Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lingguang Cui"'
Autor:
Radhika H Muzumdar, Derek M Huffman, Gil Atzmon, Christoph Buettner, Laura J Cobb, Sigal Fishman, Temuri Budagov, Lingguang Cui, Francine H Einstein, Aruna Poduval, David Hwang, Nir Barzilai, Pinchas Cohen
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6334 (2009)
Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). A novel mitochondria-associated peptide, Humanin (HN), has a
Externí odkaz:
https://doaj.org/article/3f99404b30f64a889176582ce9cc202c
Epigenetic modulation of β cells by interferon-α via PNPT1/mir-26a/TET2 triggers autoimmune diabetes
Autor:
Abora Ettela, Yaron Tomer, Zhengzi Yi, Lingguang Cui, Weijia Zhang, Mihaela Stefan-Lifshitz, Esra Karakose
Publikováno v:
JCI Insight. 4
Type 1 diabetes (T1D) is caused by autoimmune destruction of pancreatic β cells. Mounting evidence supports a central role for β cell alterations in triggering the activation of self-reactive T cells in T1D. However, the early deleterious events th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51390a45161c03ec825b3c71d6e3bf6
https://doi.org/10.1172/jci.insight.126663
https://doi.org/10.1172/jci.insight.126663
Autor:
Jessica Tozour, Hye Heo, Lingguang Cui, Fabien Delahaye, Francine H. Einstein, Yongmei Zhao, Nir Barzilai
Publikováno v:
Aging Cell
Summary Adverse environmental exposures of mothers during fetal period predispose offspring to a range of age-related diseases earlier in life. Here, we set to determine whether a deregulated epigenetic pattern is similar in young animals whose mothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0c4be32428feae447df064ebbb58ed
https://doi.org/10.1111/acel.12505
https://doi.org/10.1111/acel.12505
Autor:
Ting Zhang, Zhenwei Gong, Kai Su, H. Henry Dong, Radhika Muzumdar, Lingguang Cui, Emir Tas, Shoshana Yakar
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 309:E283-E292
Humanin (HN) is an endogenous mitochondria-associated peptide that has been shown to protect against various Alzheimer's disease-associated insults, myocardial ischemia-reperfusion injury, and reactive oxygen species-induced cell death. We have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfe3fb6425be81d557382d6622ab8a1
https://doi.org/10.1152/ajpendo.00043.2015
https://doi.org/10.1152/ajpendo.00043.2015
Autor:
Jaime Anguiano, Radhika Muzumdar, Lingguang Cui, Honghai Liu, Bernhard Kühn, Antonio Diaz, Zhenwei Gong, Ana Maria Cuervo, Regina Kuliawat, Emir Tas, Inmaculada Tasset
Publikováno v:
The Journal of Cell Biology
Gong et al. show in multiple cell types that a mitochondrial-associate peptide, humanin, activates chaperone-mediated autophagy (CMA) by stabilizing the interaction between HSP90 and CMA substrates, thereby protecting cells from stressor-induced cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6b75d8eedb9f4384faf94d21af4511
https://pubmed.ncbi.nlm.nih.gov/29187525
https://pubmed.ncbi.nlm.nih.gov/29187525
Autor:
Sandra E. Reznik, Richard W. Gelling, Patricia Vuguin, Albert F. Parlow, Robert G. Russell, Lingguang Cui, Xiu Quan Du, Maureen J. Charron, Sophia Ouhilal, Clara Karpovsky, Nannette Santoro
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 302:E522-E531
Alterations in insulin signaling as well as insulin action predispose to infertility as well as adverse pregnancy outcomes; however, little is known about the role of glucagon signaling in reproduction. The glucagon receptor knockout (Gcgr−/−) mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53a337f90b6579cc6d1838fc61302c9
https://doi.org/10.1152/ajpendo.00420.2011
https://doi.org/10.1152/ajpendo.00420.2011
Autor:
Susheel Gundewar, John W. Calvert, Saurabh Jha, Madhav Lavu, Sang Yong Ji, Yoni Weinberg, Anjana Nemkal, David J. Lefer, Derek M. Huffman, Benjamin L. Predmore, Radhika Muzumdar, Lingguang Cui, Laura E. Klein, Gil Atzmon
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:1940-1948
Objective— Humanin (HN), an endogenous antiapoptotic peptide, has previously been shown to protect against Alzheimer’s disease and a variety of cellular insults. We evaluated the effects of a potent analog of HN (HNG) in an in vivo murine model o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0e5b571ef0a27ed858b80e8dac30da
https://doi.org/10.1161/atvbaha.110.205997
https://doi.org/10.1161/atvbaha.110.205997
Autor:
Heidi Sørensen, Maureen J. Charron, Jens J. Holst, Peter B. Johansen, Lingguang Cui, Raymond A. Pederson, Xiu Quan Du, Patricia Vuguin, Christopher H.S. McIntosh, Richard W. Gelling, John Rømer, Norman Fleischer, Margarita Leiser, Erica Nishimura, Christian Fledelius
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 297:E695-E707
In addition to its primary role in regulating glucose production from the liver, glucagon has many other actions, reflected by the wide tissue distribution of the glucagon receptor (Gcgr). To investigate the role of glucagon in the regulation of insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d068c31b27b9d7e9501f87fda81453
https://doi.org/10.1152/ajpendo.00082.2009
https://doi.org/10.1152/ajpendo.00082.2009
Autor:
E. T. Brown, Barry E. Knox, Mohammad Haeri, J. C. Pan, Lingguang Cui, Yumiko Umino, Drew Everhart, T. H. Nguyen, A. S. Glenn, B. A. Frio, Eduardo Solessio, Robert B. Barlow, Maureen J. Charron, Gustav A. Engbretson, K. Cusato, R. Hafler
Publikováno v:
Proceedings of the National Academy of Sciences. 103:19541-19545
The retina is among the most metabolically active tissues in the body, requiring a constant supply of blood glucose to sustain function. We assessed the impact of low blood glucose on the vision of C57BL/6J mice rendered hypoglycemic by a null mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0a01c278ccae4952d6b4f1e349d538
https://doi.org/10.1073/pnas.0604478104
https://doi.org/10.1073/pnas.0604478104
Publikováno v:
American Journal of Obstetrics and Gynecology. 214:S136-S137
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3565e69903efe650a6a8933615bbdaa3
https://doi.org/10.1016/j.ajog.2015.10.268
https://doi.org/10.1016/j.ajog.2015.10.268