Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Ling-Jen Chen"'
1
Disposition and Metabolism of Cumene in F344 Rats and B6C3F1 Mice
Autor: Daniel J. Kramer, Ling-Jen Chen, J. Michael Sanders, Leslie A. Thomas, Jacob D. McDonald, Christopher J. Wegerski, Kelly J. Dix
Publikováno v: Drug Metabolism and Disposition. 39:498-509
Cumene is a high-production volume chemical that has been shown to be a central nervous system depressant and has been implicated as a long-term exposure carcinogen in experimental animals. The absorption, distribution, metabolism, and excretion of [
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb609aa38b84812e6a4a9440fa815a0
https://doi.org/10.1124/dmd.110.034769
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2
Chemical and Enzymatic Oxidation of Furosemide: Formation of Pyridinium Salts
Autor: Ling-Jen Chen, Leo T. Burka
Publikováno v: Chemical Research in Toxicology. 20:1741-1744
Furosemide (Lasix) is frequently used in the treatment of cardiovascular and renal disease. Only one metabolite, furosemide glucuronide, has ever been identified. Oxidation of furosemide by cytochrome P450 has been demonstrated, but the metabolite(s)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186b9a16cab54668cde559a66d3abd38
https://doi.org/10.1021/tx700262z
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3
14C-labeled Pulegone and Metabolites Binding to α2u-globulin in Kidneys of Male F-344 Rats∗
Autor: Fred B. Lih, Ling-Jen Chen Ferguson, Edward H. Lebetkin, Horace D. Parkinson, Kenneth B. Tomer, Leo T Burka, Susan J. Borghoff
Publikováno v: Journal of Toxicology and Environmental Health, Part A. 70:1416-1423
Pulegone is a major constituent of pennyroyal oil and a minor component of peppermint oil. Pulegone is biotransformed to menthofuran and menthones (diastereomeric menthone and isomenthone) in pennyroyal and peppermint as well as in rodents. Pulegone
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8ec7ea333b2b509b9775b6663dfa3f
https://doi.org/10.1080/15287390701382720
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4
DISPOSITION OF 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5 H )-FURANONE (MX) IN B6C3F1 MICE AND F344 RATS
Autor: Leo T. Burka, Ling-Jen Chen, Edward H. Lebetkin
Publikováno v: Journal of Toxicology and Environmental Health, Part A. 65:2101-2118
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) is a mutagenic by-product of chlorination of drinking water, particularly where the water contains humic matter. MX has been estimated to account for 50% of the mutagenic activity in some drin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3aab05b1921eb3208dad0db8d1806af
https://doi.org/10.1080/00984100290071522
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6
Formation of o-nitrosobenzaldehyde from hydrolysis of o-nitrobenzyl tosylate. Evidence of intramolecular nucleophilic interaction
Autor: Leo T. Burka, Ling-Jen Chen
Publikováno v: Tetrahedron Letters. 39:5351-5354
Hydrolysis of o -nitrobenzyl tosylate in CH 3 CN:H 2 O (1:1, v/v) gave o -nitrobenzyl alcohol and o -nitrosobenzaldehyde in 1.8:1 ratio. Formation of o -nitrosobenzaldehyde indicates that the nitro group participates in the leaving of the tosylate gr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a37e00645ac84496ecde2f8d449e45aa
https://doi.org/10.1016/s0040-4039(98)01068-5
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7
Intermolecular Electron-Transfer Reactions Involving Hydrazines
Autor: Douglas R. Powell, Ling-Jen Chen, Gilbert T. Voy, Stephen F. Nelsen, Michael T. Ramm, Troy R. Seehafer, Molly A. Accola, and Jobiah J. Sabelko, Jack R. Pladziewicz
Publikováno v: The Journal of Organic Chemistry. 61:1405-1412
The self-exchange electron-transfer (ET) rate constant k22 for 1,2,3,4,5-pentamethylferrocene was determined by NMR line broadening to be 8.5(±0.8) × 106 M-1 s-1 (25 °C, CD3CN/0.09 M Et4NBF4) and k11 for the bis-N,N-bicyclic hydrazine, 9,9‘-bi-9
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44993e511dc05112aa7bf648262d1197
https://doi.org/10.1021/jo9510090
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9
ChemInform Abstract: Conformationally Protected Hydrazine Radical Cations and the Gearing Effect on a Hydrazine Electron-Transfer Reaction
Autor: Dennis H. Evans, Peter A. Petillo, Stephen F. Nelsen, Franz A. Neugebauer, Ling-Jen Chen
Publikováno v: ChemInform. 25
The N-isopropylated hydrazine radical cations from 7 (22/tBu,iPr) and 9 (22/iPr 2 ) are isolable and are the first examples of isolable hydrazine radical cations which lack all Ca-H bonds being protected as bridgehead carbons in bicyclic rings. The c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5756385f8a6957fa1433c89f9dd7041
https://doi.org/10.1002/chin.199408104
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10
Metabolism of furans in vitro: ipomeanine and 4-ipomeanol
Autor: Ling-Jen Chen, Eugene F. DeRose, Leo T. Burka
Publikováno v: Chemical research in toxicology. 19(10)
Ipomeanine (IPN), 4-ipomeanol (4-IPO), 1-ipomeanol (1-IPO), and 1,4-ipomeadiol (DIOL) are toxic 3-substituted furans found in mold-damaged sweet potatoes. IPN and 4-IPO are the most toxic, but all produce pulmonary toxicity in cattle and rodents, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79992a9331f63d0985961522b74d8cd3
https://pubmed.ncbi.nlm.nih.gov/17040101
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