Výsledky vyhledávání - "Linghe Zhang"

Improving Tabletability of Excipients by Metal-Organic Framework-Based Cocrystallization: a Study of Mannitol and CaCl2

Autor: Yuan Gao, Wang Shiru, Yuanfeng Wei, Linghe Zhang, Shuai Qian, Jianjun Zhang, Weili Heng, Hao Cheng, Qiyang Qiao

Publikováno v: Pharmaceutical Research. 37

To improve tabletability of pharmaceutical excipient mannitol by forming cocrystal with metal-organic framework (MOF) structure. Mannitol was cocrystallized with CaCl2 by slurry method and solvent evaporation method. The obtained cocrystal was charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2687fcfb71872fb2f02f69e9ecad7383
https://doi.org/10.1007/s11095-020-02850-8

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Improving Tabletability of Excipients by Metal-Organic Framework-Based Cocrystallization: a Study of Mannitol and CaCl

Autor: Hao, Cheng, Yuanfeng, Wei, Shiru, Wang, Qiyang, Qiao, Weili, Heng, Linghe, Zhang, Jianjun, Zhang, Yuan, Gao, Shuai, Qian

Publikováno v: Pharmaceutical research. 37(7)

To improve tabletability of pharmaceutical excipient mannitol by forming cocrystal with metal-organic framework (MOF) structure.Mannitol was cocrystallized with CaClThe prepared cocrystal contains mannitol, CaClMOF-based cocrystallization will be a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1feebfb1c8c68903832e1e06d34a8bb8
https://pubmed.ncbi.nlm.nih.gov/32556798

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Incorporation of Complexation into a Coamorphous System Dramatically Enhances Dissolution and Eliminates Gelation of Amorphous Lurasidone Hydrochloride

Autor: Linghe Zhang, Shuai Qian, Yuanfeng Wei, Meiling Su, Peiya Shen, Hao Cheng, Yuan Gao, Weili Heng, Shujun Liang, Jianjun Zhang

Publikováno v: Molecular pharmaceutics. 17(1)

As a BCS II drug, the atypical antipsychotic agent lurasidone hydrochloride (LH) has low oral bioavailability mainly because of its poor aqueous solubility/dissolution. Unexpectedly, amorphous LH exhibited a much lower dissolution than that of its st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cd09d0ed32fffba9d202d32eca6974
https://pubmed.ncbi.nlm.nih.gov/31794225

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Gel Formation Induced Slow Dissolution of Amorphous Indomethacin

Autor: Linghe Zhang, Weili Heng, Yuan Gao, Yuanfeng Wei, Shuai Qian, Hao Cheng, Xue Yifan, Jianjun Zhang

Publikováno v: Pharmaceutical Research. 36

Amorphous indomethacin (IMC) forms gel with a decreased dissolution behavior compared to crystalline IMC during dissolution. The current study aims to explore gelation mechanism and attempt to eliminate gelling effect by formulation development. Amor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8023eb513877f0a188f75c8589f118
https://doi.org/10.1007/s11095-019-2700-x

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A novel drug-drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide

Autor: Yuan Gao, Yajing Shen, Yanming Xia, Shuai Qian, Weili Heng, Linghe Zhang, Meiling Su, Yuanfeng Wei, Jianjun Zhang

Publikováno v: RSC advances. 10(1)

Tadalafil and repaglinide, categorized as BCS class II drugs, have low oral bioavailabilities due to their poorly aqueous solubilities and dissolutions. The aim of this study was to enhance the dissolution of tadalafil and repaglinide by co-amorphiza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf975e4526d2a1475bf777a031334f2
https://pubmed.ncbi.nlm.nih.gov/35492562

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