Zobrazeno 1 - 10
of 254
pro vyhledávání: '"Ling-Ling Zhu"'
Autor:
Qianqian Ruan, Yanan Geng, Ming Zhao, Heyang Zhang, Xiang Cheng, Tong Zhao, Xiangpei Yue, Xiufang Jiang, Xiaoxia Jiang, Xiao-Yu Hou, Ling-Ling Zhu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116342- (2024)
Background: Neuroinflammation is responsible for neuropsychiatric dysfunction following acute brain injury and neurodegenerative diseases. This study describes how a hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor FG-4592 prevents the
Externí odkaz:
https://doaj.org/article/79663c729a544d91a126156b8bef1ee5
Autor:
Yun-Ling He, Jian Li, Sheng-Hui Gong, Xiang Cheng, Ming Zhao, Yan Cao, Tong Zhao, Yong-Qi Zhao, Ming Fan, Hai-Tao Wu, Ling-Ling Zhu, Li-Ying Wu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-13 (2022)
Abstract Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria. BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3), a mitochondrial outer
Externí odkaz:
https://doaj.org/article/24a801bcbed540168f11f3ddd665ae64
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e18224- (2023)
Background: Folic acid and zinc supplements have been used to treat male infertility, but their efficacy is still debated. Objective: To systematically evaluate the effects of folic acid and folic acid plus zinc supplements on sperm characteristics a
Externí odkaz:
https://doaj.org/article/2b89c508bded483d943eef9cc18f35c6
Publikováno v:
Therapeutic Advances in Endocrinology and Metabolism, Vol 13 (2022)
Purpose: The aim of the study was to explore the correlation between serum vitamin B12 levels and glycemic fluctuation in patients with type 2 diabetes mellitus (T2DM). Methods: This study included 202 T2DM patients in whom blood glucose levels were
Externí odkaz:
https://doaj.org/article/e23a45425b9f4349b52b1a9c26f74c71
Autor:
Yan-Hong Li, Ke Wen, Ling-Ling Zhu, Sheng-Kai Lv, Qing Cao, Qian Li, Libin Deng, Tingtao Chen, Xiaolei Wang, Ke-Yu Deng, Ling-Fang Wang, Hong-Bo Xin
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Macrophage migration inhibitory factor (MIF) has multiple intrinsic enzymatic activities of the dopachrome/phenylpyruvate tautomerase and thiol protein oxidoreductase, and plays an important role in the development of obesity as a pro-inflammatory cy
Externí odkaz:
https://doaj.org/article/2ebd5684290e4906b4ffe378621aacf4
Autor:
Li-Li Liu, Dahu Li, Yun-Ling He, Yan-Zhao Zhou, Sheng-Hui Gong, Li-Ying Wu, Yong-Qi Zhao, Xin Huang, Tong Zhao, Lun Xu, Kui-Wu Wu, Ming-Gao Li, Ling-Ling Zhu, Ming Fan
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 258-271 (2017)
Abstract The kidney is vulnerable to hypoxia-induced injury. One of the mechanisms underlying this phenomenon is cell apoptosis triggered by hypoxia-inducible factor-1- α (HIF-1α) activation. MicroRNA-210 (miR-210) is known to be induced by HIF-1α
Externí odkaz:
https://doaj.org/article/2c5146324d944641ae76ab2db3156064
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Hypoxia is the most critical factor for maintaining stemness. During embryonic development, neural stem cells (NSCs) reside in hypoxic niches, and different levels of oxygen pressure and time of hypoxia exposure play important roles in the developmen
Externí odkaz:
https://doaj.org/article/bbcc6690219446f795d3de86b8b8f1ca
Publikováno v:
Neurobiology of Disease, Vol 64, Iss , Pp 66-78 (2014)
Notch1 is a transcription factor on the membrane and regulates various stages of neurogenesis. Recently, studies have shown that in vitro neurogenesis is enhanced by hypoxia, and there is cross-coupling between Notch and hypoxia signaling pathways in
Externí odkaz:
https://doaj.org/article/863ca7bb32fa40b28650569ebe147866
Autor:
Ling-Ling Zhu, Jay Cao, Merry Sun, Tony Yuen, Raymond Zhou, Jianhua Li, Yuanzhen Peng, Surinder S Moonga, Lida Guo, Jeffrey I Mechanick, Jameel Iqbal, Liu Peng, Harry C Blair, Zhuan Bian, Mone Zaidi
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47058 (2012)
Epidemiologic studies correlate low vitamin C intake with bone loss. The genetic deletion of enzymes involved in de novo vitamin C synthesis in mice, likewise, causes severe osteoporosis. However, very few studies have evaluated a protective role of
Externí odkaz:
https://doaj.org/article/a01bbb06578c4d37ba9067dcb4e230fb
Autor:
Ying Zhang, Ming Zhao, Cheng‐Bo Wang, Yu Wang, Stanislas Nsanzamahoro, Ling‐Ling Zhu, Wei‐Feng Wang, Jun‐Li Yang
Publikováno v:
ELECTROPHORESIS. 43:1601-1610
Prolyl hydroxylase domain 2 (PHD2) is a key enzyme regulating the expression of hypoxia inducible factor (HIF). Its inhibitors can improve the expression of HIF and downstream genes, which can treat hypoxia-related diseases. Therefore, the establishm