Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ling-shiang Chuang"'
Autor:
Ling-shiang Chuang
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 6 (2020)
The outbreak of COVID-19 has stalled both the basic, clinical and non-COVID medical research. The scientific community has shown extraordinary flexibility and resilience in responding to the pandemic. However, funding restructuring, risk of infection
Externí odkaz:
https://doaj.org/article/0b153f34b9b7451fa51f26aba17e5ce0
Autor:
Ling-shiang Chuang, Joshua Morrison, Nai-yun Hsu, Philippe Ronel Labrias, Shikha Nayar, Ernie Chen, Nicole Villaverde, Jody Ann Facey, Gilles Boschetti, Mamta Giri, Mireia Castillo-Martin, Tin Htwe Thin, Yashoda Sharma, Jaime Chu, Judy H. Cho
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 8 (2019)
Genome-wide association studies have identified over 200 genomic loci associated with inflammatory bowel disease (IBD). High-effect risk alleles define key roles for genes involved in bacterial response and innate defense. More high-throughput in viv
Externí odkaz:
https://doaj.org/article/92af79db91ab40a9b37d8885cb233256
Autor:
Nai-Yun Hsu, Shikha Nayar, Kyle Gettler, Sayali Talware, Mamta Giri, Isaac Alter, Carmen Argmann, Ksenija Sabic, Tin Htwe Thin, Huai-Bin Mabel Ko, Robert Werner, Christopher Tastad, Thaddeus Stappenbeck, Aline Azabdaftari, Holm H Uhlig, Ling-Shiang Chuang, Judy H Cho
Publikováno v:
Gut. 72:654-662
ObjectiveLoss-of-function mutations in genes generating reactive oxygen species (ROS), such asNOX1, are associated with IBD. Mechanisms whereby loss of ROS drive IBD are incompletely defined.DesignROS measurements and single-cell transcriptomics were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3794512a82bc2d3ab0402bd464bd3a78
https://doi.org/10.1136/gutjnl-2021-326305
https://doi.org/10.1136/gutjnl-2021-326305
Autor:
David R. Mack, Jarod Prince, Susan S. Baker, Brendan M. Boyle, Rebekah Karns, Suresh Venkateswaran, Subra Kugathasan, Talin Haritunians, Dermot P.B. McGovern, Mamta Giri, James Markowitz, Nai Yun Hsu, Melvin B. Heyman, Lee A. Denson, Ling-Shiang Chuang, Mayte Suárez-Fariñas, Greg Gibson, Jeffrey S. Hyams, Neal S. LeLeiko, Andrew Kasarskis, Kyle Gettler, Bruce J. Aronow, Cary G. Sauer, Yael Haberman, Carmen Argmann, Anne M. Griffiths, Joel R. Rosh, Nathan Gotman, Angela Mo, Dalia Arafat, Sapana Shah, Paul A. Rufo, Thomas D. Walters, Marian Pfefferkorn, Ashish S. Patel, Sonia Davis Thomas, Judy H. Cho, Robert N. Baldassano, Emebet Mengesha, Joshua D. Noe, Sini Nagpal
Publikováno v:
Am J Hum Genet
American journal of human genetics, vol 108, iss 9
American journal of human genetics, vol 108, iss 9
Summary An important goal of clinical genomics is to be able to estimate the risk of adverse disease outcomes. Between 5% and 10% of individuals with ulcerative colitis (UC) require colectomy within 5 years of diagnosis, but polygenic risk scores (PR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429feea2ec8be9ff6bb9b91aa2d58c90
https://doi.org/10.1016/j.ajhg.2021.07.013
https://doi.org/10.1016/j.ajhg.2021.07.013
Autor:
Yuval Itan, Mark S. Silverberg, Steven R. Brant, Ujunwa M. Korie, Aayushee Jain, Inga Peter, Shikha Nayar, Ling-Shiang Chuang, Talin Haritunians, Ksenija Sabic, John D. Rioux, Gerardus Bongers, Nicole Villaverde, Colleen C. Chasteau, Arden Moscati, Richard H. Duerr, Ernie Chen, Nai Yun Hsu, Tin Htwe Thin, Judy H. Cho, Sari Joshowitz, Isaac L. Alter, Siarhei Dzedzik, Zhi Chai, Mamta Giri, Kyle Gettler, L. Philip Schumm, Dermot P.B. McGovern
Publikováno v:
Gastroenterology
Background & Aims Recent literature has implicated a key role for mast cells in murine models of colonic inflammation, but their role in human ulcerative colitis (UC) is not well established. A major advance has been the identification of mrgprb2 (hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3908191a481e932c669d35df88240a
https://doi.org/10.1053/j.gastro.2020.12.076
https://doi.org/10.1053/j.gastro.2020.12.076
Autor:
Nai-Yun Hsu, Nayar, Shikha, Gettler, Kyle, Talware, Sayali, Giri, Mamta, Alter, Isaac, Argmann, Carmen, Sabic, Ksenija, Tin Htwe Thin, Huai-Bin Mabel Ko, Werner, Robert, Tastad, Christopher, Stappenbeck, Thaddeus, Azabdaftari, Aline, Uhlig, Holm H., Ling-Shiang Chuang, Cho, Judy H.
Publikováno v:
Gut; Apr2023, Vol. 72 Issue 4, p654-662, 9p
Autor:
Miriam Merad, Ling-Shiang Chuang, Ujunwa M. Korie, Renee M. Laird, Joana Gaifem, Jerome Martin, Jean-Frederic Colombel, Romain Remark, Salomé S. Pinho, Vanessa Barcessat, Hsin-Hui Huang, Chad K. Porter, Rok-Seon Choung, Diane Marie Del Valle, Siu Ling Tai, Judy H. Cho, Yeray Arteaga Jerez, Takahiro Sato, Catarina C. Azevedo, Nicole Villaverde, Arthur Mortha, Adeeb Rahman, Scot Plevy, Mona D. Wang, Zhi Chai, Joseph A. Murray, Ephraim Kenigsberg, Mark S. Riddle, Sacha Gnjatic, Gilles Boschetti, Kevin Tuballes, Inês Alves, Ilaria Laface, Joana Torres
Background & AimsAnti–GM-CSF autoantibodies (aGMAb) are detected in ileal Crohn’s Disease (CD) patients. Their induction and mode of action impacting homeostasis during, or prior to disease are not well understood. We aimed to investigate the und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75daa70150a822593596e873862c3e37
https://doi.org/10.1101/2021.08.23.21262143
https://doi.org/10.1101/2021.08.23.21262143
Autor:
Arthur Mortha, Romain Remark, Diane Marie Del Valle, Ling-Shiang Chuang, Zhi Chai, Inês Alves, Catarina Azevedo, Joana Gaifem, Jerome Martin, Francesca Petralia, Kevin Tuballes, Vanessa Barcessat, Siu Ling Tai, Hsin-Hui Huang, Ilaria Laface, Yeray Arteaga Jerez, Gilles Boschetti, Nicole Villaverde, Mona D. Wang, Ujunwa M. Korie, Joseph Murray, Rok-Seon Choung, Takahiro Sato, Renee M. Laird, Scott Plevy, Adeeb Rahman, Joana Torres, Chad Porter, Mark S. Riddle, Ephraim Kenigsberg, Salomé S. Pinho, Judy H. Cho, Miriam Merad, Jean-Frederic Colombel, Sacha Gnjatic
Publikováno v:
Gastroenterology. 163(3)
Anti-granulocyte macrophage-colony stimulating factor autoantibodies (aGMAbs) are detected in patients with ileal Crohn's disease (CD). Their induction and mode of action during or before disease are not well understood. We aimed to investigate the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36adef9aa98523d25231d2cab7068790
https://pubmed.ncbi.nlm.nih.gov/35623454
https://pubmed.ncbi.nlm.nih.gov/35623454
Autor:
Judy H. Cho, Ephraim Kenigsberg, Wallace Crandall, Ling-Shiang Chuang, Subra Kugathasan, Clara Abraham, Lee A. Denson, Joshua D. Noe, Nai Yun Hsu, Anne M. Griffiths, Jeffrey S. Hyams, Kyle Gettler, Mamta Giri, Richard Kellermayer, Jerome Martin, David R. Mack, Gabriel E. Hoffman
Publikováno v:
Genes & Immunity. 20:577-588
Genome-wide association studies have identified ~170 loci associated with Crohn's disease (CD) and defining which genes drive these association signals is a major challenge. The primary aim of this study was to define which CD locus genes are most li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da080b6e4bd3ba35e29690c89ea65c0a
https://doi.org/10.1038/s41435-019-0059-y
https://doi.org/10.1038/s41435-019-0059-y
Autor:
Suresh Venkateswaran, Melvin B. Heyman, Neal S. LeLeiko, Judy H. Cho, Robert N. Baldassano, T Walters, Ashish S. Patel, Brendan M. Boyle, Andrew Kasarskis, Ling-Shiang Chuang, Emebet Mengesha, Greg Gibson, Talin Haritunians, Nai Yun Hsu, Joshua D. Noe, Cary G. Sauer, David R. Mack, Yael Haberman, Jarod Prince, Susan S. Baker, Marian Pfefferkorn, Sini Nagpal, Mayte Suárez-Fariñas, Subra Kugathasan, Lee A. Denson, Anne M. Griffiths, James Markowitz, Bruce J. Aronow, Dalia Arafat, Sonia Davis Thomas, Rebekah Karns, Joel R. Rosh, Nathan Gotman, Angela Mo, Sapana Shah, Paul A. Rufo, Mamta Giri, Kyle Gettler, Dermot P.B. McGovern, Jeffrey S. Hyams, Carmen Argmann
SUMMARYAn important goal of clinical genomics is to be able to estimate the risk of adverse disease outcomes. Between 5% and 10% of ulcerative colitis (UC) patients require colectomy within five years of diagnosis, but polygenic risk scores (PRS) uti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d09708dd0049da6779a9a066af671465
https://doi.org/10.1101/2021.04.02.438187
https://doi.org/10.1101/2021.04.02.438187