Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ling E Cheung"'
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005252 (2015)
Intrinsic immunity describes the set of recently discovered but poorly understood cellular mechanisms that specifically target viral pathogens. Their discovery derives in large part from intensive studies of HIV and SIV that revealed restriction fact
Externí odkaz:
https://doaj.org/article/a15fa3887a844a2481c0b40f3f256121
Autor:
Natsuko Terasaki, John L Goodier, Ling E Cheung, Yue J Wang, Masaki Kajikawa, Haig H Kazazian, Norihiro Okada
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74629 (2013)
The Long interspersed element 1 (LINE1 or L1) retrotransposon constitutes 17% of the human genome. There are currently 80-100 human L1 elements that are thought to be active in any diploid human genome. These elements can mobilize into new locations
Externí odkaz:
https://doaj.org/article/9e9265333f37481698de29ddfb47da1f
Publikováno v:
PLoS Genetics, Vol 8, Iss 10, p e1002941 (2012)
MOV10 protein, a putative RNA helicase and component of the RNA-induced silencing complex (RISC), inhibits retrovirus replication. We show that MOV10 also severely restricts human LINE1 (L1), Alu, and SVA retrotransposons. MOV10 associates with the L
Externí odkaz:
https://doaj.org/article/5b990803b7364b64ad99fa68b236c8ee
Publikováno v:
Human Molecular Genetics. 20:3386-3400
Human retrotransposons generate structural variation and genomic diversity through ongoing retrotransposition and non-allelic homologous recombination. Cell culture retrotransposition assays have provided great insight into the genomic impact of retr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da300626fdad3fa01200e28da000eacf
https://doi.org/10.1093/hmg/ddr245
https://doi.org/10.1093/hmg/ddr245
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005252 (2015)
PLoS Genetics
PLoS Genetics
Intrinsic immunity describes the set of recently discovered but poorly understood cellular mechanisms that specifically target viral pathogens. Their discovery derives in large part from intensive studies of HIV and SIV that revealed restriction fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84cd813fcef30e6c8f77cff53624097
http://europepmc.org/articles/PMC4441479?pdf=render
http://europepmc.org/articles/PMC4441479?pdf=render
Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition
Publikováno v:
Nucleic Acids Research
LINE1s occupy 17% of the human genome and are its only active autonomous mobile DNA. L1s are also responsible for genomic insertion of processed pseudogenes and >1 million non-autonomous retrotransposons (Alus and SVAs). These elements have significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de9e881a21a3f26f868a55b3a2ef25e
https://pubmed.ncbi.nlm.nih.gov/23749060
https://pubmed.ncbi.nlm.nih.gov/23749060
Publikováno v:
Molecular and cellular biology. 32(22)
RNA-based duplication mediated by reverse transcriptase (RT), a process termed retrotransposition, is ongoing in humans and is a source of significant inter- and perhaps intraindividual genomic variation. The long interspersed element 1 (LINE-1 or L1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00043b7ee14ee3a4c0cbdf076e1d73bd
https://pubmed.ncbi.nlm.nih.gov/23007156
https://pubmed.ncbi.nlm.nih.gov/23007156
Autor:
Masaki Kajikawa, Natsuko Terasaki, Norihiro Okada, Haig H. Kazazian, John L. Goodier, Yue J. Wang, Ling E. Cheung
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74629 (2013)
PLoS ONE
PLoS ONE
The Long interspersed element 1 (LINE1 or L1) retrotransposon constitutes 17% of the human genome. There are currently 80–100 human L1 elements that are thought to be active in any diploid human genome. These elements can mobilize into new location
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43f0af2c70e747b192546e33bbdc09f
https://doi.org/10.1371/journal.pone.0074629
https://doi.org/10.1371/journal.pone.0074629
Autor:
Sean L. Evans, Juan Du, Peng Li, Wenyan Zhang, Guanjun Wang, Ling E. Cheung, Haig H. Kazazian, Xiao Fang Yu, Xue Han, John L. Goodier, Linzhang Li, Wei Wei, Xiaohong Zhou, Ke Zhao
Publikováno v:
Cell reports
Cell Reports, Vol 4, Iss 6, Pp 1108-1115 (2013)
Cell Reports, Vol 4, Iss 6, Pp 1108-1115 (2013)
SUMMARY Long interspersed elements 1 (LINE-1) occupy at least 17% of the human genome and are its only active autonomous retrotransposons. However, the host factors that regulate LINE-1 retrotransposition are not fully understood. Here, we demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243882391204a9d1bdabb83fac472069
Autor:
Ke Zhao, Juan Du, Xue Han, John L. Goodier, Peng Li, Xiaohong Zhou, Wei Wei, Sean L. Evans, Linzhang Li, Wenyan Zhang, Ling E. Cheung, Guanjun Wang, Haig H. Kazazian, Jr., Xiao-Fang Yu
Publikováno v:
Cell Reports, Vol 4, Iss 6, Pp 1108-1115 (2013)
Long interspersed elements 1 (LINE-1) occupy at least 17% of the human genome and are its only active autonomous retrotransposons. However, the host factors that regulate LINE-1 retrotransposition are not fully understood. Here, we demonstrate that t
Externí odkaz:
https://doaj.org/article/2adc3efbdbab489fa324e398504c6bb4