.1074/jbc.m410320200
https://doi.org/10.1074/jbc.m410320200
Autor:
Thomas A. Keating, Olga Ab, Juliet Costoplus, Jose F. Ponte, Jan Pinkas, Leanne Lanieri, Daniel Tavares, Lingyun Rui, Luke Harris, Laura M. Bartle, Nathan Fishkin, Erin K. Maloney, Ravi V. J. Chari
Publikováno v:
Cancer Research. 76:2967-2967
Site-specific attachment of cell-killing agents to antibodies directed against tumor-associated antigens has continued to be an active area of innovation in the field of ADCs. Most reports focus on homogeneous ADCs that have a DAR (cytotoxic molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5a7c5037d8babdb563c394708757b7d
https://doi.org/10.1158/1538-7445.am2016-2967
https://doi.org/10.1158/1538-7445.am2016-2967
Autor:
Kathleen R. Whiteman, Daniel Tavares, Katie E. Archer, Sonia Connaughton, Rui Wu, Ravi V. J. Chari, Erin K. Maloney, Nathan Fishkin, Michael L. Miller, Erica Hong, Manami Shizuka, Lingyun Rui, Luke Harris, Jan Pinkas, Wayne C. Widdison, Lintao Wang, Xiangyang Xu, Xuan Chen, Lauren Harvey, Juliet Costoplus, Alan Wilhelm, Megan Bogalhas, Thomas A. Keating, Olga Ab
Publikováno v:
Cancer Research. 75:647-647
Site-specific incorporation of cell-killing agents into cancer-targeting antibodies is an active area of innovation in the field of ADCs. We have developed a highly modular site-specific conjugation platform employing N-terminal serine engineered ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3331d2252afe3a094a867a2c6bf3011
https://doi.org/10.1158/1538-7445.am2015-647
https://doi.org/10.1158/1538-7445.am2015-647
Autor:
Lingyun Rui, Luke Harris, Nathan Fishkin, Daniel Tavares, Erin K. Maloney, Olga Ab, Thomas A. Keating, Thomas Chittenden
Publikováno v:
Cancer Research. 75:653-653
Emerging data from the growing number of antibody-drug conjugates (ADCs) in clinical studies reflects the critical contributions from each component of the ADC. The tumor-targeting antibody and the cytotoxic effector molecule are recognized as key el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9e5c2165f51dfb70106e9924f64dfd2
https://doi.org/10.1158/1538-7445.am2015-653
https://doi.org/10.1158/1538-7445.am2015-653
Publikováno v:
Pseudomonas ISBN: 9780387288345
Toluene monooxygenases from pseudomonads are powerful enzymes whose activities have not been fully appreciated. Recently the literature was corrected to show there was no true, predominantly meta-hydroxylating enzyme, and it was discovered that these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c669d2d1a6d9249f599985abd38c64c
https://doi.org/10.1007/0-387-28881-3_8
https://doi.org/10.1007/0-387-28881-3_8
Structural perturbations in cytochrome P450cam (CYP101) induced by the soluble fragment of cytochrome b5, a nonphysiological effector of CYP101, were investigated by NMR spectroscopy and compared with the perturbations induced by the physiological re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e2b281a5110a04cf499c2703791e6b
https://europepmc.org/articles/PMC2265421/
https://europepmc.org/articles/PMC2265421/