Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds

Autor: Eike-Christian Wamhoff, Larance Ronsard, Jared Feldman, Grant A. Knappe, Blake M. Hauser, Anna Romanov, James Brett Case, Shilpa Sanapala, Evan C. Lam, Kerri J. St. Denis, Julie Boucau, Amy K. Barczak, Alejandro B. Balazs, Michael S. Diamond, Aaron G. Schmidt, Daniel Lingwood, Mark Bathe

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display. However, P-VLPs are thymus-dependent antigens that are themselves immunogenic and

Externí odkaz: https://doaj.org/article/a903d94958bc48e7ac6e79ace0aa2f9a

Antibody-mediated NK cell activation as a correlate of immunity against influenza infection

Autor: Carolyn M. Boudreau, John S. Burke, Ashraf S. Yousif, Maya Sangesland, Sandra Jastrzebski, Chris Verschoor, George Kuchel, Daniel Lingwood, Harry Kleanthous, Iris De Bruijn, Victoria Landolfi, Saranya Sridhar, Galit Alter

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Abstract Antibodies play a critical role in protection against influenza; yet titers and viral neutralization represent incomplete correlates of immunity. Instead, the ability of antibodies to leverage the antiviral power of the innate immune system

Externí odkaz: https://doaj.org/article/60ac7790d439465f88919dbc719bf04c

Rotating disks and cones a centennial of von Kármán’s 1921 paper

Autor: Kentaro KATO, Rebecca J. LINGWOOD, P. Henrik ALFREDSSON

Publikováno v: Journal of Fluid Science and Technology, Vol 18, Iss 1, Pp JFST0003-JFST0003 (2023)

It is now more than 100 years since the work of von Kármán (1921) on the boundary-layer flow over a rotating disk was published in the first volume of Zeitschrift für Angewandte Mathematik und Mechanik (ZAMM, Vol. 1(4), pp 233-252). Recently, ther

Externí odkaz: https://doaj.org/article/f10dd44c978d4ce19b412da9c4246ea1

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Updated baseline for a staged Compact Linear Collider

Autor: CLIC, The, collaborations, CLICdp, Boland, M. J., Felzmann, U., Giansiracusa, P. J., Lucas, T. G., Rassool, R. P., Balazs, C., Charles, T. K., Afanaciev, K., Emeliantchik, I., Ignatenko, A., Makarenko, V., Shumeiko, N., Patapenka, A., Zhuk, I., Hoffman, A. C. Abusleme, Gutierrez, M. A. Diaz, Gonzalez, M. Vogel, Chi, Y., He, X., Pei, G., Pei, S., Shu, G., Wang, X., Zhang, J., Zhao, F., Zhou, Z., Chen, H., Gao, Y., Huang, W., Kuang, Y. P., Li, B., Li, Y., Shao, J., Shi, J., Tang, C., Wu, X., Ma, L., Han, Y., Fang, W., Gu, Q., Huang, D., Huang, X., Tan, J., Wang, Z., Zhao, Z., Laštovička, T., Uggerhoj, U., Wistisen, T. N., Aabloo, A., Eimre, K., Kuppart, K., Vigonski, S., Zadin, V., Aicheler, M., Baibuz, E., Brücken, E., Djurabekova, F., Eerola, P., Garcia, F., Haeggström, E., Huitu, K., Jansson, V., Karimaki, V., Kassamakov, I., Kyritsakis, A., Lehti, S., Meriläinen, A., Montonen, R., Niinikoski, T., Nordlund, K., Österberg, K., Parekh, M., Törnqvist, N. A., Väinölä, J., Veske, M., Farabolini, W., Mollard, A., Napoly, O., Peauger, F., Plouin, J., Bambade, P., Chaikovska, I., Chehab, R., Davier, M., Kaabi, W., Kou, E., LeDiberder, F., Pöschl, R., Zerwas, D., Aimard, B., Balik, G., Baud, J. -P., Blaising, J. -J., Brunetti, L., Chefdeville, M., Drancourt, C., Geoffroy, N., Jacquemier, J., Jeremie, A., Karyotakis, Y., Nappa, J. M., Vilalte, S., Vouters, G., Bernard, A., Peric, I., Gabriel, M., Simon, F., Szalay, M., van der Kolk, N., Alexopoulos, T., Gazis, E. N., Gazis, N., Ikarios, E., Kostopoulos, V., Kourkoulis, S., Gupta, P. D., Shrivastava, P., Arfaei, H., Dayyani, M. K., Ghasem, H., Hajari, S. S., Shaker, H., Ashkenazy, Y., Abramowicz, H., Benhammou, Y., Borysov, O., Kananov, S., Levy, A., Levy, I., Rosenblat, O., D'Auria, G., Di Mitri, S., Abe, T., Aryshev, A., Higo, T., Makida, Y., Matsumoto, S., Shidara, T., Takatomi, T., Takubo, Y., Tauchi, T., Toge, N., Ueno, K., Urakawa, J., Yamamoto, A., Yamanaka, M., Raboanary, R., Hart, R., van der Graaf, H., Eigen, G., Zalieckas, J., Adli, E., Lillestøl, R., Malina, L., Pfingstner, J., Sjobak, K. N., Ahmed, W., Asghar, M. I., Hoorani, H., Bugiel, S., Dasgupta, R., Firlej, M., Fiutowski, T. A., Idzik, M., Kopec, M., Kuczynska, M., Moron, J., Swientek, K. P., Daniluk, W., Krupa, B., Kucharczyk, M., Lesiak, T., Moszczynski, A., Pawlik, B., Sopicki, P., Wojtoń, T., Zawiejski, L., Kalinowski, J., Krawczyk, M., Żarnecki, A. F., Firu, E., Ghenescu, V., Neagu, A. T., Preda, T., Zgura, I-S., Aloev, A., Azaryan, N., Budagov, J., Chizhov, M., Filippova, M., Glagolev, V., Gongadze, A., Grigoryan, S., Gudkov, D., Karjavine, V., Lyablin, M., Olyunin, A., Samochkine, A., Sapronov, A., Shirkov, G., Soldatov, V., Solodko, A., Solodko, E., Trubnikov, G., Tyapkin, I., Uzhinsky, V., Vorozhtov, A., Levichev, E., Mezentsev, N., Piminov, P., Shatilov, D., Vobly, P., Zolotarev, K., Jelisavcic, I. Bozovic, Kacarevic, G., Lukic, S., Milutinovic-Dumbelovic, G., Pandurovic, M., Iriso, U., Perez, F., Pont, M., Trenado, J., Aguilar-Benitez, M., Calero, J., Garcia-Tabares, L., Gavela, D., Gutierrez, J. L., Lopez, D., Toral, F., Moya, D., Jimeno, A. Ruiz, Vila, I., Argyropoulos, T., Gutierrez, C. Blanch, Boronat, M., Esperante, D., Faus-Golfe, A., Fuster, J., Martinez, N. Fuster, Muñoz, N. Galindo, García, I., Navarro, J. Giner, Ros, E., Vos, M., Brenner, R., Ekelöf, T., Jacewicz, M., Ögren, J., Olvegård, M., Ruber, R., Ziemann, V., Aguglia, D., Tehrani, N. Alipour, Andersson, A., Andrianala, F., Antoniou, F., Artoos, K., Atieh, S., Sune, R. Ballabriga, Barnes, M. J., Garcia, J. Barranco, Bartosik, H., Belver-Aguilar, C., Morell, A. Benot, Bett, D. R., Bettoni, S., Blanchot, G., Garcia, O. Blanco, Bonnin, X. A., Brunner, O., Burkhardt, H., Calatroni, S., Campbell, M., Lasheras, N. Catalan, Bastos, M. Cerqueira, Cherif, A., Chevallay, E., Constance, B., Corsini, R., Cure, B., Curt, S., Dalena, B., Dannheim, D., De Michele, G., De Oliveira, L., Deelen, N., Delahaye, J. P., Dobers, T., Doebert, S., Draper, M., Ramos, F. Duarte, Dubrovskiy, A., Elsener, K., Esberg, J., Esposito, M., Fedosseev, V., Ferracin, P., Fiergolski, A., Foraz, K., Fowler, A., Friebel, F., Fuchs, J-F., Rojas, C. A. Fuentes, Gaddi, A., Fajardo, L. Garcia, Morales, H. Garcia, Garion, C., Gatignon, L., Gayde, J-C., Gerwig, H., Goldblatt, A. N., Grefe, C., Grudiev, A., Guillot-Vignot, F. G., Gutt-Mostowy, M. L., Hauschild, M., Hessler, C., Holma, J. K., Holzer, E., Hourican, M., Hynds, D., Levinsen, Y. Inntjore, Jeanneret, B., Jensen, E., Jonker, M., Kastriotou, M., Kemppinen, J. M. K., Kieffer, R. B., Klempt, W., Kononenko, O., Korsback, A., Platia, E. Koukovini, Kovermann, J. W., Kozsar, C-I., Kremastiotis, I., Kulis, S., Latina, A., Leaux, F., Lebrun, P., Lefevre, T., Linssen, L., Cudie, X. Llopart, Maier, A. A., Durand, H. Mainaud, Manosperti, E., Marelli, C., Lacoma, E. Marin, Martin, R., Mazzoni, S., Mcmonagle, G., Mete, O., Mether, L. M., Modena, M., Münker, R. M., Muranaka, T., Del Busto, E. Nebot, Nikiforou, N., Nisbet, D., Nonglaton, J-M., Nuiry, F. X., Nürnberg, A., Olvegard, M., Osborne, J., Papadopoulou, S., Papaphilippou, Y., Passarelli, A., Patecki, M., Pazdera, L., Pellegrini, D., Pepitone, K., Codina, E. Perez, Fontenla, A. Perez, Persson, T. H. B., Petrič, M., Pitters, F., Pittet, S., Plassard, F., Rajamak, R., Redford, S., Renier, Y., Rey, S. F., Riddone, G., Rinolfi, L., Castro, E. Rodriguez, Roloff, P., Rossi, C., Rude, V., Rumolo, G., Sailer, A., Santin, E., Schlatter, D., Schmickler, H., Schulte, D., Shipman, N., Sicking, E., Simoniello, R., Skowronski, P. K., Mompean, P. Sobrino, Soby, L., Sosin, M. P., Sroka, S., Stapnes, S., Sterbini, G., Ström, R., Syratchev, I., Tecker, F., Thonet, P. A., Timeo, L., Timko, H., Garcia, R. Tomas, Valerio, P., Vamvakas, A. L., Vivoli, A., Weber, M. A., Wegner, R., Wendt, M., Woolley, B., Wuensch, W., Uythoven, J., Zha, H., Zisopoulos, P., Benoit, M., Pinto, M. Vicente Barreto, Bopp, M., Braun, H. H., Divall, M. Csatari, Dehler, M., Garvey, T., Raguin, J. Y., Rivkin, L., Zennaro, R., Aksoy, A., Nergiz, Z., Pilicer, E., Tapan, I., Yavas, O., Baturin, V., Kholodov, R., Lebedynskyi, S., Miroshnichenko, V., Mordyk, S., Profatilova, I., Storizhko, V., Watson, N., Winter, A., Goldstein, J., Green, S., Marshall, J. S., Thomson, M. A., Xu, B., Gillespie, W. A., Pan, R., Tyrk, M. A, Protopopescu, D., Robson, A., Apsimon, R., Bailey, I., Burt, G., Constable, D., Dexter, A., Karimian, S., Lingwood, C., Buckland, M. D., Casse, G., Vossebeld, J., Bosco, A., Karataev, P., Kruchinin, K., Lekomtsev, K., Nevay, L., Snuverink, J., Yamakawa, E., Boisvert, V., Boogert, S., Boorman, G., Gibson, S., Lyapin, A., Shields, W., Teixeira-Dias, P., West, S., Jones, R., Joshi, N., Bodenstein, R., Burrows, P. N., Christian, G. B., Gamba, D., Perry, C., Roberts, J., Clarke, J. A., Collomb, N. A., Jamison, S. P., Shepherd, B. J. A., Walsh, D., Demarteau, M., Repond, J., Weerts, H., Xia, L., Wells, J. D., Adolphsen, C., Barklow, T., Breidenbach, M., Graf, N., Hewett, J., Markiewicz, T., McCormick, D., Moffeit, K., Nosochkov, Y., Oriunno, M., Phinney, N., Rizzo, T., Tantawi, S., Wang, F., Wang, J., White, G., Woodley, M.

The Compact Linear Collider (CLIC) is a multi-TeV high-luminosity linear e+e- collider under development. For an optimal exploitation of its physics potential, CLIC is foreseen to be built and operated in a staged approach with three centre-of-mass e

Externí odkaz: http://arxiv.org/abs/1608.07537