Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ling F. Ye"'
Autor:
Pavan S. Upadhyayula, Dominique M. Higgins, Angeliki Mela, Matei Banu, Athanassios Dovas, Fereshteh Zandkarimi, Purvi Patel, Aayushi Mahajan, Nelson Humala, Trang T. T. Nguyen, Kunal R. Chaudhary, Lillian Liao, Michael Argenziano, Tejaswi Sudhakar, Colin P. Sperring, Benjamin L. Shapiro, Eman R. Ahmed, Connor Kinslow, Ling F. Ye, Markus D. Siegelin, Simon Cheng, Rajesh Soni, Jeffrey N. Bruce, Brent R. Stockwell, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Diet intervention is emerging as an option to improve cancer therapy. Here, the authors show that a diet with restrictive cysteine and methionine synergizes with a ferroptosis inducer to increase cell death and survival in glioma preclinical models.
Externí odkaz:
https://doaj.org/article/d887ba793f1142b985b1d97d66d45514
Autor:
Matei A. Banu, Athanassios Dovas, Michael G. Argenziano, Wenting Zhao, Henar Cuervo Grajal, Dominique M.O. Higgins, Colin P. Sperring, Brianna Pereira, Ling F. Ye, Aayushi Mahajan, Nelson Humala, Julia L. Furnari, Pavan S. Upadhyayula, Fereshteh Zandkarimi, Trang T. T. Nguyen, Peter B. Wu, Li Hai, Charles Karan, Aida Razavilar, Markus D. Siegelin, Jan Kitajewski, Jeffrey N. Bruce, Brent R. Stockwell, Peter A. Sims, Peter D. Canoll
Publikováno v:
bioRxiv
SUMMARYGlioma cells hijack developmental transcriptional programs to control cell state. During neural development, lineage trajectories rely on specialized metabolic pathways. However, the link between tumor cell state and metabolic programs is poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d307a66d6e7e7bb3360567afe6f972d
https://doi.org/10.1101/2023.02.22.529581
https://doi.org/10.1101/2023.02.22.529581
Autor:
Kimberly Malesky, Donald C. Lo, Guizhi Yang, Alice Loo, Hui Gao, Joshua M. Korn, Raymond Pagliarini, Brent R. Stockwell, Fallon Lin, Tom Mikkelsen, Eduard Reznik, Ana C. deCarvalho, Ling F. Ye
Publikováno v:
Oncotarget
There is a compelling need for new therapeutic strategies for glioblastoma multiforme (GBM). Preclinical target and therapeutic discovery for GBMs is primarily conducted using cell lines grown in serum-containing media, such as U-87 MG, which do not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e622bca7b5e1967914a420da39d39c8e
https://doi.org/10.18632/oncotarget.27457
https://doi.org/10.18632/oncotarget.27457
Autor:
Bryan Gibb, Ling F Ye, Stephanie C Gergoudis, YoungHo Kwon, Hengyao Niu, Patrick Sung, Eric C Greene
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87922 (2014)
Replication protein A (RPA) is a ubiquitous eukaryotic single-stranded DNA (ssDNA) binding protein necessary for all aspects of DNA metabolism involving an ssDNA intermediate, including DNA replication, repair, recombination, DNA damage response and
Externí odkaz:
https://doaj.org/article/8ad7a22fc0174f91a97b79220695b64a
Autor:
Eun Y. Lee, Kunal R. Chaudhary, Connor J. Kinslow, Ling F. Ye, Ramon C. Sun, Pavan S. Upadhyayula, Simon K. Cheng
Publikováno v:
Cancer Research. 81:1992-1992
Purpose/Objective(s): Lung cancer is the leading cause of cancer deaths in the United States and worldwide. There has been little improvement in survival over the past several decades and surgery is generally considered to be the only curative treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4dd364fb5756fcbefce629667f3ac98
https://doi.org/10.1158/1538-7445.am2021-1992
https://doi.org/10.1158/1538-7445.am2021-1992
Autor:
Peter Canoll, Pavan S. Upadhyayula, Connor J. Kinslow, Tom K. Hei, Hui Tan, Tony J. C. Wang, Brent R. Stockwell, Fereshteh Zandkarimi, Ling F. Ye, Athanassios Dovas, Yan Zhang, Simon K. Cheng, Andrew D. Harken, Jeffrey N. Bruce, Dominique M. Higgins, Kunal R. Chaudhary, Manuela Buonanno
Publikováno v:
ACS Chem Biol
Although radiation is widely used to treat cancers, resistance mechanisms often develop and involve activation of DNA repair and inhibition of apoptosis. Therefore, compounds that sensitize cancer cells to radiation via alternative cell death pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89218e1df5fd262449b8b8764f6b11a3
https://doi.org/10.2139/ssrn.3474050
https://doi.org/10.2139/ssrn.3474050
Autor:
Ling F. Ye, Brent R. Stockwell
Publikováno v:
Cell. 171(3)
Ferroptosis is a form of programmed cell death pathogenic to several acute and chronic diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsaturated fatty ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520fe1748d456f75cc3e0f07e71d8455
https://pubmed.ncbi.nlm.nih.gov/29053969
https://pubmed.ncbi.nlm.nih.gov/29053969
Publikováno v:
Nature Structural & Molecular Biology. 21:893-900
Homologous recombination is a conserved pathway for repairing double-stranded breaks, which are processed to yield single-stranded DNA overhangs that serve as platforms for presynaptic-complex assembly. Here we use single-molecule imaging to reveal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::324566f86ac998c177bb864fc6a6a681
https://doi.org/10.1038/nsmb.2886
https://doi.org/10.1038/nsmb.2886
DNA curtains: novel tools for imaging protein-nucleic acid interactions at the single-molecule level
Publikováno v:
Methods in cell biology. 123
Interactions between proteins and nucleic acids are at the molecular foundations of most key biological processes, including DNA replication, genome maintenance, the regulation of gene expression, and chromosome segregation. A complete understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a386b06bac554192b1af01f9ad2a574
https://pubmed.ncbi.nlm.nih.gov/24974030
https://pubmed.ncbi.nlm.nih.gov/24974030
Interactions between proteins and nucleic acids are at the molecular foundations of most key biological processes, including DNA replication, genome maintenance, the regulation of gene expression, and chromosome segregation. A complete understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::263e299c45d771880de278cc33f2405d
https://doi.org/10.1016/b978-0-12-420138-5.00012-4
https://doi.org/10.1016/b978-0-12-420138-5.00012-4