Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lingjie, Sang"'
Autor:
Chengyu Shi, Ying Wang, Minjie Wu, Yu Chen, Fangzhou Liu, Zheyuan Shen, Yiran Wang, Shaofang Xie, Yingying Shen, Lingjie Sang, Zhen Zhang, Zerui Gao, Luojia Yang, Lei Qu, Zuozhen Yang, Xinyu He, Yu Guo, Chenghao Pan, Jinxin Che, Huaiqiang Ju, Jian Liu, Zhijian Cai, Qingfeng Yan, Luyang Yu, Liangjing Wang, Xiaowu Dong, Pinglong Xu, Jianzhong Shao, Yang Liu, Xu Li, Wenqi Wang, Ruhong Zhou, Tianhua Zhou, Aifu Lin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cancer cells exploit immune checkpoint pathways, such as PD-1/PD-L1, to evade elimination by the immune system. Here, the authors demonstrate that TMUB1 regulates post-translational modifications of PD-L1 and that targeting the TMUB1/PD-L1 interactio
Externí odkaz:
https://doaj.org/article/5c9afa68434c4156b9404910dc8406e1
Autor:
Qianqian Zhuang, Fengfeng Guo, Lei Fu, Yufei Dong, Shaofang Xie, Xue Ding, Shuangyi Hu, Xuanhao D. Zhou, Yangwei Jiang, Hui Zhou, Yue Qiu, Zhaoying Lei, Mengyao Li, Huajian Cai, Mingjie Fan, Lingjie Sang, Yong Fu, Dong Zhang, Aifu Lin, Xu Li, Tilo Kunath, Ruhong Zhou, Ping Liang, Zhong Liu, Qingfeng Yan
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Hypertrophic cardiomyopathy (HCM) is the most prominent cause of sudden cardiac death in young people. Due to heterogeneity in clinical manifestations, conventional HCM drugs have limitations for mitochondrial hypertrophic cardiomyopathy. Discovering
Externí odkaz:
https://doaj.org/article/c9d19fddd89f4d1ba21d12badf5c0d14
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Phosphorylation of L-type calcium CaV channels by protein kinase A is essential for several physiological events. Here, the authors show how this kinase regulates CaV1.4 activity, suggesting a general regulatory mechanism for all L-type calcium chann
Externí odkaz:
https://doaj.org/article/946e436012b54cc6a4181a4bbcf12a18
Publikováno v:
Cell Reports, Vol 14, Iss 12, Pp 3019-3029 (2016)
Biology has been revolutionized by tools that allow the detection and characterization of protein-protein interactions (PPIs). Förster resonance energy transfer (FRET)-based methods have become particularly attractive as they allow quantitative stud
Externí odkaz:
https://doaj.org/article/0d9403b9f8d54c9c9e42da8e3a31e835
Autor:
Zhen Zhang, Yun-xin Lu, Fangzhou Liu, Lingjie Sang, Chengyu Shi, Shaofang Xie, Weixiang Bian, Jie-cheng Yang, Zuozhen Yang, Lei Qu, Shi-yi Chen, Jun Li, Lu Yang, Qingfeng Yan, Wenqi Wang, Peifen Fu, Jianzhong Shao, Xu Li, Aifu Lin
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Notch has been implicated in human cancers and is a putative therapeutic target. However, the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore, characterizing the detailed mechanisms governing Notch degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f5d5b29d924b4f64eb490a3cae60466
https://doi.org/10.1073/pnas.2206694120
https://doi.org/10.1073/pnas.2206694120
Publikováno v:
Acta biochimica et biophysica Sinica. 54(3)
Long non-coding RNAs (lncRNAs) transcribed in mammals and eukaryotes were thought to have no protein coding capability. However, recent studies have suggested that plenty of lncRNAs are mis-annotated and virtually contain coding sequences which are t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badeae638d8e9253f22e149a7216ad48
https://pubmed.ncbi.nlm.nih.gov/35538037
https://pubmed.ncbi.nlm.nih.gov/35538037
Publikováno v:
Wiley interdisciplinary reviews. RNAREFERENCES. 13(6)
Eukaryotic cells contain subcellular organelles with spatiotemporal regulation to coordinate various biochemical reactions. The various organelles perform their essential biological functions by employing specific biomolecules, including nucleic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1084c554e5aa8d1caf0458f665cd7247
https://pubmed.ncbi.nlm.nih.gov/35413151
https://pubmed.ncbi.nlm.nih.gov/35413151
Autor:
Fangzhou Liu, Tian Tian, Zhen Zhang, Shanshan Xie, Jiecheng Yang, Linyu Zhu, Wen Wang, Chengyu Shi, Lingjie Sang, Kaiqiang Guo, Zuozhen Yang, Lei Qu, Xiangrui Liu, Jian Liu, Qingfeng Yan, Huai-qiang Ju, Wenqi Wang, Hai-long Piao, Jianzhong Shao, Tianhua Zhou, Aifu Lin
Publikováno v:
Nature metabolism. 4(8)
Cholesterol contributes to the structural basis of biological membranes and functions as a signaling molecule, whose dysregulation has been associated with various human diseases. Here, we report that the long non-coding RNA (lncRNA) SNHG6 increases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fbb81fe153e9152ec831d3a620ec8c
https://pubmed.ncbi.nlm.nih.gov/36068349
https://pubmed.ncbi.nlm.nih.gov/36068349
Autor:
Fangzhou Liu, Tian Tian, Zhen Zhang, Shanshan Xie, Jiecheng Yang, Linyu Zhu, Wen Wang, Chengyu Shi, Lingjie Sang, Kaiqiang Guo, Zuozhen Yang, Lei Qu, Xiangrui Liu, Jian Liu, Qingfeng Yan, Huai-qiang Ju, Wenqi Wang, Hai-long Piao, Jianzhong Shao, Tianhua Zhou, Aifu Lin
Publikováno v:
Nature Metabolism. 4:1215-1215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c269a878dc9b5247252b71e648dabf1
https://doi.org/10.1038/s42255-022-00650-5
https://doi.org/10.1038/s42255-022-00650-5
Ca2+/calmodulin-dependent inactivation (CDI) of CaV channels is a critical regulatory process required for tuning the kinetics of Ca2+ entry for different cell types and physiologic responses. Calmodulin (CaM) resides on the IQ domain of the CaV carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cf471f80ec59cad067238bd5278ed3c
https://doi.org/10.1101/2021.01.06.425618
https://doi.org/10.1101/2021.01.06.425618
