Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Ling-chun Chen"'
Autor:
Ling-Chun Chen, Shyr-Yi Lin, Wei-Jie Cheng, Ming-Thau Sheu, Chi-Yun Chung, Chen-Hsuan Hsu, Hong-Liang Lin
Publikováno v:
Drug Delivery, Vol 30, Iss 1 (2023)
AbstractThe purpose of this study was to develop poloxamer (P407)-based in-situ thermogellable hydrogels with reducing concentration of P407 by adding hypromellose (HPMC) and with enhancing mucoadhesion of resulting hydrogels by adding hyaluronic aci
Externí odkaz:
https://doaj.org/article/4a6e12f80e3246beb05825779558c810
Autor:
Chien-Ju Lin, Hong-Liang Lin, Wen-Chen You, Hsiu-O Ho, Ming-Thau Sheu, Ling-Chun Chen, Wei-Jie Cheng
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 8, p 423 (2023)
In this study, an ultrasound-assisted digestion method of a formic acid-decellularized extracellular matrix (dECM) of porcine skin was developed and optimized to form UdECM hydrogels for diabetic wound healing. Results demonstrated that ultrasonicati
Externí odkaz:
https://doaj.org/article/822ebb3c26de438b84c688d41301e57a
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1428 (2023)
Sangelose® (SGL) is a novel hydroxypropyl methylcellulose (HPMC) derivative that has been hydrophobically modified. Due to its high viscosity, SGL has the potential as a gel-forming and release-rate-controlled material for application in swellable a
Externí odkaz:
https://doaj.org/article/23356994b37f48439f895582a298a6df
Autor:
Ling-Chun Chen, Wei-Jie Cheng, Shyr-Yi Lin, Ming-Tse Hung, Ming-Thau Sheu, Hong-Liang Lin, Chien-Ming Hsieh
Publikováno v:
Drug Delivery, Vol 28, Iss 1, Pp 2205-2217 (2021)
Therapeutic efficacies of orally administrated hydrophobic chemodrugs are decreased by poor water solubilities and reduced oral bioavailabilities by P-glycoprotein (P-gp) and CYP450. In this study, CPT11 alone or combined with dual-function inhibitor
Externí odkaz:
https://doaj.org/article/60fba43b184147e68b3468e03e99b7c1
Autor:
Yu-Hsuan Liu, Ling-Chun Chen, Wen-Ting Cheng, Pu-Sheng Wei, Chien-Ming Hsieh, Ming-Thau Sheu, Shyr-Yi Lin, Hsiu-O Ho, Hong-Liang Lin
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 473 (2023)
In recent years, combining different types of therapy has emerged as an advanced strategy for cancer treatment. In these combination therapies, oral delivery of anticancer drugs is more convenient and compliant. This study developed an irinotecan/rap
Externí odkaz:
https://doaj.org/article/00f9819882f5406098df3f61eed0e1a9
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 13, Iss 3, Pp 212-219 (2018)
Three thermal analytical techniques such as differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA) using five heating rates, and DSC-Fourier Transform Infrared (DSC-FTIR) microspectroscopy using one heating rate, were used to det
Externí odkaz:
https://doaj.org/article/71edd335886f4d3d81b8ffe8e36a02be
Autor:
Chia-En Chang, Chien-Ming Hsieh, Ling-Chun Chen, Chia-Yu Su, Der-Zen Liu, Hua-Jing Jhan, Hsiu-O Ho, Ming-Thau Sheu
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 632-643 (2018)
The synergistic combination of docetaxel (DTX) and cisplatin (CIS) by local drug delivery with a pluronic lecithin organogel (PLO) to facilitate high drug concentrations at tumor sites and less nonspecific distribution to normal organs is thought to
Externí odkaz:
https://doaj.org/article/efe77688b05d48be8190a9703af79528
Autor:
Chia-Yu Su, Michael Chen, Ling-Chun Chen, Yuan-Soon Ho, Hsiu-O Ho, Shyr-Yi Lin, Kuo-Hsiang Chuang, Ming-Thau Sheu
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 1066-1079 (2018)
Anti-mPEG/anti-human epidermal growth factor receptor 2 (HER2) bispecific antibodies (BsAbs) non-covalently bound to a docetaxel (DTX)-loaded mPEGylated lecithin-stabilized micellar drug delivery system (LsbMDDs) were endowed with active targetabilit
Externí odkaz:
https://doaj.org/article/3e809089fd6245a5b750eddb34f563c4
Autor:
Yusuke Miyazaki, Kota Mizumoto, Gautam Dey, Takamasa Kudo, John Perrino, Ling-chun Chen, Tobias Meyer, Thomas J. Wandless
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Protein aggregates are associated with a wide variety of diseases. Here, in order to address how protein aggregation affects cellular homoeostasis, the authors describe a method to rapidly create protein aggregates in living cells and organisms with
Externí odkaz:
https://doaj.org/article/bd34eaa0d4884eaaa320017ac28b1ea0
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 137 (2020)
Regarding compliance and minimization of side effects of nilotinib therapy, there is a medical need to have a gastroretentive drug delivery system (GRDDS) to enhance the oral bioavailability that is able to administer an optimal dose in a quaque die
Externí odkaz:
https://doaj.org/article/2b40aa9ab304413f9290d0fa7b23c714