Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ling Hui Chou"'
Publikováno v:
Journal of Functional Foods, Vol 27, Iss , Pp 150-159 (2016)
The objectives of this study were to compare the anti-inflammatory effect of ethyl extract from micronized and nonmicronized luffa peels in BALB/c mice, and to analyse the functional components in both extracts. Results showed that the concentrations
Externí odkaz:
https://doaj.org/article/e16863365a4347648d7ad93b713e5887
Autor:
Hsing Pang Hsieh, Pei-Chen Wang, Wan-Ching Yen, Kun-Hung Lee, Yu-Chen Huang, Chun-Yu Chang, Yu-Chieh Su, Chen-Ming Yang, You-Liang Lai, Wen-Hsing Lin, Chiung-Tong Chen, Chuan Shih, Teng-Kuang Yeh, Ling-Hui Chou, Cai-Syuan Wu
Publikováno v:
Journal of Medicinal Chemistry. 64:14477-14497
Colony-stimulating factor-1 receptor (CSF1R) is implicated in tumor-associated macrophage (TAM) repolarization and has emerged as a promising target for cancer immunotherapy. Herein, we describe the discovery of orally active and selective CSF1R inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ca30e1530cdc6cc191b0eff08616e9
https://doi.org/10.1021/acs.jmedchem.1c01006
https://doi.org/10.1021/acs.jmedchem.1c01006
Autor:
Min-Hsien Wang, Tai-Yu Chiu, Teng-Kuang Yeh, Ching Ping Chen, Su-Wen Nieh, Chin-Yi Tsai, Chien Ho, Chiung-Tong Chen, Li Liu, Tsang-Wu Liu, Ying-Min Cheng, Ling-Hui Chou, Yen-Ju Chen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
A major obstacle to nanodrugs-mediated cancer therapy is their rapid uptake by the reticuloendothelial system that decreases the systemic exposure of the nanodrugs to tumors and also increases toxicities. Intralipid has been shown to reduce nano-oxal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6bc8bd3acc121cbbf45242b1177de2
http://link.springer.com/article/10.1038/s41598-020-59813-7
http://link.springer.com/article/10.1038/s41598-020-59813-7
Autor:
Hui-You Lin, Yi-Hui Peng, Kuo Wei Huang, Chen-Lung Huang, Mine-Hsine Wu, Chuan Shih, Teng-Kuang Yeh, Weir-Torn Jiaang, Ching-Chuan Kuo, Tsu Hsu, Ching-Ping Chen, Ya-Ling Weng, Chiung-Tong Chen, Fang-Chun Kung, Wen-Hsing Lin, Hui Yi Shiao, Jen-Shin Song, Ling-Hui Chou, Tsung-Sheng Wu, Kuei-Jung Yen, Pei-Chen Wang, Ching-Cheng Hsueh, Yu-Chieh Su, Cheng-Tai Lu, Hui-Jen Tsai, Su-Ying Wu, Li-Tzong Chen, Po-Chu Kuo
Publikováno v:
Journal of Medicinal Chemistry. 62:11135-11150
Gastrointestinal stromal tumors (GISTs) are prototypes of stem cell factor receptor (c-KIT)-driven cancer. Two receptor tyrosine kinases, c-KIT and fms-tyrosine kinase (FLT3), are frequently mutated in acute myeloid leukemia (AML) patients, and these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60499fc4136ddd2d5cf080a65b7dda3b
https://doi.org/10.1021/acs.jmedchem.9b01229
https://doi.org/10.1021/acs.jmedchem.9b01229
Autor:
Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang, Kuei-Jung Yen, Chun-Hwa Chen, Chin-Ting Huang, Shih-Chieh Yen, Shu-Yi Hsieh, Ling-Hui Chou, Ching-Ping Chen, Chun-Hsien Chiu, Li-Chun Kao, Yu-Sheng Chao, Chiung-Tong Chen, John T-A Hsu
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83160 (2014)
Overexpression or/and activating mutation of FLT3 kinase play a major driving role in the pathogenesis of acute myeloid leukemia (AML). Hence, pharmacologic inhibitors of FLT3 are of therapeutic potential for AML treatment. In this study, BPR1J-340 w
Externí odkaz:
https://doaj.org/article/e5078208d61149adbf9f92f8697b3132
Autor:
Kai-Chia Yeh, Min-Hsien Wang, Weir-Torn Jiaang, Chung-Yu Huang, Jen-Shin Song, Yu-Wen Huang, Chih-Bo Hu, Yu-Sheng Chao, Hsuan-Hui Ho, Chiung-Tong Chen, Tsu Hsu, Ling-Hui Chou, Teng-Kuang Yeh
Publikováno v:
Life Sciences. 278:119574
Aims Dipeptidyl peptidase 4 (DPP-4) is a valid molecular drug target from which its inhibitors have been developed as medicines for treating diabetes. The present study evaluated a new synthetic DPP-4-specific inhibitor of small molecule DBPR108 for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8184d757fd23f1031063a1719cbc4add
https://doi.org/10.1016/j.lfs.2021.119574
https://doi.org/10.1016/j.lfs.2021.119574
Autor:
Kun-Hung Lee, Wan-Ching Yen, Wen-Hsing Lin, Pei-Chen Wang, You-Liang Lai, Yu-Chieh Su, Chun-Yu Chang, Cai-Syuan Wu, Yu-Chen Huang, Chen-Ming Yang, Ling-Hui Chou, Teng-Kuang Yeh, Chiung-Tong Chen, Chuan Shih, Hsing-Pang Hsieh
Publikováno v:
Journal of Medicinal Chemistry; 10/14/2021, Vol. 64 Issue 19, p14477-14497, 21p
Publikováno v:
Journal of Functional Foods, Vol 27, Iss, Pp 150-159 (2016)
The objectives of this study were to compare the anti-inflammatory effect of ethyl extract from micronized and nonmicronized luffa peels in BALB/c mice, and to analyse the functional components in both extracts. Results showed that the concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ee1aba2c475ed556cd28891ace0ef6
http://www.sciencedirect.com/science/article/pii/S1756464616302754
http://www.sciencedirect.com/science/article/pii/S1756464616302754
Autor:
Kuei Jung Yen, Tsu Hsu, Ling Hui Chou, Yu Ling Huang, Yu-Sheng Chao, H. Eugene Liu, Cheng Tai Lu, Teng Kuang Yeh, Weir-Torn Jiaang, Jen Shin Song, Chun Hwa Chen, Po Chu Kuo, Ching Ping Chen, Shih Chieh Yen, Chiung-Tong Chen, Wen-Hsing Lin, Chen Lung Huang, John T.A. Hsu
Publikováno v:
European Journal of Medicinal Chemistry. 100:151-161
Numerous FLT3 inhibitors have been explored as a viable therapy for the treatment of acute myeloid leukemia (AML). However, clinical data have been underwhelming due to incomplete inhibition of FLT3 or the emergence of resistant mutations treated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b23817984e4202f9b481b6ab6ca61f
https://doi.org/10.1016/j.ejmech.2015.05.008
https://doi.org/10.1016/j.ejmech.2015.05.008
Autor:
Yung-Ning Yang, Wen-Hsing Lin, Ching-Ping Chen, Tsu Hsu, John T.A. Hsu, Weir-Torn Jiaang, Yu-Sheng Chao, Ching-Fang Yeh, Ling-Hui Chou, Chun-Hwa Chen, Teng-Kuang Yeh, Jen-Shin Song, Chiung-Tong Chen, Shu-Yi Hsieh, Cheng-Tai Lu, Ching-Hui Chiu, Shih-Chieh Yen, Ya-Ju Tseng, Kuei-Jung Yen
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2856-2867
Preclinical investigations and early clinical trials suggest that FLT3 inhibitors are a viable therapy for acute myeloid leukemia. However, early clinical data have been underwhelming due to incomplete inhibition of FLT3. We have developed 3-phenyl-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40789ec034aee7931573505d93f593c
https://doi.org/10.1016/j.bmc.2013.03.083
https://doi.org/10.1016/j.bmc.2013.03.083