Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ling-Wa Chong"'
Autor:
Ling-Wa Chong, S. M. Bukola Obayomi, Annette R. Atkins, Zong Wei, Ruth T. Yu, Liu Wang, Tae Gyu Oh, Gabriela Estepa, Jason A. Magida, Diana C. Hargreaves, Michael Downes, Jovylyn Gatchalian, Ronald M. Evans
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Glucocorticoids are widely prescribed antiinflammatory drugs that suppress inflammatory gene expression through activation of the glucocorticoid receptor (GR); however, the mechanisms of GR-mediated repression are not fully understood. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b061dd79bdb5a704f0aaf00e9b87a1
https://pubmed.ncbi.nlm.nih.gov/34446564
https://pubmed.ncbi.nlm.nih.gov/34446564
Autor:
Verena M. Link, Martina P. Pasillas, Zhengyu Ouyang, Joseph L. Witztum, Christopher K. Glass, Xiaoli Sun, Anita Gola, Mojgan Hosseini, Hunter Bennett, Ty D. Troutman, David Gosselin, Mashito Sakai, Jeffrey G. McDonald, Jason S. Seidman, Kaori M. Ego, Cassi M. Bruni, BaoChau T. Vu, Ling-Wa Chong, Ronald N. Germain, Ronald M. Evans, Bonne M. Thompson, Nathanael J. Spann, Rick Z. Li
Publikováno v:
SSRN Electronic Journal.
Tissue resident macrophages and recruited monocyte-derived macrophages contribute to host defense but also play pathological roles in a diverse range of human diseases. Multiple macrophage phenotypes are often represented in a diseased tissue, but we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ac6ae818d394c133aac7d193aa3d25f
https://doi.org/10.2139/ssrn.3541367
https://doi.org/10.2139/ssrn.3541367
Autor:
Liu Wang, Tae Gyu Oh, Magida, Jason, Estepa, Gabriela, Obayomi, S. M. Bukola, Ling-Wa Chong, Gatchalian, Jovylyn, Yu, Ruth T., Atkins, Annette R., Hargreaves, Diana, Downes, Michael, Zong Wei, Evans, Ronald M.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 8/31/2021, Vol. 118 Issue 35, p1-9, 9p
Autor:
Rick Z. Li, Ronald M. Evans, David Gosselin, Ty D. Troutman, Nathanael J. Spann, Martina P. Pasillas, Mojgan Hosseini, Bonne M. Thompson, Hunter Bennett, Verena M. Link, Zhengyu Ouyang, Jeffrey G. McDonald, Ronald N. Germain, Bao Chau T. Vu, Kaori M. Ego, Anita Gola, Mashito Sakai, Xiaoli Sun, Cassi M. Bruni, Ling Wa Chong, Jason S. Seidman, Christopher K. Glass, Joseph L. Witztum
Publikováno v:
Immunity, vol 52, iss 6
Immunity
Immunity
Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep understanding of mechanisms controlling diversification. Here, we investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b26572f341494c60eb8695f7b7d03ef
https://doi.org/10.1016/j.immuni.2020.04.001
https://doi.org/10.1016/j.immuni.2020.04.001
Autor:
Lauren A. Mack, Christopher Liddle, Sigal Gery, Zhengshan Chen, Qi Cao, Henry Yang, Xianping Shi, Xuan Zhao, Haibo Sun, De-Chen Lin, Qi Chen, Jonathan W. Said, Serhan Alkan, Jing-Wen Bai, Ruishu Deng, Ling Wa Chong, Markus Müschen, Michael Downes, Ronald M. Evans, Jian-Jun Xie, Han Cho, Ruth T. Yu, Annette R. Atkins, Ye Zheng, Quan Zhen Li, H. Phillip Koeffler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 47
The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [Cry double knockout (DKO)] develop an autoimmune phenotype including high serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec83e67eefb01b297a9051e42544974f
https://escholarship.org/uc/item/6wn972xv
https://escholarship.org/uc/item/6wn972xv
Publikováno v:
Nature Medicine. Dec2007, Vol. 13 Issue 12, p1496-1503. 8p. 4 Graphs.
Autor:
Michael Downes, Xuan Zhao, Xuemei Han, Christopher Liddle, Ronald M. Evans, Ling-Wa Chong, Katja A. Lamia, Han Cho, Tsuyoshi Hirota, Ruth T. Yu, Annette R. Atkins, Ester Banayo, Sihao Liu, John R. Yates, Steve A. Kay
Defects in circadian rhythm influence physiology and behavior with implications for the treatment of sleep disorders, metabolic disease, and cancer. Although core regulatory components of clock rhythmicity have been defined, insight into the mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8a6b5bd025db2bfd7767a1a11b2ffa
https://europepmc.org/articles/PMC4912445/
https://europepmc.org/articles/PMC4912445/
Autor:
Ling Wa Chong, Grant D. Barish, Michael T. Lam, Michael Downes, Annette R. Atkins, Christopher Liddle, Christopher K. Glass, Xuan Zhao, Ruth T. Yu, Luciano DiTacchio, Johan Auwerx, Megumi Hatori, Satchidananda Panda, Han Cho, Ronald M. Evans
Publikováno v:
Nature
The circadian clock acts at the genomic level to coordinate internal behavioural and physiological rhythms via the CLOCK-BMAL1 transcriptional heterodimer. Although the nuclear receptors REV-ERB-α and REV-ERB-β have been proposed to form an accesso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fed54f53feb6eeff91b01b1cabad70
http://europepmc.org/articles/PMC3367514
http://europepmc.org/articles/PMC3367514
Autor:
Linda K. Curtiss, Michael Downes, Chih-Hao Lee, Hoosang Hwang, Yuhua Zou, Annette R. Atkins, Peter Olson, Heonjoong Kang, Ronald M. Evans, Michael C. Nelson, Grant D. Barish, Ling Wa Chong
Publikováno v:
Proceedings of the National Academy of Sciences. 105:4271-4276
Lipid homeostasis and inflammation are key determinants in atherogenesis, exemplified by the requirement of lipid-laden, foam cell macrophages for atherosclerotic lesion formation. Although the nuclear receptor PPARδ has been implicated in both syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce57b197e8ed73a3df7617a377d349e
https://doi.org/10.1073/pnas.0711875105
https://doi.org/10.1073/pnas.0711875105
Autor:
Xiangli Li, Vincent Giguère, Ling Wa Chong, Josée Laganière, Chih-Hao Lee, Isaac R. Mehl, Alain R. Bataille, Ronald M. Evans, Immo E. Scheffler, Grant D. Barish, Dennis Mock, François Robert, Junichiro Sonoda
Publikováno v:
Genes & Development. 21:1909-1920
Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature of the IFN-gamma-induced activation pathway is not known. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0882171aaaba4d8c4d55c81b82639dd5
https://doi.org/10.1101/gad.1553007
https://doi.org/10.1101/gad.1553007