Výsledky vyhledávání - "Ling Rong Wong"

Akademický článek

Chronic treatment with baicalein alleviates behavioural disorders and improves cerebral blood flow via reverting metabolic abnormalities in a J20 transgenic mouse model of Alzheimer's disease

Autor: Li Zhang, Ling Rong Wong, Peiyan Wong, Wanxiang Shen, Shili Yang, Lizhen Huang, Yun-An Lim, Paul Chi-Lui Ho

Publikováno v: Brain, Behavior, & Immunity - Health, Vol 28, Iss , Pp 100599- (2023)

Baicalein (BE) has both antioxidant and anti-inflammatory effects. It has also been reported able to improve cerebral blood circulation in brain ischemic injury. However, its chronic efficacy and metabolomics in Alzheimer's disease (AD) remain unknow

Externí odkaz: https://doaj.org/article/2bfa618cf8a04a70996465273b233727

Zobrazit plný text záznamu

Akademický článek

Metabolic Profiling of Female Tg2576 Mouse Brains Provides Novel Evidence Supporting Intranasal Low-Dose Pioglitazone for Long-Term Treatment at an Early Stage of Alzheimer’s Disease

Autor: Ling Rong Wong, Peiyan Wong, Paul Chi-Lui Ho

Publikováno v: Biomedicines, Vol 8, Iss 12, p 589 (2020)

Accumulating evidence suggests that disruptions in brain energy metabolism may be a key player in the pathogenesis of Alzheimer’s disease (AD). Pioglitazone (PIO) has been found to exert beneficial effects on metabolic dysfunction in many AD precli

Externí odkaz: https://doaj.org/article/38041ee853aa43c0bdc41e93b23cda55

Zobrazit plný text záznamu

In Vitro and In Vivo Comparison of Curcumin-Encapsulated Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles and Curcumin/Hydroxypropyl-β-Cyclodextrin Inclusion Complexes Administered Intranasally as Therapeutic Strategies for Alzheimer’s Disease

Autor: Li Zhang, Ling Rong Wong, Paul C. Ho, Hui Xie, Shili Yang

Publikováno v: Molecular Pharmaceutics. 17:4256-4269

Curcumin (CUR) has antioxidant and anti-inflammatory effects that are beneficial to Alzheimer's disease (AD). However, the poor solubility and high instability of CUR compromise its application greatly. In this study, CUR-encapsulated chitosan-coated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::609cd3f69320444cdf0cf77a26e788a0
https://doi.org/10.1021/acs.molpharmaceut.0c00675

Zobrazit plný text záznamu

Reverting Metabolic Dysfunction in Cortex and Cerebellum of APP/PS1 Mice, a Model for Alzheimer's Disease by Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Agonist

Autor: Shili Yang, Hai Ning Pee, Ling Rong Wong, Paul C. Ho, Kai Lun Chang

Publikováno v: Molecular neurobiology. 56(11)

Identification of molecular mechanisms underlying early-stage Alzheimer's disease (AD) is important for the development of new therapies against and diagnosis of AD. In this study, gas chromatography time-of-flight mass spectrometry (GC-TOF-MS)-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49e36d49374920574af93ec31f37309
https://pubmed.ncbi.nlm.nih.gov/31016475

Zobrazit plný text záznamu

Role of serum albumin as a nanoparticulate carrier for nose-to-brain delivery of R-flurbiprofen: implications for the treatment of Alzheimer's disease

Autor: Ling Rong Wong, Paul C. Ho

Publikováno v: The Journal of pharmacy and pharmacology. 70(1)

Objectives R-flurbiprofen (R-FP) was found to offer neuroprotective effects by inhibiting mitochondrial calcium overload induced by β-amyloid peptide toxicity in Alzheimer's disease (AD). However, poor brain penetration after oral administration pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedb5d1977cdc8e763bdcfb9bd42e192
https://pubmed.ncbi.nlm.nih.gov/29034965

Zobrazit plný text záznamu

Anagostic Interactions and Catalytic Activities of Sterically Bulky Benzannulated N-Heterocyclic Carbene Complexes of Nickel(II)

Autor: Han Vinh Huynh, Ling Rong Wong, Pearly Shuyi Ng

Publikováno v: Organometallics. 27:2231-2237

Nickel(II) bis(benzimidazolin-2-ylidene) complexes of the general formula [NiBr2(NHC)2] (NHC = 1,3-dibenzylbenzimidazolin-2-ylidene, 7; NHC = 1,3-diisopropylbenzimidazolin-2-ylidene, 8; NHC = 1,3-d...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f002ace4ad8a45fb5a514a358e9dcad
https://doi.org/10.1021/om800004j

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání