Výsledky vyhledávání

Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes

Autor: David M. Habiel, Sina A. Gharib, Ying Huang, Nan Deng, Peter Chen, Cory M. Hogaboam, William C. Parks, Dianhua Jiang, Lingyin Ge, Rena Brauer, Zhenqui Liu, Tanyalak Parimon, Ting Xie, Timothy P. Birkland, Saundra Y. Schlesinger

Publikováno v: The American Journal of Pathology. 188:1094-1103

Syndecan-1 is a transmembrane proteoglycan expressed prominently by lung epithelium and has pleiotropic functions such as regulating cell migration, proliferation, and survival. Loss of syndecan-1 expression by lung cancer cells is associated with hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35f56727aecb14a10cdade076fd0ca1
https://doi.org/10.1016/j.ajpath.2017.12.009

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Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles

Publikováno v: JCI insight, vol 5, iss 17

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal lung disease. A maladaptive epithelium due to chronic injury is a prominent feature and contributor to pathogenic cellular communication in IPF. Recent data highlight the concept of a "reprog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9eab71a0cdb2e56dc8288df11137c0e
https://pubmed.ncbi.nlm.nih.gov/31393853

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Syndecan-1 Attenuates Lung Injury during Influenza Infection by Potentiating c-Met Signaling to Suppress Epithelial Apoptosis

Autor: Vivian Lee, Lingyin Ge, Saundra Y. Schlesinger, Peter Chen, Timothy P. Birkland, Bonnie L. McKinney, Rena Brauer, Ying Huang, John K. McGuire, William C. Parks, Tanyalak Parimon

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 194:333-344

Syndecan-1 is a cell surface heparan sulfate proteoglycan primarily expressed in the lung epithelium. Because the influenza virus is tropic to the airway epithelium, we investigated the role of syndecan-1 in influenza infection.To determine the mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795083b4c4c5c12046a46ce35801f793
https://doi.org/10.1164/rccm.201509-1878oc

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TIMP-1 Promotes the Immune Response in Influenza Induced Acute Lung Injury

Autor: Suzanne L. Cassel, Rena Brauer, Fayyaz S. Sutterwala, Jenieke R. Allen, Ying Huang, Peter Chen, Tanyalak Parimon, Lingyin Ge

INTRODUCTION: Influenza infects millions of people each year causing respiratory distress and death in severe cases. On average, 200,000 people annually are hospitalized in the United States for influenza related complications. Tissue inhibitor of me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f15dbbda407a120642ab00f4420d02
https://europepmc.org/articles/PMC6283619/

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Circulating complexes of the vitamin D binding protein with G-actin induce lung inflammation by targeting endothelial cells

Autor: Glenda Trujillo, Lingyin Ge, Edmund J. Miller, Richard R. Kew

Publikováno v: Immunobiology. 219:198-207

This study investigated the actin scavenger function of the vitamin D binding protein (DBP) in vivo using DBP null (−/−) mice. Intravenous injection of G-actin into wild-type (DBP+/+) and DBP−/− mice showed that contrary to expectations, DBP+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e0a0386121427d012b10f54573d2ef
https://doi.org/10.1016/j.imbio.2013.10.001

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Cofactor regulation of C5a chemotactic activity in physiological fluids. Requirement for the vitamin D binding protein, thrombospondin-1 and its receptors

Autor: Richard R. Kew, Berhane Ghebrehiwet, Jianhua Zhang, David M. Habiel, Glenda Trujillo, Mahalakshmi Ramadass, Lingyin Ge

Publikováno v: Molecular Immunology. 49:495-503

Factors in physiological fluids that regulate the chemotactic activity of complement activation peptides C5a and C5a des Arg are not well understood. The vitamin D binding protein (DBP) has been shown to significantly enhance chemotaxis to C5a/C5a de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9c2c10a2a7921c04a024f6ffea466a
https://doi.org/10.1016/j.molimm.2011.09.024

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Acute Cellular Rejection Elicits Distinct MicroRNA Signatures in Airway Epithelium of Lung Transplant Patients

Autor: Peter Chen, Jeffery D. Edelman, Lingyin Ge, Sina A. Gharib

Publikováno v: Transplantation Direct

Supplemental digital content is available in the text.
Acute cellular rejection (ACR) is a common complication in lung transplantation and associated with increased risk of chronic allograft dysfunction. MicroRNAs are critical controllers of cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13a2d3ef92f722769231a77a540487e
http://europepmc.org/articles/PMC4914138

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Sustained activation of toll-like receptor 9 induces an invasive phenotype in lung fibroblasts: possible implications in idiopathic pulmonary fibrosis

Autor: Varvara, Kirillov, Jonathan T, Siler, Mahalakshmi, Ramadass, Lingyin, Ge, James, Davis, Geraldine, Grant, Steven D, Nathan, Gabor, Jarai, Glenda, Trujillo

Publikováno v: The American journal of pathology. 185(4)

Idiopathic pulmonary fibrosis (IPF) is characterized by excessive scarring of the lung parenchyma, resulting in a steady decline of lung function and ultimately respiratory failure. The disease course of IPF is extremely variable, with some patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4108594dd3352dc3aa798fe07e9fbc84
https://pubmed.ncbi.nlm.nih.gov/25660181

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