Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lingxing Zheng"'
Autor:
Melissa Tully, Jonathan Tang, Lingxing Zheng, Glen Acosta, Ran Tian, Lee Hayward, Nicholas Race, David Mattson, Riyi Shi
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Demyelination and axonal injury are the key pathological processes in multiple sclerosis (MS), driven by inflammation and oxidative stress. Acrolein, a byproduct and instigator of oxidative stress, has been demonstrated as a neurotoxin in experimenta
Externí odkaz:
https://doaj.org/article/3040d13f0f5940bc87d39afd7d5196dd
Autor:
Zhe Chen, Breanne Butler, Lingxing Zheng, Robyn R. McCain, Peng Cao, Glen Acosta, Jonathan Tang, Jonghyuck Park, Wenpeng Zhang, Zheng Ouyang, Riyi Shi, Sasha Vega-Alvarez
Publikováno v:
Journal of Neurochemistry. 138:328-338
Currently there are no effective therapies available for the excruciating neuropathic pain that develops after spinal cord injuries (SCI). As such, a great deal of effort is being put into the investigation of novel therapeutic targets that can allev
Autor:
Riyi Shi, Sasha Vega-Alvarez, Lingxing Zheng, Glen Acosta, Peng Cao, Breanne Muratori, Zhe Chen, Jonghyuck Park
Publikováno v:
Journal of Neurochemistry. 135:987-997
Acrolein, an endogenous aldehyde, has been shown to be involved in sensory hypersensitivity after rat spinal cord injury (SCI), for which the pathogenesis is unclear. Acrolein can directly activate a pro-algesic transient receptor protein ankyrin 1 (
Publikováno v:
Neuroscience Bulletin. 30:1017-1024
Cigarette smoke is an important environmental factor associated with a wide array of public health concerns. Acrolein, a component of tobacco smoke and a known toxin to various cell types, may be a key pathological factor mediating the adverse effect
Publikováno v:
Expert Review of Neurotherapeutics. 14:679-685
Oxidative stress has been implicated as a major pathological process underlying CNS disease and trauma. More specifically, acrolein, an unsaturated aldehyde, produced by way of lipid peroxidation, has been shown to play a crucial role in initiating a
Autor:
Abeje Ambaw, Riyi Shi, Glen Acosta, Lingxing Zheng, Mitali A. Tambe, Alan Truong, Amber L. Pond, Seth A. Herr, Fang Liu, Jean-Christophe Rochet, Scott A. Hubers, Katherine E. Strathearn, Elwood K. Walls, Jonathan Tang
Publikováno v:
Molecular and cellular neurosciences. 88
Growing evidence suggests that oxidative stress plays a critical role in neuronal destruction characteristic of Parkinson's disease (PD). However, the molecular mechanisms of oxidative stress-mediated dopaminergic cell death are far from clear. In th
Autor:
Lingxing Zheng, Amber L. Pond, Jonghyuck Park, Riyi Shi, Andrew Marquis, Sasha Vega-Alvarez, Michael K. Walls, Brad Duerstock, He Wang, Zheng Ouyang
Publikováno v:
Journal of Neurochemistry. 129:339-349
Acrolein, an α,β-unsaturated aldehyde and a reactive product of lipid peroxidation, has been suggested as a key factor in neural post-traumatic secondary injury in spinal cord injury (SCI), mainly based on in vitro and ex vivo evidence. Here, we de
Autor:
R. Graham Cooks, Chien-Hsun Chen, Ziqing Lin, Lingxing Zheng, Riyi Shi, Zheng Ouyang, Sandilya V. B. Garimella
Publikováno v:
Analytical Chemistry. 85:11843-11850
A sampling probe based on ambient desorption ionization was designed for in vivo chemical analysis by mass spectrometry in surgical and endoscopic procedures. Sampling ionization of analytes directly from tissue was achieved by sealing the sampling t
Autor:
Jonghyuck Park, Michael K. Walls, Lingxing Zheng, Michael R. Due, Fletcher A. White, Riyi Shi, Yohance M. Allette
Publikováno v:
Journal of Neurochemistry. 128:776-786
Growing evidence suggests that oxidative stress, as associated with spinal cord injury (SCI), may play a critical role in both neuroinflammation and neuropathic pain conditions. The production of the endogenous aldehyde acrolein, following lipid pero
Autor:
Bruce A. Cooper, Jonghyuck Park, Amber Jannasch, Lingxing Zheng, Melissa Tully, Michael K. Walls, Riyi Shi
Publikováno v:
Journal of Neurotrauma. 30:1334-1341
Acrolein has been suggested to be involved in a variety of pathological conditions. The monitoring of acrolein is of significant importance in delineating the pathogenesis of various diseases. Aimed at overcoming the reactivity and volatility of acro