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Long noncoding RNA Gas5 induces cell apoptosis and inhibits tumor growth via activating the CHOP‐dependent endoplasmic reticulum stress pathway in human hepatoblastoma HepG2 cells

Autor: Ming-Kai Li, Zhe Liu, Wei‑Yi Zhang, Guan-Di Wu, Hao-Lian Zhan, Ling-Fei Wu

Publikováno v: Journal of Cellular Biochemistry. 123:231-247

In recent years, long noncoding RNAs (lncRNAs) have been demonstrated to be important tumor-associated regulatory factors. LncRNA growth arrest-specific transcript 5 (Gas5) acts as an anti-oncogene in most cancers. Whether Gas5 acts as an oncogene or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e60b5ed8fb12a9500ec72b0181abad3
https://doi.org/10.1002/jcb.30159

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Long non-coding RNA MEG3 suppresses epithelial-to-mesenchymal transition by inhibiting the PSAT1-dependent GSK-3β/Snail signaling pathway in esophageal squamous cell carcinoma

Autor: Wei‑Yi Zhang, Jia‑Lin Feng, Li‑Xuan Liu, Hao‑Lian Zhan, Ming‑Kai Li, Ling‑Fei Wu, Rui‑Pei Chen

Publikováno v: Oncology Reports

Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer in China, and the prognosis of patients remains poor mainly due to the occurrence of lymph node and distant metastasis. The long non‑coding RNA (lncRNA) maternally e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7966f50fd4a49e520b9c8bd3c49b95
http://europepmc.org/articles/PMC7550985

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Estrogen induces IDO expression via TGF‑β in chorionic villi and decidua during early stages of pregnancy

Autor: Peifan Li, Fa Shun, Ling-Fei Wu, Guanyou Huang, Shuyun Zhao, Liping Yang, Yuanyuan Tu, Yuhong Weng, Jun Wang, Ziwen Xiao, Hua Zhou, Minyan Yang, Zhuo Chen

Publikováno v: International Journal of Molecular Medicine. 46:1186-1196

Indoleamine 2,3‑dioxygenase (IDO) is one of the most important proteins protecting the embryos from the mother's immune system during pregnancy; however, little is known about the regulation of expression of this protein at the maternal‑fetal int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170cb2a4701e250fe59d7684a2d0842b
https://doi.org/10.3892/ijmm.2020.4658

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Involvement of endoplasmic reticulum stress and p53 in lncRNA MEG3-induced human hepatoma HepG2 cell apoptosis

Autor: Meng‑Qi Xiang, Bin Liu, Ling‑Fei Wu, Li‑Xuan Liu, Jia‑Lin Feng, Zhen‑Lun Huang, Rui‑Pei Chen, Guo‑Ping Li

Publikováno v: Oncology Reports. 36:1649-1657

Long non-coding RNAs (lncRNAs) play important roles in diverse biological processes. Although downregulation of lncRNA maternally expressed gene 3 (MEG3) has been identified in several types of cancers, little is known concerning its biological role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6654ba878db4798944bf1d5d784832
https://doi.org/10.3892/or.2016.4919

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LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathway

Autor: Ling-Fei Wu, Li-Xuan Liu, Hui Tan, Xiao-Tao Zhou, Meng-Qi Xiang, Hao-Lian Zhan, Yi-Tian Guo, Guo-Ping Li, Ze-Jin Pu

Publikováno v: Journal of cellular biochemistry. 120(10)

Adenosine is a promising cytotoxic reagent for tumors, long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been indicated to play critical roles in tumorigenesis, ILF3 has been recognized as a MEG3-binding protein, however, the roles o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b955bd62fcfed2bc76f9b5d250b2376b
https://pubmed.ncbi.nlm.nih.gov/31144362

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The mechanism of adenosine-mediated activation of lncRNA MEG3 and its antitumor effects in human hepatoma cells

Autor: Ling-Fei Wu, Li-Xuan Liu, Yi-Tian Guo, Wei Deng, Rui-Pei Chen, Rui Li, Meng-Qi Xiang, Ge-Fei Wang, Xiao-Tao Zhou, Ze-Jin Pu

Publikováno v: International Journal of Oncology. 48:421-429

Long non-coding RNA MEG3 is suggested to function as a tumor suppressor. However, the activation mechanism of MEG3 is still not well understood and data are not available on its role under adenosine-induced apoptosis. In this study, HepG2 cells were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574383b9f4e514f0aaa57a686002fc24
https://doi.org/10.3892/ijo.2015.3248

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