Temporal changes in gut microbiota profile in children with acute lymphoblastic leukemia prior to commencement-, during-, and post-cessation of chemotherapy

Autor: Ling Ling Chua, Reena Rajasuriar, Yvonne Ai Lian Lim, Yin Ling Woo, P’ng Loke, Hany Ariffin

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)

Abstract Background Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether the perturbed microbiota community is restored after disease remission and cessation of cancer treatment has not be

Externí odkaz: https://doaj.org/article/1368d38f92d841d5a529a71ea029b41e

Identification of Targets from LRRK2 Rescue Phenotypes

Autor: Joanne Toh, Ling Ling Chua, Patrick Ho, Edwin Sandanaraj, Carol Tang, Hongyan Wang, Eng King Tan

Publikováno v: Cells, Vol 10, Iss 1, p 76 (2021)

Parkinson’s disease (PD) is an age-dependent neurodegenerative condition. Leucine-rich repeat kinase 2 (LRRK2) mutations are the most frequent cause of sporadic and autosomal dominant PD. The exact role of LRRK2 protective variants (R1398H, N551K)

Externí odkaz: https://doaj.org/article/6f6d4e20230f45c4b9a82332ef5571e1

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Autor: Ling Ling Chua, Peter Heeringa, Kirill Tsyganov, Mirjan M. van Timmeren, Coen A. Stegeman, Yong Zhong, Joshua D. Ooi, Hugh H. Reid, Jamie Rossjohn, A. Richard Kitching, Jhih-Hang Jiang, Poh Y. Gan, Lani Shochet, Stephen R. Holdsworth, Jessica Ryan, Peter J. Eggenhuizen, Kim M. O’Sullivan, Lars Fugger, Khai Lee Loh, Anton Y. Peleg

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 10(1):3392. Nature Publishing Group
Nature Communications
Ooi, J D, Jiang, J-H, Eggenhuizen, P J, Chua, L L, van Timmeren, M, Loh, K L, O'Sullivan, K M, Gan, P Y, Zhong, Y, Tsyganov, K, Shochet, L R, Ryan, J, Stegeman, C A, Fugger, L, Reid, H H, Rossjohn, J, Heeringa, P, Holdsworth, S R, Peleg, A Y & Kitching, A R 2019, ' A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity ', Nature Communications, vol. 10, no. 1, pp. 3392 . https://doi.org/10.1038/s41467-019-11255-0

Autoreactivity to myeloperoxidase (MPO) causes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with rapidly progressive glomerulonephritis. Here, we show that a Staphylococcus aureus peptide, homologous to an immunodominant M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4a62d2d45fd6ad2b22f862b3837244
http://link.springer.com/article/10.1038/s41467-019-11255-0

Retinal vessel analysis as a novel screening tool to identify childhood acute lymphoblastic leukemia survivors at risk of cardiovascular disease

Autor: Sudhashini Chandrasekaran, Tom MacGillivray, Rosli Es, Ling Ling Chua, Mohamad Shafiq Azanan, Hany Ariffin, Lixian Oh, Tong Foh Chin, Tengku Ain Kamalden, Revathi Rajagopal, Norlina Ramli, Reena Rajasuriar, Tsiao Yi Yap, Emanuele Trucco

Publikováno v: Yearbook of Paediatric Endocrinology.

BACKGROUND Microvascular endothelial dysfunction is central to the pathogenesis of cardiovascular disease (CVD). The eye offers direct access for endothelial health assessment via the retinal microvasculature. The aim of the study was to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342fd699fd78e348a4ada578c2297f89
https://doi.org/10.1530/ey.17.9.11

Immunity in young adult survivors of childhood leukemia is similar to the elderly rather than age-matched controls: Role of cytomegalovirus

Autor: Sharon R Lewin, Hany Ariffin, Shahrul Bahyah Kamaruzzaman, Su Han Lum, Noor Kamila Abdullah, Reena Rajasuriar, Sayyidatul Syahirah Abdul Ghafar, Ling Ling Chua, Yin Ling Woo, Adeeba Kamarulzaman, Mohamad Shafiq Azanan

Publikováno v: European Journal of Immunology. 46:1715-1726

Many treatment complications that occur late in childhood cancer survivors resemble age-related comorbidities observed in the elderly. An immune phenotype characterized by increased immune activation, systemic inflammation, and accumulation of late-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67424e5593332147215777595d9f327
https://doi.org/10.1002/eji.201646356