Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ling-Jie Gao"'
Publikováno v:
Molecules, Vol 26, Iss 4, p 923 (2021)
Nucleoside and nucleotide analogues are essential antivirals in the treatment of infectious diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus (HSV), varicella-zoster virus (VZV
Externí odkaz:
https://doaj.org/article/e4ea8592b2f74782b39cf5b161e8d675
Autor:
Ling-Jie Gao, Gunther Van Cauwenberge, Noël Hosten, Dirk Van Haver, Magali Waelbroeck, Pierre J. De Clercq
Publikováno v:
ARKIVOC, Vol 2003, Iss 4, Pp 22-45 (2003)
Externí odkaz:
https://doaj.org/article/21507ec1744a401bb59e5d3d5eafc44e
Autor:
Joleen Masschelein, Wesley Mattheus, Ling-Jie Gao, Pieter Moons, Rob Van Houdt, Birgit Uytterhoeven, Chris Lamberigts, Eveline Lescrinier, Jef Rozenski, Piet Herdewijn, Abram Aertsen, Chris Michiels, Rob Lavigne
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54143 (2013)
Serratia plymuthica strain RVH1, initially isolated from an industrial food processing environment, displays potent antimicrobial activity towards a broad spectrum of Gram-positive and Gram-negative bacterial pathogens. Isolation and subsequent struc
Externí odkaz:
https://doaj.org/article/d276ab8c844a4082a283dce5fd4294b9
Autor:
Jozef Anné, Eveline-Marie Lammens, Piet Herdewijn, Thomas Lathouwers, Matthew P. Crump, Michiel Vanmeert, Harry Cuppens, Joleen Masschelein, Ruben Degroote, Eveline Lescrinier, Ling-Jie Gao, Rob Lavigne, Angus N M Weir, Simone Kosol, Thomas J. Simpson, Kristof Vrancken, Christine L. Willis, Christopher D. Fage
Publikováno v:
Fage, C D, Lathouwers, T, Vanmeert, M, Gao, L-J, Vrancken, K, Lammens, E-M, Weir, A N M, Degroote, R, Cuppens, H, Kosol, S, Simpson, T J, Crump, M P, Willis, C L, Herdewijn, P, Lescrinier, E, Lavigne, R, Anné, J & Masschelein, J 2020, ' The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI ', Angewandte Chemie-International Edition, vol. 59, no. 26, pp. 10549-10556 . https://doi.org/10.1002/anie.201915407
The enoyl-acyl carrier protein reductase enzyme FabI is essential for fatty acid biosynthesis in Staphylococcus aureus and represents a promising target for the development of novel, urgently needed anti-staphylococcal agents. Here, we elucidate the
Autor:
Rina Barouch-Bentov, Ling-Jie Gao, Piet Herdewijn, J.M. Elkins, Fiona J. Sorrell, Shirit Einav, Laura I. Prugar, Stefan Knapp, Steven De Jonghe, Jennifer M. Brannan, Danielle Dorosky, Mathy Froeyen, Sven Verdonck, John M. Dye, Szu-Yuan Pu
Publikováno v:
J Med Chem
There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine-threonine protein kinase that functions as a key regulator of the clathrin-associa
Publikováno v:
Molecules
Molecules, Vol 26, Iss 923, p 923 (2021)
Molecules, Vol 26, Iss 923, p 923 (2021)
Nucleoside and nucleotide analogues are essential antivirals in the treatment of infectious diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus (HSV), varicella-zoster virus (VZV
Autor:
Adnan Khan, Farnaz Fallah-Arani, Bart Vanderhoydonck, Judi Charlotte Neuss, Sarah Malcolm, Alfred Lammens, Richard J. Franklin, Lindsay K. Shuttleworth, Qiuya Huang, Jamie Henshall, Daniel James Ford, Mi-Yeon Jang, Shengqiao Li, Helen Tracey Horsley, Daniel Christopher Brookings, Mark Waer, Rodger A. Allen, Payne Andrew Charles, Yuan Lin, Eleanor Ward, Tom Ceska, Piet Herdewijn, Mark Jairaj, James Thomas Reuberson, Stefan Steinbacher, Mark Daniel Calmiano, Carl Brendan Doyle, Ling-Jie Gao, William R. Pitt, Jean Herman, Martin Augustin, Thierry Louat, Anant Ramrao Ghawalkar
Publikováno v:
Journal of medicinal chemistry. 61(15)
The primary target of a novel series of immunosuppressive 7-piperazin-1-ylthiazolo[5,4- d]pyrimidin-5-amines was identified as the lipid kinase, PI4KIIIβ. Evaluation of the series highlighted their poor solubility and unwanted off-target activities.
Autor:
Anna Teresa Ramadori, Piet Herdewijn, Sona Kovackova, Michal Sala, Ling-Jie Gao, Steven De Jonghe
Publikováno v:
Journal of Medicinal Chemistry. 57:7624-7643
DRAK2 emerged as a promising drug target for the treatment of autoimmune diseases and to prevent graft rejection after organ transplantation. Screening of a compound library in a DRAK2 binding assay led to the identification of an isothiazolo[5,4-b]p
Autor:
Anna Teresa Ramadori, Piet Herdewijn, Jef Rozenski, Ling-Jie Gao, Steven De Jonghe, Piotr Leonczak, Eveline Lescrinier
Publikováno v:
ChemMedChem. 9:2587-2601
In recent years, DAPK-related apoptosis-inducing protein kinase 2 (DRAK2) has emerged as a promising target for the treatment of a variety of autoimmune diseases and for the prevention of graft rejection after organ transplantation. However, medicina
Autor:
Roger G. Ptak, Piet Herdewijn, Chunsheng Huang, Munmun Maiti, Steven De Jonghe, Ling-Jie Gao, Michael G. Murray
Publikováno v:
Organicbiomolecular chemistry. 14(37)
In an attempt to identify novel nucleoside phosphoramidate analogues for improving the anti-HCV activity of 2’-C-Me-uridine, we have synthesized for the first time a series of L-glutamic acid, L-serine, L-threonine and L-tyrosine containing aryloxy