Zobrazeno 1 - 10
of 996
pro vyhledávání: '"Lingjun Li"'
Autor:
Yaxian Zhou, Chunrong Li, Xuankun Chen, Yuan Zhao, Yaxian Liao, Penghsuan Huang, Wenxin Wu, Nicholas S. Nieto, Lingjun Li, Weiping Tang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Targeted protein degradation has emerged as a novel therapeutic modality to treat human diseases by utilizing the cell’s own disposal systems to remove protein target. Significant clinical benefits have been observed for degrading many int
Externí odkaz:
https://doaj.org/article/2fb5fe98fda44ef286be9db01fc87726
Autor:
Ziyi Lin, Lingling Xu, Chen Yang, Gaojie Chen, Xiaoting Ji, Lingjun Li, Keran Zhang, Youwei Hong, Mengren Li, Xiaolong Fan, Baoye Hu, Fuwang Zhang, Jinsheng Chen
Publikováno v:
npj Climate and Atmospheric Science, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Peroxyacetyl nitrate (PAN) is an important photochemical product and affects ozone (O3) formation in the troposphere. Yet, the long-term observation of PAN remains scarce, limiting the full understanding of its impacts on photochemical pollu
Externí odkaz:
https://doaj.org/article/6b59971164c94d8e996f6b0be79a4547
Autor:
Shuling Xu, Zhijun Zhu, Daniel G. Delafield, Michael J. Rigby, Gaoyuan Lu, Megan Braun, Luigi Puglielli, Lingjun Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Dysregulated glycerophospholipid (GP) metabolism in the brain is associated with the progression of neurodegenerative diseases including Alzheimer’s disease (AD). Routine liquid chromatography-mass spectrometry (LC-MS)-based large-scale li
Externí odkaz:
https://doaj.org/article/faba655025324208a9ddfc0c7b1ce66b
Publikováno v:
npj Imaging, Vol 2, Iss 1, Pp 1-15 (2024)
Abstract The recent upswing in the integration of spatial multi-omics for conducting multidimensional information measurements is opening a new chapter in biological research. Mapping the landscape of various biomolecules including metabolites, prote
Externí odkaz:
https://doaj.org/article/831897a873474ded9f66c3a9fed261e9
Autor:
Chenxuan Zhao, Lei He, Lingjun Li, Fengying Deng, Meihua Zhang, Changhong Wang, Junlan Qiu, Qinqin Gao
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Glucocorticoids (GCs) are steroid hormones fundamental to the body’s normal physiological functions and are pivotal in fetal growth and development. During gestation, the mother’s cortisol concentration (active GCs) escalates to accommodate the r
Externí odkaz:
https://doaj.org/article/56e37e4e2dd34ed0906f05b69ce0ace6
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 4, Pp 459-466 (2024)
Objective To investigate the impact of midazolam on neuronal injury induced by oxygen glucose deprivation/reoxygenation(OGD/R) in mice. Methods An injury model of neuronal cell line HT22 was established by OGD/R induction. HT22 cells were divided int
Externí odkaz:
https://doaj.org/article/540c22ab377f46739847cd81b0bc3755
Publikováno v:
ACS Measurement Science Au, Vol 4, Iss 4, Pp 315-337 (2024)
Externí odkaz:
https://doaj.org/article/8b980733565b42029571571b2908881f
Autor:
Jinghua Hao, Xiaoli Wang, Yanhua Shi, Lingjun Li, Jinxin Chu, Junjie Li, Weiping Lin, Tao Yu, Dianhai Hou
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background The Inonotus obliquus mushroom, a wondrous fungus boasting edible and medicinal qualities, has been widely used as a folk medicine and shown to have many potential pharmacological secondary metabolites. The purpose of this study w
Externí odkaz:
https://doaj.org/article/8e32e7f602da43648f9440b5a5a8f946
Autor:
Hua Zhang, Yuan Liu, Lauren Fields, Xudong Shi, Penghsuan Huang, Haiyan Lu, Andrew J. Schneider, Xindi Tang, Luigi Puglielli, Nathan V. Welham, Lingjun Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Single-cell (SC) analysis provides unique insight into individual cell dynamics and cell-to-cell heterogeneity. Here, we utilize trapped ion mobility separation coupled with dual-polarity ionization mass spectrometry imaging (MSI) to enable
Externí odkaz:
https://doaj.org/article/c5590947bef34f65b5fde66ebc7f6df8
Autor:
Xiuliang Dai, Lingjun Li, Minhui Li, Xiaomeng Yan, Jinhang Li, Hao Mao, Cheng Wang, Hongbin Xu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115172- (2023)
Ovarian cancer is one of the most common gynecological cancers with high mortality rate. The battle against ovarian cancer usually impaired by the evolved multidrug resistance (MDR) phenotype as well as metastasis in cancers, which urgently call for
Externí odkaz:
https://doaj.org/article/e8dba312ae7f47a6b55896c8a6b5a4ab