Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Lingli He"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 752-758 (2024)
Gastric cancer (GC) is one of the most commonly diagnosed malignancies, threatening millions of lives worldwide each year. Importantly, GC is a heterogeneous disease, posing a significant challenge to the selection of patients for more optimized ther
Externí odkaz:
https://doaj.org/article/9d45be7013df4f9d9e2a2db042b00fc5
Autor:
Yuhang Wang, Chengcai Pan, Qihao Chen, Qing Xie, Yiwei Gao, Lingli He, Yue Li, Yanli Dong, Xingyu Jiang, Yan Zhao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Salt-overly-sensitive 1 (SOS1) is a unique electroneutral Na+/H+ antiporter at the plasma membrane of higher plants and plays a central role in resisting salt stress. SOS1 is kept in a resting state with basal activity and activated upon pho
Externí odkaz:
https://doaj.org/article/7a5b81916fe74fad8d6f8555820f8061
Publikováno v:
Remote Sensing, Vol 16, Iss 9, p 1551 (2024)
A polarized bidirectional reflectance distribution function (pBRDF) matrix was developed based on the two-scale roughness theory to provide consistent simulations of fully polarized microwave emission and scattering, required for the ocean–atmosphe
Externí odkaz:
https://doaj.org/article/2bf8f71836994e5eaa6379c53430bd63
Autor:
Lingli He, Zhuoya Yu, Ze Geng, Zhuo Huang, Changjiang Zhang, Yanli Dong, Yiwei Gao, Yuhang Wang, Qihao Chen, Le Sun, Xinyue Ma, Bo Huang, Xiaoqun Wang, Yan Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
T-type calcium channels are implicated in many diseases. Here, multiple structures of CaV3.3 channel elucidate molecular mechanisms of T-type CaV channels activation at low voltage and interaction with different clinically used channel blockers.
Externí odkaz:
https://doaj.org/article/2c869b74b72d42eebb9bd7d68d55ac63
Autor:
Jingqiang Wang, Chunye Liu, Lingli He, Zhiyao Xie, Lanyue Bai, Wentao Yu, Zuoyun Wang, Yi Lu, Dong Gao, Junfen Fu, Lei Zhang, Yi Arial Zeng
Publikováno v:
eLife, Vol 11 (2022)
Ovarian surface epithelium (OSE) undergoes recurring ovulatory rupture and OSE stem cells rapidly generate new cells for the repair. How the stem cell activation is triggered by the rupture and promptly turns on proliferation is unclear. Our previous
Externí odkaz:
https://doaj.org/article/91385240a3f54866ab713b7e7816a301
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
It is now clear that major malignancies are heterogeneous diseases associated with diverse molecular properties and clinical outcomes, posing a great challenge for more individualized therapy. In the last decade, cancer molecular subtyping studies we
Externí odkaz:
https://doaj.org/article/9c23852d133a4386ba43dbd6444dc67d
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100445- (2021)
Summary: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide. However, the pathogenesis of HCC is complicated, and the drugs used for HCC treatment are limited. The following protocol combines a genetically engineered
Externí odkaz:
https://doaj.org/article/880480ef3fc2417ba6d79bc62d9c04d2
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100504- (2021)
Summary: Sequential chromatin immunoprecipitation (ChIP) is commonly used to investigate DNA-protein and protein-protein interactions to a specific genomic region. However, it can be tricky to achieve a robust and reproducible signal with sequential
Externí odkaz:
https://doaj.org/article/60b878b70ce7414c940a43c8e50b32ea
Publikováno v:
BMC Plant Biology, Vol 19, Iss 1, Pp 1-19 (2019)
Abstract Background The PHOSPHATE1 (PHO1) gene family plays diverse roles in inorganic phosphate (Pi) transfer and signal transduction, and plant development. However, the functions and diversification of soybean PHO1 family are poorly understood. Re
Externí odkaz:
https://doaj.org/article/7725b7534509416b982250db69959e2a
Autor:
Lingli He, Liang Yuan, Wentao Yu, Yang Sun, Dan Jiang, Xiaodong Wang, Xue Feng, Zuoyun Wang, Jinjin Xu, Ruizeng Yang, Wenxiang Zhang, Hua Feng, Hang-zi Chen, Yi Arial Zeng, Lijian Hui, Qiao Wu, Yonglong Zhang, Lei Zhang
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108284- (2020)
Summary: The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hi
Externí odkaz:
https://doaj.org/article/3073b7c2389a4f9a8a749e7f97c29550