MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

Autor: Zelceski, Anabel, Francica, Paola, Lingg, Lea, Mutlu, Merve, Stok, Colin, Liptay, Martin, Alexander, John, Baxter, Joseph S., Brough, Rachel, Gulati, Aditi, Haider, Syed, Raghunandan, Maya, Song, Feifei, Sridhar, Sandhya, Forment, Josep V., O’Connor, Mark J., Davies, Barry R., van Vugt, Marcel A.T.M., Krastev, Dragomir B., Pettitt, Stephen J., Tutt, Andrew N.J., Rottenberg, Sven, Lord, Christopher J.

Publikováno v: In Cell Reports 30 May 2023 42(5)

Functional radiogenetic profiling implicates ERCC6L2 in non-homologous end joining

Autor: Francica, Paola, Mutlu, Merve, Blomen, Vincent A, Oliveira, Catarina, Nowicka, Zuzanna, Trenner, Anika, Gerhards, Nora M, Bouwman, Peter, Stickel, Elmer, Hekkelman, Maarten L, Lingg, Lea, Klebic, Ismar, van de Ven, Marieke, de Korte-Grimmerink, Renske, Howald, Denise, Jonkers, Jos, Sartori, Alessandro A, Fendler, Wojciech, Chapman, J Ross, Brummelkamp, Thijn, Rottenberg, Sven

Publikováno v: Franica, Paola; Mutlu, Merve; Blomen, Vincent A.; Oliveira, Catarina; Nowicka, Zuzanna; Trenner, Anika; Gerhards, Nora M.; Bouwman, Peter; Stickel, Elmer; Hekkelman, Maarten L.; Lingg, Lea; Klebic, Ismar; van den Ven, Marieke; de Korte-Grimmerink, Renske; Howald, Denise; Jonkers, Jos; Sartori, Alessandro A.; Fendler, Wojciech; Chapman, J. Ross; Brummelkamp, Thijn; ... (2020). Functional radiogenetic profiling implicates ERCC6L2 in non-homologous end joining. Cell reports, 32(8), p. 108068. Cell Press 10.1016/j.celrep.2020.108068
Cell Reports, 32(8), 108068
Cell Reports, Vol 32, Iss 8, Pp 108068-(2020)

Summary: Using genome-wide radiogenetic profiling, we functionally dissect vulnerabilities of cancer cells to ionizing radiation (IR). We identify ERCC6L2 as a major determinant of IR response, together with classical DNA damage response genes and me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e326fd011ac35ef74bdebb6db7847d24
https://boris.unibe.ch/146234/2/Figure1.pdf

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.

Autor: Francica P; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Mutlu M; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Blomen VA; Division of Biochemistry, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands., Oliveira C; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Nowicka Z; Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland., Trenner A; Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland., Gerhards NM; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Bouwman P; Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands., Stickel E; Division of Biochemistry, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands., Hekkelman ML; Division of Biochemistry, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands., Lingg L; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Klebic I; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., van de Ven M; Mouse Clinic for Cancer and Aging Research (MCCA), Preclinical Intervention Unit, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands., de Korte-Grimmerink R; Mouse Clinic for Cancer and Aging Research (MCCA), Preclinical Intervention Unit, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands., Howald D; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland., Jonkers J; Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands., Sartori AA; Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland., Fendler W; Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Chapman JR; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Brummelkamp T; Division of Biochemistry, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands., Rottenberg S; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Bern Center for Precision Medicine, University of Bern, 3012 Bern, Switzerland. Electronic address: sven.rottenberg@vetsuisse.unibe.ch.

Publikováno v: Cell reports [Cell Rep] 2020 Aug 25; Vol. 32 (8), pp. 108068.