Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Lingming Liang"'
Autor:
Cong Li, Ye Shen, Patrick Collins, Lingming Liang, Olivier Nolan-Stevaux, Jason S Eng, Flordeliza Fajardo, Donato Tedesco
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Bispecific T-cell engager (BiTE) molecules induce redirected lysis of cancer cells by T cells and are an emerging modality for solid tumor immunotherapy. While signs of clinical activity have been demonstrated, efficacy of T-cell engagers
Externí odkaz:
https://doaj.org/article/d39bd0b760a04a6d889d1ab1cd2713ed
Autor:
Cong Li, Gregory Moore, Umesh Muchhal, John Desjarlais, Matthew Bernett, Madeline Fort, Lingming Liang, Tao Osgood, Rodolfo Yabut, Sarav Kaliyaperumal, John Harrold, Jude Canon, Anna Rogojina, Raushan Kurmasheva, Peter Houghton, Olivier Nolan-Stevaux
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/9f44cfaebbde4a72a66c6cbe35d25b0b
Autor:
Kang Dai, Dineli Wickramasinghe, Alexander Kamb, Julio Medina, Lawrence R. McGee, Christophe Quéva, Timothy Carlson, Lily Liu, Ada Chen, Rachel Ngo, Sharon Zhao, Mei-Chu Lo, Jessica Orf, Grace Alba, Xianghong Wang, Justin Huard, Margaret Weidner, Lingming Liang, John Eksterowicz, David Hollenback, Suzanne Coberly, Mark Ragains, Ji Ma, Zhihong Li, Cong Li, Kathleen Keegan
PDF file - 132KB, Figure S1. Plasma concentration-time profiles of AMG 925 in rat, dog, and cynomolgus monkey following oral administration. Figure S2. Inhibition of STAT5 and Rb phosphorylation by AMG 925 in MOLM13-Luc tumor cells in bone marrow. Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216ae1da07e58a29878dbe9dcd4275af
https://doi.org/10.1158/1535-7163.22499853
https://doi.org/10.1158/1535-7163.22499853
Autor:
Kang Dai, Dineli Wickramasinghe, Alexander Kamb, Angus Sinclair, Katie Newhall, Lawrence R. McGee, Xianghong Wang, Zhihong Li, Zhen Xia, Lingming Liang, Liqin Liu, Cong Li
Supplementary Tables S1-S3. Table S1. AMG 925 is a FLT3/CDK4 dual inhibitor; Table S2. AMG 925 resistant cells are also resistant to AC220 and sorafenib; Table S3 AMG 925 activity in Ba/F3 FLT3-ITD cells isolated from AC220 culture expression various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b766b004fc57fdb6f2f79223ccc0383
https://doi.org/10.1158/1535-7163.22503457
https://doi.org/10.1158/1535-7163.22503457
Publikováno v:
International Journal of Computer Integrated Manufacturing. 34:293-306
Existing CAD model classification methods are usually performed by extracting the geometric and topological information of the models. This is not suitable for the classification of Model-based Def...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a90117d811795982c9224a47d626f6
https://doi.org/10.1080/0951192x.2021.1872102
https://doi.org/10.1080/0951192x.2021.1872102
Autor:
Ye Shen, Jason S Eng, Flordeliza Fajardo, Lingming Liang, Cong Li, Patrick Collins, Donato Tedesco, Olivier Nolan-Stevaux
Publikováno v:
Journal for ImmunoTherapy of Cancer. 10:e004348
BackgroundBispecific T-cell engager (BiTE) molecules induce redirected lysis of cancer cells by T cells and are an emerging modality for solid tumor immunotherapy. While signs of clinical activity have been demonstrated, efficacy of T-cell engagers (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf837ee1bb9b725c457d2981624d7b3e
https://doi.org/10.1136/jitc-2021-004348
https://doi.org/10.1136/jitc-2021-004348
Autor:
Raushan Kurmasheva, Olivier Nolan-Stevaux, John R. Desjarlais, Matthew J. Bernett, Peter J. Houghton, Rodolfo Yabut, Cong Li, Tao Osgood, Anna Rogojina, Umesh Muchhal, Madeline M. Fort, Jude Canon, Gregory T. Moore, John M. Harrold, Sarav Kaliyaperumal, Lingming Liang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Metastatic castration-resistant prostate cancer (mCRPC) and Ewing sarcoma (EWS) are diseases for which immune therapies could potentially provide benefit. STEAP1 (Six Transmembrane Epithelial Antigen of the Prostate 1) is a cell surface pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76db3a38e8fb53797b6ab1ab10f35a2
https://doaj.org/article/9f44cfaebbde4a72a66c6cbe35d25b0b
https://doaj.org/article/9f44cfaebbde4a72a66c6cbe35d25b0b
Autor:
Zhen Xia, Lawrence R. McGee, Liqin Liu, Dineli Wickramasinghe, Katie Newhall, Zhihong Li, Xianghong Wang, Lingming Liang, Alexander Kamb, Cong Li, Kang Dai, Angus M. Sinclair
Publikováno v:
Molecular Cancer Therapeutics. 14:375-383
Resistance to FLT3 inhibitors is a serious clinical issue in treating acute myelogenous leukemia (AML). AMG 925, a dual FLT3/CDK4 inhibitor, has been developed to overcome this resistance. It is hypothesized that the combined inhibition of FLT3 and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced8e4d2611ca918ce5da8b21a38beb8
https://doi.org/10.1158/1535-7163.mct-14-0388
https://doi.org/10.1158/1535-7163.mct-14-0388
Autor:
Leping Li, Juan C. Jaen, Qiuping Ye, Jin-Long Chen, Pingchen Fan, Ying Fu, Kang Dai, Sylvia Wong, Xiaoqi Chen, Lingming Liang, Jeffrey T. Mihalic, Michelle Lindstrom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:363-366
A series of spiropiperidine carbazoles were synthesized and evaluated as MCHR2 antagonists using a FLIPR assay. The pharmacokinetic properties of selected compounds have also been studied. This effort led to the discovery of potent and specific MCHR2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee66bf8e63e74df6bb7a879725728b97
https://doi.org/10.1016/j.bmcl.2011.10.125
https://doi.org/10.1016/j.bmcl.2011.10.125
Autor:
Kang Dai, Ying Fu, Lingming Liang, Jin-Long Chen, Michael Reed, Liang Tang, Xi Chen, Jeffrey T. Mihalic, Juan C. Jaen, Pingchen Fan, Leping Li, Xiaoqi Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7001-7005
A new class of MCHR1 antagonists was discovered via a high-throughput screen. Optimization of the lead structure resulted in the identification of indole 10e. This compound possesses good pharmacokinetic properties across preclinical species and is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c56148e938995b5e5d2e7cc9afe3a2
https://doi.org/10.1016/j.bmcl.2011.09.110
https://doi.org/10.1016/j.bmcl.2011.09.110