The discovery of (1R, 3R)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile, a potent and selective agonist of human transient receptor potential cation channel subfamily m member 5 (TRPM5) and evaluation of as a potential gastrointestinal prokinetic agent

Autor: Sabat, M., Raveglia, L.F., Aldegheri, L., Barilli, A., Bianchi, F., Brault, L., Brodbeck, D., Feriani, A., Lingard, I., Miura, J., Myers, R., Piccoli, L., Tassini, S., Tyhonas, J., Ton-Nu, T., Wang, H., Virginio, C.

Publikováno v: In Bioorganic & Medicinal Chemistry 15 December 2022 76

Lingard: I got false promises at United, it was a lack of respect.

Autor: TOM COLLOMOSSE

Publikováno v: Daily Mail; 12/27/2022, p56, 2p

Studies of antibacterial activity (in vitro and in vivo) and mode of action for des-acyl tridecaptins (DATs).

Autor: Couturier C; Evotec, 1541, Avenue Marcel Mérieux, 69280, Marcy L'Etoile, France. Electronic address: cedric.couturier@evotec.com., Ronzon Q; Evotec, 1541, Avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Lattanzi G; Evotec-Aptuit (Verona) Srl, Via Alessandro Fleming 4, 37135, Verona, Italy., Lingard I; Evotec-Aptuit (Verona) Srl, Via Alessandro Fleming 4, 37135, Verona, Italy., Coyne S; Evotec, 40 Avenue Tony Garnier, 69007, Lyon, France., Cazals V; Evotec, 40 Avenue Tony Garnier, 69007, Lyon, France., Dubarry N; Evotec, 40 Avenue Tony Garnier, 69007, Lyon, France., Yvon S; Evotec, 40 Avenue Tony Garnier, 69007, Lyon, France., Leroi-Geissler C; Evotec, 40 Avenue Tony Garnier, 69007, Lyon, France., Gracia OR; Evotec, 195, Route D'Espagne, 31100, Toulouse, France., Teague J; Evotec, No. 23F, Mereside, Alderley Park, Cheshire, SK10 4TG, United Kingdom., Sordello S; Evotec, 195, Route D'Espagne, 31100, Toulouse, France., Corbett D; Evotec, No. 23F, Mereside, Alderley Park, Cheshire, SK10 4TG, United Kingdom., Bauch C; Evotec-Cyprotex, No. 24, Mereside, Alderley Park, Cheshire, SK10 4TG, United Kingdom., Monlong C; Evotec, 40 Avenue Tony Garnier, 69007, Lyon, France., Payne L; Evotec, No. 23F, Mereside, Alderley Park, Cheshire, SK10 4TG, United Kingdom., Taillier T; Evotec, 195, Route D'Espagne, 31100, Toulouse, France., Fuchs H; Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstraße 7, 38124, Braunschweig, Germany., Broenstrup M; Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstraße 7, 38124, Braunschweig, Germany., Harrison PH; Division of Structural Biology, Wellcome Trust Centre of Human Genomics, 7 Roosevelt Drive, Oxford, OX3 7BN, United Kingdom., Moynié L; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Didcot, OX11 0QS, United Kingdom., Lakshminarayanan A; Division of Structural Biology, Wellcome Trust Centre of Human Genomics, 7 Roosevelt Drive, Oxford, OX3 7BN, United Kingdom., Gianga TM; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, OX11 0DE, United Kingdom., Hussain R; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, OX11 0DE, United Kingdom., Naismith JH; Division of Structural Biology, Wellcome Trust Centre of Human Genomics, 7 Roosevelt Drive, Oxford, OX3 7BN, United Kingdom; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Didcot, OX11 0QS, United Kingdom., Mourez M; Evotec, 40 Avenue Tony Garnier, 69007, Lyon, France., Bacqué E; Evotec, 1541, Avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Björkling F; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100, Denmark., Sabuco JF; Evotec, 1541, Avenue Marcel Mérieux, 69280, Marcy L'Etoile, France., Franzyk H; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100, Denmark.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Feb 05; Vol. 265, pp. 116097. Date of Electronic Publication: 2023 Dec 23.

LINGARD: I GOT A KICK-START FROM WEST HAM SPELL.

Autor: Dan Kilpatrick

Publikováno v: Evening Standard. 10/7/2021, p34. 1p.

A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state.

Autor: Schnapp G; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Neubauer H; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Büttner FH; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Handschuh S; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Lingard I; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany.; Aptuit (Verona) Srl, an Evotec Company, Via Alessandro Fleming, 4, 37135, Verona, Italy., Heilker R; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Klinder K; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Prestle J; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Walter R; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Wolff M; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Zeeb M; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Debaene F; NovAliX, BioParc, 850 bld Sebastien Brant, 67400, Illkirch, France., Nar H; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany., Fiegen D; Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach, Germany. dennis.fiegen@boehringer-ingelheim.com.

Publikováno v: Communications chemistry [Commun Chem] 2020 Jun 10; Vol. 3 (1), pp. 75. Date of Electronic Publication: 2020 Jun 10.