Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Lingquan, Deng"'
Autor:
Frederico Alisson-Silva, Janet Z Liu, Sandra L Diaz, Lingquan Deng, Mélanie G Gareau, Ronald Marchelletta, Xi Chen, Victor Nizet, Nissi Varki, Kim E Barrett, Ajit Varki
Publikováno v:
PLoS Pathogens, Vol 14, Iss 6, p e1007133 (2018)
While infectious agents have typical host preferences, the noninvasive enteric bacterium Vibrio cholerae is remarkable for its ability to survive in many environments, yet cause diarrheal disease (cholera) only in humans. One key V. cholerae virulenc
Externí odkaz:
https://doaj.org/article/d8eece3bd5ab40258f018d5c5185de58
Autor:
Martijn A. Langereis, Mark J.G. Bakkers, Lingquan Deng, Vered Padler-Karavani, Stephin J. Vervoort, Ruben J.G. Hulswit, Arno L.W. van Vliet, Gerrit J. Gerwig, Stefanie A.H. de Poot, Willemijn Boot, Anne Marie van Ederen, Balthasar A. Heesters, Chris M. van der Loos, Frank J.M. van Kuppeveld, Hai Yu, Eric G. Huizinga, Xi Chen, Ajit Varki, Johannis P. Kamerling, Raoul J. de Groot
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1966-1978 (2015)
Sialic acids (Sias), 9-carbon-backbone sugars, are among the most complex and versatile molecules of life. As terminal residues of glycans on proteins and lipids, Sias are key elements of glycotopes of both cellular and microbial lectins and thus act
Externí odkaz:
https://doaj.org/article/c810e7e811be4ad3b07b1a33d7f7d1fb
Autor:
Lingquan Deng, Theresa Lindhout-Djukic, Melissa J. Schur, Lisa A. Lewis, Ajit Varki, Sunita Gulati, Sanjay Ram, Corinna S. Landig, Sudeshna Saha, Ian C. Schoenhofen, Bo Zheng
Publikováno v:
The Journal of Immunology. 204:3283-3295
Neisseria gonorrhoeae deploys a unique immune evasion strategy wherein the lacto-N-neotetraose termini of lipooligosaccharide (LOS) are “capped” by a surface LOS sialyltransferase (Lst), using extracellular host-derived CMP-sialic acid (CMP-Neu5A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b60cae5627fc81ae4c669390a72415
https://doi.org/10.4049/jimmunol.1901398
https://doi.org/10.4049/jimmunol.1901398
Autor:
Lingquan Deng, Barbara A Bensing, Supaporn Thamadilok, Hai Yu, Kam Lau, Xi Chen, Stefan Ruhl, Paul M Sullam, Ajit Varki
Publikováno v:
PLoS Pathogens, Vol 10, Iss 12, p e1004540 (2014)
Damaged cardiac valves attract blood-borne bacteria, and infective endocarditis is often caused by viridans group streptococci. While such bacteria use multiple adhesins to maintain their normal oral commensal state, recognition of platelet sialoglyc
Externí odkaz:
https://doaj.org/article/d28874d67caf44c3950c92a9cf3b9341
Autor:
Sohyoung Lee, Lingquan Deng, Jun Zhao, Jeongmin Song, Ruth Nussinov, Buyankhishig Tsogtbaatar, Andrew J. Thompson, Yi-An Yang, James C. Paulson, Ryan McBride
Publikováno v:
Nature Microbiology. 3:155-163
Typhoid fever is a life-threatening disease, but little is known about the molecular bases for its unique clinical presentation. Typhoid toxin, a unique virulence factor of Salmonella Typhi (the cause of typhoid fever), recapitulates in an animal mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff166003cac1286b908749903fb566e
https://doi.org/10.1038/s41564-017-0076-4
https://doi.org/10.1038/s41564-017-0076-4
Autor:
Cristina C. Rohena, Sandra Diaz, Lingquan Deng, Ismael Secundino, Victor Nizet, Pradipta Ghosh, Anel Lizcano, Simon Döhrmann, Ajit Varki, Ross Corriden
Publikováno v:
Blood. 129:3100-3110
Healthy blood neutrophils are functionally quiescent in the bloodstream, have a short lifespan, and exit the circulation to carry out innate immune functions, or undergo rapid apoptosis and macrophage-mediated clearance to mitigate host tissue damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adf1263ab564988ac160b08a0a4003f
https://doi.org/10.1182/blood-2016-11-751636
https://doi.org/10.1182/blood-2016-11-751636
Autor:
Sunita, Gulati, Ian C, Schoenhofen, Theresa, Lindhout-Djukic, Melissa J, Schur, Corinna S, Landig, Sudeshna, Saha, Lingquan, Deng, Lisa A, Lewis, Bo, Zheng, Ajit, Varki, Sanjay, Ram
Publikováno v:
J Immunol
Neisseria gonorrhoeae deploys a unique immune evasion strategy wherein the lacto-N-neotetraose (LNnT) termini of lipooligosaccharide (LOS) are capped by a surface sialyltransferase (Lst), utilizing extracellular host-derived CMP-sialic acid (CMP-Neu5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bcb3171ca6891c6eeeffda75e2c7aab
https://pubmed.ncbi.nlm.nih.gov/32434942
https://pubmed.ncbi.nlm.nih.gov/32434942
Autor:
Lingquan Deng, Frederico Alisson-Silva, Janet Z. Liu, Ajit Varki, Mélanie G. Gareau, Kim E. Barrett, Nissi Varki, Sandra Diaz, Ronald R. Marchelletta, Xi Chen, Victor Nizet
Publikováno v:
PLoS pathogens, vol 14, iss 6
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 6, p e1007133 (2018)
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 6, p e1007133 (2018)
While infectious agents have typical host preferences, the noninvasive enteric bacterium Vibrio cholerae is remarkable for its ability to survive in many environments, yet cause diarrheal disease (cholera) only in humans. One key V. cholerae virulenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e066df971ecbd3cd537046cfcd5c33
https://escholarship.org/uc/item/9z44t3pn
https://escholarship.org/uc/item/9z44t3pn
Autor:
Hai Yu, Lingquan Deng, Xi Chen, Gabrielle Stack, Ajit Varki, Xiang Gao, Yuko Naito-Matsui, Jorge E. Galán
Publikováno v:
Nature microbiology, vol 2, iss 12
Nature microbiology
Nature microbiology
The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b6d869da263ae655622951fe4a8494
https://escholarship.org/uc/item/3xx5t709
https://escholarship.org/uc/item/3xx5t709
Autor:
Jeongmin Song, Ajit Varki, Lingquan Deng, Xiang Gao, Yuko Naito-Matsui, Nissi Varki, Jiawei Wang, Hai Yu, Jorge E. Galán, Xi Chen
Publikováno v:
Cell, vol 159, iss 6
SummarySalmonella Typhi is an exclusive human pathogen that causes typhoid fever. Typhoid toxin is a S. Typhi virulence factor that can reproduce most of the typhoid fever symptoms in experimental animals. Toxicity depends on toxin binding to termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23c8bdd52ce034b178d1a803ed16329