Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Lingyu Shi"'
Autor:
Chao Wang, Yujing Zhang, Shanbo Yang, Lingyu Shi, Rong Rong, Tingting Zhang, Yudong Wu, Dongming Xing
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractA new series of 1H-pyrrolo[3,2-c]pyridine derivatives were designed and synthesised as colchicine-binding site inhibitors. Preliminary biological evaluations showed that most of the target compounds displayed moderate to excellent antitumor a
Externí odkaz:
https://doaj.org/article/f64cf30fe3d14e0bac180712344b0f19
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractA series of cis-restricted 3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines as novel tubulin polymerisation inhibitors was designed based on molecular docking. Compound 9p, exhibited potent antiproliferative activity against HeLa, MCF-7, and A549 c
Externí odkaz:
https://doaj.org/article/20346a9d73e8457f95d03cd1b57f851a
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
In this work, a series of new diarylpyrimidine derivatives as microtubule destabilizers were designed, synthesized, and evaluated for anticancer activities. Based on restriction configuration strategy, we introduced the pyrimidine moiety containing t
Externí odkaz:
https://doaj.org/article/4ac1e4ba7c8f4174af36c6238eba83e3
Autor:
Dehong Mu, Li Zhou, Lingyu Shi, Ting Liu, Ying Guo, Hao Chen, Hongping Luo, Junhao Ma, Hui Zhang, Peizheng Xiong, Li Tian
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Allergic rhinitis (AR) remains a major health problem worldwide. Compared with traditional oral drugs, nasal administration avoids first-pass metabolism and achieve faster and more effective efficacy. In this study, we used the ion crosslink
Externí odkaz:
https://doaj.org/article/3f860a8f67de4bd39e59b9d3da594a5e
Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Wolfram Syndrome (WS) is a fatal human inherited disease with symptoms of diabetes, vision decreasing, and neurodegeneration caused by mutations in the endoplasmic reticulum (ER)-resident protein WFS1. WFS1 has been reported to play an impor
Externí odkaz:
https://doaj.org/article/1024e6b6df514775874648ea03b90eda
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1667-1693 (2022)
Proteolysis-targeting chimaeras (PROTACs) have been developed to be an emerging technology for targeted protein degradation and attracted the favour of academic institutions, large pharmaceutical enterprises, and biotechnology companies. The mechanis
Externí odkaz:
https://doaj.org/article/8f1ddd2b31564c63b8a4c2e627a6fa49
Autor:
Shanbo Yang, Chao Wang, Lingyu Shi, Jing Chang, Yujing Zhang, Jingsen Meng, Wenjing Liu, Jun Zeng, Renshuai Zhang, Yingchun Shao, Dongming Xing
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2755-2764 (2022)
A set of novel diarylpyridines as anti-tubulin agents were designed, synthesised using a rigid pyridine as a linker to fix the cis-orientation of ring-A and ring-B. All of the target compounds were evaluated for their in vitro antiproliferative activ
Externí odkaz:
https://doaj.org/article/54bb24125c124900bb988da63e194a86
Autor:
Chao Wang, Yujing Zhang, Lingyu Shi, Shanbo Yang, Jing Chang, Yingjie Zhong, Qian Li, Dongming Xing
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1437-1453 (2022)
Proteolytic targeting chimaeras (PROTACs) have been developed as an effective technology for targeted protein degradation. PROTACs are heterobifunctional molecules that can trigger the polyubiquitination of proteins of interest (POIs) by recruiting t
Externí odkaz:
https://doaj.org/article/1bb81f185be94960847f7174c8cefb8e
Autor:
Chao Wang, Lingyu Shi, Shanbo Yang, Jing Chang, Wenjing Liu, Jun Zeng, Jingsen Meng, Renshuai Zhang, Dongming Xing
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Cancer threatens human health and life. Therefore, it is particularly important to develop safe and effective antitumor drugs. Microtubules, the main component of cytoskeleton, play an important role in maintaining cell morphology, mitosis, and signa
Externí odkaz:
https://doaj.org/article/2462a0cc022647e5bca15fc0465da036
Autor:
Jing Chang, Chao Wang, Shanbo Yang, Lingyu Shi, Yujing Zhang, Wenjing Liu, Jingsen Meng, Jun Zeng, Renshuai Zhang, Ning Liu, Dongming Xing
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 11, Pp 104253- (2022)
A new series of novel diarylpyrazole derivatives as microtubule destabilizers were synthesized and evaluated for the anti-proliferative activities. Anti-proliferative assays were performed on the human cervix adenocarcinoma cell line (HeLa) and human
Externí odkaz:
https://doaj.org/article/e1ef45760e5b40bbb7092f5b6bf4f7e6