IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.

Autor: Adami E; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School., Viswanathan S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School., Widjaja AA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School., Ng B; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore., Chothani S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School., Zhihao N; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore., Tan J; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore., Lio PM; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore., George BL; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School., Altunoglu U; Department of Medical Genetics, Koç University, School of Medicine, Istanbul, Turkey., Ghosh K; Genome Institute of Singapore, Human Genetics and Therapeutics Laboratory., Paleja BS; Institute of Molecular and Cellular Biology, A*STAR., Schafer S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore., Reversade B; Department of Medical Genetics, Koç University, School of Medicine, Istanbul, Turkey.; Genome Institute of Singapore, Human Genetics and Therapeutics Laboratory.; Institute of Molecular and Cellular Biology, A*STAR.; Department of Paediatrics, National University of Singapore., Albani S; Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre., Ling ALH; Department of Rheumatology and Immunology, Singapore General Hospital.; Duke-National University of Singapore Medical School, Singapore., O'Reilly S; Department of Biosciences, Durham University, Durham., Cook SA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London, UK.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2021 Dec 01; Vol. 60 (12), pp. 5820-5826.