Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ling-Li Gao"'
Discovery of Potent and Novel Dual PARP/BRD4 Inhibitors for Efficient Treatment of Pancreatic Cancer
Autor:
Lei Huang, Qian-Wen Lin, Shuping Wang, Qihua Zhu, Qin Sun, Yungen Xu, Shi-Qi Wu, Shi-Hui Huang, Ling-Li Gao, Liu-Qiong Meng, Yi Zou, Yu Li
Publikováno v:
Journal of Medicinal Chemistry. 64:17413-17435
Targeting poly(ADP-ribose) polymerase1/2 (PARP1/2) is a promising strategy for the treatment of pancreatic cancer with breast cancer susceptibility gene (BRCA) mutation. Inducing the deficiency of homologous recombination (HR) repair is an effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d22c5fe6579643fc94e1bcf16d3612
https://doi.org/10.1021/acs.jmedchem.1c01535
https://doi.org/10.1021/acs.jmedchem.1c01535
Autor:
Shi-Hui Huang, Ran Cao, Qian-Wen Lin, Shi-Qi Wu, Ling-Li Gao, Qin Sun, Qi-Hua Zhu, Yi Zou, Yun-Gen Xu, Shu-Ping Wang
Publikováno v:
European Journal of Medicinal Chemistry. 230:114116
Inducing the deficiency of homologous recombination (HR) repair is an effective strategy to broaden the indication of PARP inhibitors in pancreatic cancer treatment. Repression of BRD4 has been reported to significantly elevate HR deficiency and sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cfb7188da7f5bd1792c208e705d7b9
https://doi.org/10.1016/j.ejmech.2022.114116
https://doi.org/10.1016/j.ejmech.2022.114116